Regulation of renal function and structure by the signaling Na/K-ATPase

Xie, Junyi; Li, Xin; Xie, Zijian

doi:10.1002/iub.1229

Cited by 47 publications

(43 citation statements)

References 130 publications

(197 reference statements)

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“…It integrates an ␣-subunit, responsible for ion movement and various binding sites, and a ␤-subunit, required for the correct enzyme assembly and membrane targeting. Four ␣-isoforms and two ␤-isoforms have been identified: ␣ 1 is ubiquitously expressed, ␣ 2 and ␣ 3 are found in skeletal muscle, neurons, and cardiomyocytes, and ␣ 4 is expressed in testis (149). Besides ion transport function, NKA is a receptor for endogenous cardiotonic steroids (such as ouabain) that trigger several intracellular signal pathways while blocking the ionic transport (149).…”

Section: Healthy Intestinal Tract Epitheliummentioning

confidence: 99%

“…Four ␣-isoforms and two ␤-isoforms have been identified: ␣ 1 is ubiquitously expressed, ␣ 2 and ␣ 3 are found in skeletal muscle, neurons, and cardiomyocytes, and ␣ 4 is expressed in testis (149). Besides ion transport function, NKA is a receptor for endogenous cardiotonic steroids (such as ouabain) that trigger several intracellular signal pathways while blocking the ionic transport (149). NKA maintains chemical and electrical gradient between intra-and extracellular spaces, allowing the movement of several ions, most importantly Na Ϫ .…”

Section: Healthy Intestinal Tract Epitheliummentioning

confidence: 99%

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Role of epithelial ion transports in inflammatory bowel disease

Magalhães

Cabral

Soares‐da‐Silva

et al. 2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with a complex pathogenesis. Diarrhea is a highly prevalent and often debilitating symptom of IBD patients that results, at least in part, from an intestinal hydroelectrolytic imbalance. Evidence suggests that reduced electrolyte absorption is more relevant than increased secretion to this disequilibrium. This systematic review analyses and integrates the current evidence on the roles of epithelial Na+-K+-ATPase (NKA), Na+/H+ exchangers (NHEs), epithelial Na+ channels (ENaC), and K+ channels (KC) in IBD-associated diarrhea. NKA is the key driving force of the transepithelial ionic transport and its activity is decreased in IBD. In addition, the downregulation of apical NHE and ENaC and the upregulation of apical large-conductance KC all contribute to the IBD-associated diarrhea by lowering sodium absorption and/or increasing potassium secretion.

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Section: Healthy Intestinal Tract Epitheliummentioning

confidence: 99%

Section: Healthy Intestinal Tract Epitheliummentioning

confidence: 99%

Role of epithelial ion transports in inflammatory bowel disease

Magalhães

Cabral

Soares‐da‐Silva

et al. 2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Studies have found that MBG activated pre-fibrotic signal, which could activate various signaling pathways and EGFR signals by inhibiting NKA, leaded to degeneration of the left ventricular muscle fli-1 and inducing collagen -1 synthesis (Elkareh et al, 2009;Liu et al, 2012;Xie et al, 2013). Study found myocardial fibrosis and siginificant elevation of MBG level in rats with a minipump for infusing MBG and rats had uremia myocarditis (Elkareh et al, 2007).…”

Section: Marinobufagenin and Fibrosismentioning

confidence: 99%

“…Although in the short term, the effect of MBG might balance the high salt load and slow the elevation of blood pressure (Mou et al, 2014), the vasoconstrictive effected by inhibiting NKA may be the long-term response of MBG. In addition, Dietary sodium restriction did not reduce level of plasma MBG (Jablonski et al, 2013).Studies have found that MBG activated pre-fibrotic signal, which could activate various signaling pathways and EGFR signals by inhibiting NKA, leaded to degeneration of the left ventricular muscle fli-1 and inducing collagen -1 synthesis (Elkareh et al, 2009;Liu et al, 2012;Xie et al, 2013). Study found myocardial fibrosis and siginificant elevation of MBG level in rats with a minipump for infusing MBG and rats had uremia myocarditis (Elkareh et al, 2007).…”

