Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage

Kaneko, Taizo; Horiuchi, Keisuke; Chijimatsu, Ryota; Mori, Daisuke; Nagata, Kisaburo; Omata, Yasunori; Yano, Fumiko; Inui, Hiroshi; Moro, Toru; Tanaka, Sakae; Saito, Taku

doi:10.1007/s00774-021-01278-3

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…In response to the inflammatory stimuli, activated ADAM17 prompts multiple receptor-mediated signal transduction by cleaving ectodomains of membrane proteins, including inflammatory cytokines, growth factors, receptors, and adhesion factors (7). The expression of ADAM17 in mouse articular cartilage is positively correlated with the development of arthritis, and its deletion attenuates articular cartilage degeneration (8). Moreover, ADAM17 is associated with glomerular inflammation and fibrosis (9).…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory role of metalloproteinase ADAM17 in tumor development

et al. 2022

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ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of transmembrane proteases involved in the shedding of some cell membrane proteins and regulating various signaling pathways. More than 90 substrates are regulated by ADAM17, some of which are closely relevant to tumor formation and development. Besides, ADAM17 is also responsible for immune regulation and its substrate-mediated signal transduction. Recently, ADAM17 has been considered as a major target for the treatment of tumors and yet its immunomodulatory roles and mechanisms remain unclear. In this paper, we summarized the recent understanding of structure and several regulatory roles of ADAM17. Importantly, we highlighted the immunomodulatory roles of ADAM17 in tumor development, as well as small molecule inhibitors and monoclonal antibodies targeting ADAM17.

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Section: Introductionmentioning

confidence: 99%

Immunomodulatory role of metalloproteinase ADAM17 in tumor development

et al. 2022

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“…Transcription elongation factor A1 (TCEA1) can promote the transcription extension of genes and also regulate fatty acid synthesis or ß-The ex-pression of oxidation-related genes significantly, promoted the lipid accumulation of AML12 hepatocytes (Shang et al, 2022). Moreover, there are many growth factors, such as disintegrin metalloproteinase 17 (ADAM7), high mobility group protein 1 (HMG1), which act together with other growth factors to promote the proliferation and growth of individual cells (Kaneko et al, 2022). Growth hormone release inhibitory factor (GRIF) is a peptide hormone that regulates the endocrine system (Heo et al, 2022), participates in the regulation of growth hormone and insulin, promotes the growth of animals and participates in the metabolic regulation of the body (Svendsen and Holst, 2021).…”

Section: Introductionmentioning

confidence: 99%

Body Size Effect in Eothenomys miletus of Different Regions from Hengduan Mountain Regions: Roles of Growth Factor Contents

Jia,

Liao,

Zhang

et al. 2024

IJAR

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Background: Growth factors are active substances secreted by a variety of cells, acting as messengers to regulate cell migration, proliferation or differentiation, which had important regulatory roles in the growth of individual cells, tissues or organs. Growth factors can regulate the proliferation and differentiation ability of cells, which keep the internal environment stable and affect the body size. Methods: In order to investigate the influence of the changes of growth factors contents on body size in Eothenomys miletus from Hengduan mountain regions, E. miletus in Dali (DL), Jianchuan (JC), Lijiang (LJ), Xianggelila (XGLL) and Deqin (DQ) were collected and their 7 morphological indicators and 9 growth factors, including insulin-like growth factor1 (IGF1), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), growth hormone release inhibitory factor (GRIF), platelet-derived growth factor (PDGF), transcription elongation factor1 (TCEA1), a disintegrin and metalloprotease17 (ADAM7), branched-chain amino acid transaminase1 (BCAT1), high mobility group protein1 (HMG1) were measured. Result: The results showed that body size of E. miletus among five regions had significant differentiated, body mass, body length, forelimb length, hind limb length, tail length, IGF, bFGF, EGF, PDGF, TCEA1 contents in DL, JC and LJ were greater than those of in XGLL and DQ and the contents of GRIF, ADAM7, BCAT1 and HMG1 were also different, decreasing with the increasing of regional latitude. Moreover, the increases in the contents of growth factors lead to the increase of body size in E. miletus, which does not support Bergman's law. Regional differences in body size of E. miletus in different regions may be related to the changes in body mass, morphological indicators and the content of growth factors. Moreover, growth factors may affect the body size of E. miletus by affecting the proliferation of bone, epidermis, muscle and differentiation of cells.

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