Regulation of Prolactin Receptors in Target Cells

Shiu, Robert P. C.; Friesen, Henry G.

doi:10.1007/978-94-009-5822-7_4

Cited by 4 publications

(2 citation statements)

References 54 publications

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“…Most calciumbinding proteins are expressed in a number of tissues. Calcyclin mRNA is distributed over lung, kidney and uterus [16]. The tissue distribution of calcyphosine ineludes thyroid, salivary gland, kidney, lung and brain [17].…”

Section: Discussionmentioning

confidence: 99%

Calcium administration stimulates the expression of calcium‐binding protein regucalcin mRNA in rat liver

1992

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The distribution and expression of mRNA ene.oding the Ca2"-binding protein regucalcin in rats were investigated by Northern blot analys~. Li~ver regucalein eDNA (0.6 kb) was used as a prob~. The analyses of total RNAs extracted from various tissues of rat indicated that r~gu~tlcin mRlqA was mainly prc~ent in liver but only slightly in kidney with a size of 1.8 kb. The expression level decr~d with increasing age (3, 10 and 25 wc~ks). A single intra~riton~i administration of calcium chloride (15 mg Ca/100 g body weight) induced a remarkable increase in regucalcin mRNA in liver; the level was about 200% of control at 30 rain after the administration. Sub~quently, the expression level began to decrease with time and was about 40% of control level at 120 rain after the administration. The il~emas~ in regueaicin mRNA levels at 30 rain after calcium administration was dos@dependent. These observations show that the expression of regueal¢in mRNA is specific in liver of various tissues, and that it is regulated by Ca :" administration. Regu~l¢in may have a role as regulatory protein for calcium homeostasis in liver cells.

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Section: Discussionmentioning

confidence: 99%

Calcium administration stimulates the expression of calcium‐binding protein regucalcin mRNA in rat liver

1992

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“…For example, insulin induces a specific, reversible, and dose-dependent increase in high-affinity insulin receptors on rat chondrosarcoma cells (19). Manipulations that increase prolactin levels in hypophysectomized rats increased prolactin receptors on rat hepatocytes (20). Finally, receptors for the Fc region of IgE (21) and IgA (22) appear to be induced by incubation with their specific ligands.…”

Section: Il-2 Augments Il-2 Receptor Mrna Expression and Il-2mentioning

confidence: 99%

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.

Depper¹,

Leonard²,

Drogula³

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

238

124

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We demonstrate that purified interleukin 2 (IL-2) can directly upregulate IL-2 receptor expression on phytohemagglutinin-activated T lymphocytes maintained in culture until IL-2 receptor expression had markedly declined. The IL-2-induced increase in IL-2 receptor number is maximal within 12 hr, requires new RNA and protein synthesis, and is mediated by an interaction of ligand with the high-affinity receptors for IL-2. IL-2 stimulation results in increased accumulation of IL-2 receptor mRNA within 4 hr, while an increase in IL-2 receptor gene transcription is detected within 30 min in isolated nuclei. In addition, IL-2 incubation results in increased amounts of c-myc and transferrin receptor mRNA, but it does not augment levels of mRNA encoding the fi chain of the T-cell receptor for antigen. These results demonstrate that IL-2 can directly upregulate transcription and expression of its own receptor and, therefore, indicate that IL-2 may regulate IL-2-dependent immune responses, in part, by influencing the expression of IL-2 receptors.

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Effect of Pregnancy and Exogenous Ovarian Steroids on Endometrial Prolactin Receptor Ontogeny and Uterine Secretory Response in Pigs1

Young

Kraeling²,

Bazer

1990

Biology of Reproduction

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During gestation, pigs have constant circulating levels of prolactin (PRL), and lack decidual PRL and placental lactogens. Effects of PRL on uterine physiology in pigs may be due to changes in endometrial PRL receptors. In this study, effects of the conceptus and cyclic hormonal environment on endometrial PRL receptors were investigated. Endometrial PRL receptor numbers were similar between Days 8 and 15 for cyclic gilts. In contrast, endometrial PRL receptor numbers for pregnant gilts were similar between Days 8 and 11, then increased (p less than 0.05) on Day 12 and remained elevated between Days 14 and 30. This day-by-status interaction approached significance (p less than 0.06) and overall receptor numbers were higher (p less than 0.01) for pregnant than for cyclic gilts. Pig conceptuses secrete estrogen between Days 11 and 12; therefore, regulation of endometrial PRL receptors by acute administration of estradiol was investigated. Uterine flushings and endometrium were collected from one uterine horn of cyclic gilts on Day 11; then, at 1, 6, 12, and 24 h following a single injection of estradiol valerate (EV; 5 mg, into adipose tissue), uterine flushings and endometrium were collected from the second uterine horn. Endometrial PRL receptor numbers were higher (p less than 0.05) at both 1 h and 6 h after treatment with EV and then decreased (p less than 0.02) by 12 h to below pretreatment values. In uterine flushings, total recoverable protein (p less than 0.05), uteroferrin (p less than 0.01), leucine aminopeptidase (p less than 0.05), calcium (p less than 0.03), sodium (p less than 0.01), and potassium (p less than 0.05) increased between 12 and 24 h following EV treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

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Regulation of Prolactin Receptors in Target Cells

Cited by 4 publications

References 54 publications

Calcium administration stimulates the expression of calcium‐binding protein regucalcin mRNA in rat liver

Calcium administration stimulates the expression of calcium‐binding protein regucalcin mRNA in rat liver

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.

Effect of Pregnancy and Exogenous Ovarian Steroids on Endometrial Prolactin Receptor Ontogeny and Uterine Secretory Response in Pigs1

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