mentioning

confidence: 98%

Research Progress of Marinobufagenin and Salt-Sensitive Hypertension

Yuan¹,

Xiaoxiao²,

Xinghui³

et al. 2018

gab

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Salt-sensitive hypertension is a special type of hypertension. Because of its special pathogenesis and clinical features, it has attracted more and more attention in recent years. Marinobufagenin is a kind of endogenous digitals-like substance, which is the unitary ligand of Na + /K + ATPase widely distributed in human and animal. Marinobufagenin mediates water sodium retention, increases blood pressure, and interferes myocardial and vascular fibrosis and other pathologic mechanisms by blocking Na + /K + ATPase and various signaling pathways, which playes an importent role in the occurrence and development of salt-sensitive hypertension. This article hlights recent advances of the relation between marinobufagenin and salt-sensitive hypertension.Keywords Marinobufagenin; Salt-sensitive hypertension; Na + /K + -ATPase; Endogenous digitals-like substance Salt-Sensitive HypertensionSalt is one of the crucial risk factors of essential hypertension. A mass of clinical observations, animal experiments and ecological studies have documented the intimate association between salt and blood pressure.The different blood pressure response of individuals to salt load showed a discrete distribution, which confirmed the presence of salt sensitivity. Salt sensitivity is the genetic basis of salt connects hypertension, is an intermediate genetic phenotype of essential hypertension. The salt sensitivity of blood pressure, defined as an exaggerated pressor response to dietary salt intake, jointly determined by genetic factors, age, body mass index (BMI), concomitant diseases, ethnic factor, increases the risk of hypertension (Carey et al., 2012; Kotchen et al., 2013;Felder et al., 2013;Frame et al., 2017), and the associated hypertension defined as salt sensitivity hypertension (salt-sensitive hypertension, SSH). Some people have significant blood pressure increase after high salt intake is called salt-sensitive subjects, while the other group have no obvious increase in blood pressure is called non-salt-sensitive subjects. SSH is an important characteristic of hypertension in China, affects approximately 50% of hypertensive patients, 25% of normotensive adults (Kotchen et al., 2013;Felder et al., 2013 ) and about 40% of the teenages have salt sensitivity in positive family history of hypertension (Mou et al, 2012). It is a complex disease related to regional, ethnic, demographic and social factors, as well as an independent risk factor for cardiovascular disease. Endogenous Digitals-like Substance and MarinobufageninEndogenous digitals-like substance (ELDS)， which has similar characters with exogenous digitalis in structure, physico and chemical properties and biological functionis, is classified into two groups. Endogenous cardenolids have similar structure with digitalatis from plant, including endogenous ouabain (EO) and endogenous digoxin. Another group is endogenous bufadienolides, including endogenous marinobufagenin (MBG), telocinobufagin and bufalin， which have similar structure with bufotoxin that originally disc...

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“…Cytosolic [Na + ] overload is accentuated by intracellular acidosis, which induces Na + entry through the NHE. The ischemia associated acidosis contributes to increase cytosolic Ca 2+ induced by the NHE, which is strongly coupled to NCX, so that in long term the cytosolic H + is exchanged with extracellular Ca 2+ [23][24]. Inhibitors of the Na + /H + exchanger were found to be protective if used before ischemia, while their effectiveness was reduced when given during the reperfusion phase [25][26].…”

Section: Effect Of Ischemia/reperfusion In Cardiomyocytesmentioning

confidence: 99%

Investigation of the cardioprotective effect of selective NCX inhibition in cellular models

Kormos¹

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Regulation of renal function and structure by the signaling Na/K-ATPase

Cited by 47 publications

References 130 publications

Role of epithelial ion transports in inflammatory bowel disease

Role of epithelial ion transports in inflammatory bowel disease

Research Progress of Marinobufagenin and Salt-Sensitive Hypertension

Investigation of the cardioprotective effect of selective NCX inhibition in cellular models

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