Regulation of Production of Mucosal Antibody to Pneumococcal Protein Antigens by T-Cell-Derived Gamma Interferon and Interleukin-10 in Children

Interleukin-21 Augments the Efficacy of T-Cell Therapy by Eliciting Concurrent Cellular and Humoral Responses

“…The role of IL-10 in the antitumor response mediated by the transferred cells needs to be further explored. IL-10 is an important immunoregulatory cytokine that plays a critical role in initiating and maintaining antibody responses (39)(40)(41). The enhanced IL-10 production may be correlated with the increased humoral responses observed in this study.…”

Production of cytokines by mononuclear cells of hypertrophic adenoids in children with otitis media with effusion

“…IL-10 was shown to be capable to inhibit synthesis of pro-inflammatory cytokines like IFN-g, IL-2 and IL-3 [24,25]. T-cell derived IFN-g and IL-10 may be key regulators of the production of mucosal antibody to pneumococcal protein antigens in the nasopharynx and may play an important role in local protection against pneumococcal infection in children [26].…”

Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in Mice

“…Nevertheless, inflammatory cell influx into the lung and mucosal responses must be regulated to avoid exacerbated tissue injury. This is evidenced in recent studies of the role of ␥␦ T cells and/or anti-inflammatory cytokines, such as interleukin-10 (IL-10), in pneumococcal infection (26,42,55).…”