Regulation of Skeletal Muscle Peroxisome Proliferator-Activated Receptor .GAMMA. Expression by Exercise and Angiotensin-Converting Enzyme Inhibition in Fructose-Fed Hypertensive Rats

Kawamura, Takayuki; Yoshida, Kazunori; Sugawara, Akira; Nagasaka, Makoto; Mori, Nobuyoshi; Takeuchi, Kazuhisa; Kohzuki, Masahiro

doi:10.1291/hypres.27.61

Cited by 31 publications

(29 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The finding of no difference in muscle PPARα contrasts with the increase reported in bicycle-trained women by Horowitz et al [1], but is in agreement with Tunstall et al [30] and Schmitt et al [31] who found no effect of training on the PPARα messenger RNA content of human skeletal muscle. Likewise, the finding of no difference in muscle PPARγ contrasts with the increase reported in the soleus and extensor digitorum longus muscles of treadmill-trained fructose-fed hypertensive rats by the only relevant study [18], although we agree on no change in adipose tissue PPARγ. The different muscles examined and the different exercise mode may have contributed to the discrepancy between the 2 studies.…”

Section: Discussioncontrasting

confidence: 48%

See 1 more Smart Citation

Long-term exercise increases the DNA binding activity of peroxisome proliferator–activated receptor γ in rat adipose tissue

et al. 2007

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 48%

“…These have reported increases in the PPARα [1,17], PPARγ [18], and PPARδ contents [7,19] of skeletal muscle; increase in the PPARα content and DNA binding activity of PPARα in the heart [20]; and no difference in PPARγ of adipose tissue [18].…”

Section: Introductionmentioning

confidence: 99%

Long-term exercise increases the DNA binding activity of peroxisome proliferator–activated receptor γ in rat adipose tissue

et al. 2007

View full text Add to dashboard Cite

“…Oxidative stress also downregulates Klotho mRNA and protein expression levels in mouse kidney cells (33), and a free radical scavenger upregulates Klotho mRNA and protein expression levels (40). Moreover, previous studies have suggested that exercise training increases PPAR␥ (17) and decreases AT1R (6) and oxidative stress (2). Therefore, exercise training might also increase circulating Klotho through the increases in PPAR␥ and decreases in AT1R and oxidative stress in the kidney.…”

Section: Discussionmentioning

confidence: 99%

Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women

Matsubara

Miyaki

Akazawa

et al. 2014

American Journal of Physiology-Heart and Circulatory Physiology

104

105

View full text Add to dashboard Cite

The Klotho gene is a suppressor of the aging phenomena, and the secretion as well as the circulation of Klotho proteins decrease with aging. Although habitual exercise has antiaging effects (e.g., a decrease in arterial stiffness), the relationship between Klotho and habitual exercise remains unclear. In the present study, we investigated the effect of habitual exercise on Klotho, with a particular focus on arterial stiffness. First, we examined the correlation between plasma Klotho concentration and arterial stiffness (carotid artery compliance and ␤-stiffness index) or aerobic exercise capacity [oxygen uptake at ventilatory threshold (VT)] in 69 healthy, postmenopausal women (50 -76 years old) by conducting a cross-sectional study. Second, we tested the effects of aerobic exercise training on plasma Klotho concentrations and arterial stiffness. A total of 19 healthy, postmenopausal women (50 -76 years old) were divided into two groups: control group and exercise group. The exercise group completed 12 wk of moderate aerobic exercise training. In the crosssectional study, plasma Klotho concentrations positively correlated with carotid artery compliance and VT and negatively correlated with the ␤-stiffness index. In the interventional study, aerobic exercise training increased plasma Klotho concentrations and carotid artery compliance and decreased the ␤-stiffness index. Moreover, the changes in plasma Klotho concentration and arterial stiffness were found to be correlated. These results suggest a possible role for secreted Klotho in the exercise-induced modulation of arterial stiffness.Klotho; aerobic exercise; arterial stiffness AN INCREASE IN ARTERIAL STIFFNESS is an independent risk factor for cardiovascular morbidity and mortality (22, 51). Arterial stiffness is known to increase with aging (39). Moreover, menopause augments the age-related increase in arterial stiffness (56), and older women have higher arterial stiffness than do men (52). Furthermore, habitual aerobic exercise decreases arterial stiffness in middle-aged and elderly individuals and postmenopausal women (45,47). Several reports have suggested that the mechanisms by which aerobic exercise training decreases the arterial stiffness could be partly mediated by the enhancement of endothelial function, suppression of oxidative stress, and inflammation (24,27,46). However, the precise mechanism underlying the aerobic exercise-induced modulation of arterial stiffness remains unclear.

show abstract

“…Exercise also increases PPARγ in skeletal muscle [94] and muscle-specific deletion of PPARγ in mice showed insulin resistance [95]. Specific n-3 PUFA have been shown to activate PPARγ expression in adipocytes.…”

Section: Cb1mentioning

confidence: 99%

The endocannabinoid signaling system: a marriage of PUFA and musculoskeletal health

Watkins

Hutchins

et al. 2010

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

Regulation of Skeletal Muscle Peroxisome Proliferator-Activated Receptor .GAMMA. Expression by Exercise and Angiotensin-Converting Enzyme Inhibition in Fructose-Fed Hypertensive Rats

Cited by 31 publications

References 60 publications

Long-term exercise increases the DNA binding activity of peroxisome proliferator–activated receptor γ in rat adipose tissue

Long-term exercise increases the DNA binding activity of peroxisome proliferator–activated receptor γ in rat adipose tissue

Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women

The endocannabinoid signaling system: a marriage of PUFA and musculoskeletal health

Contact Info

Product

Resources

About