Regulation of Paraquat for wheat crop contamination

Gupta, Sandhya; Garg, Navneet; Shekhawat, Kapila

doi:10.1007/s11356-022-20816-8

Cited by 8 publications

(2 citation statements)

References 55 publications

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“…China is still responsible for manufacturing and exporting PQ to over 70 countries worldwide 4 . A key problem is that the application of PQ will inevitably remain as residue in crops and environmental media, and human beings are exposed to the residual PQ via intake of the contaminated food or water 5 . Hence, scientists are largely focused on removing or reducing PQ residues in water and soil 6 …”

Section: Introductionmentioning

confidence: 99%

“…4 A key problem is that the application of PQ will inevitably remain as residue in crops and environmental media, and human beings are exposed to the residual PQ via intake of the contaminated food or water. 5 Hence, scientists are largely focused on removing or reducing PQ residues in water and soil. 6 In human health risk assessment, however, low doses of PQ may not be paid attention to, but long-term and low-dose exposure to exogenous chemicals should be more focused, which will inevitably impact the body and harm population health.…”

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confidence: 99%

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A potential mechanism clue to the periodic storm from microglia activation and progressive neuron damage induced by paraquat exposure

Shi,

Zhang,

Bai

et al. 2024

Environmental Toxicology

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Paraquat (PQ), is characterized by neurotoxicity, which increases the potential risk of Parkinson's disease (PD) exposure in the long‐term and low doses. Triggering microglia activation and neuroinflammation is deemed an early event resulting in PD. However, the underlying pathogenesis of PD by PQ is not clear yet. In this article, C57BL/6J mice treated with PQ could successfully act out Parkinson‐like. In addition, we observed the fluorescence intensity enhancement of Iba‐1 activated microglia with released pro‐inflammatory, all ahead of both the damage of dopaminergic neurons in the substantia nigra and corpus striatum of the brain. Surprisingly, the injection of minocycline before PQ for many hours not only can effectively improve the neurobehavioral symptoms of mice but inhibit the activation of microglia and the release of pro‐inflammatory substances, even controlling the gradual damage and loss of neurons. A further mechanism of minocycline hampered the expression levels of key signaling proteins PI3K, PDK1, p‐AKT, and CD11b (the receptor of microglia membrane recognition), while a large number of inflammatory factors. Our results suggested that the CD11b/PI3K/NOX2 pathway may be a clue that microglia‐mediated inflammatory responses and neuronal damage in a PQ‐induced abnormal behavior Parkinson‐like mouse.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%