Regulation of steroidogenesis by atrial natriuretic peptide (ANP) in the rat testis: Differential involvement of GC-A and C receptors

Pereira, Virginia M.; Costa, Amilton Paulo Raposo; Rosa-E-Silva, A. A. M.; Vieira, Maria Aparecida Ribeiro; Reis, Adelina Martha dos

doi:10.1016/j.peptides.2008.08.005

Cited by 12 publications

(11 citation statements)

References 47 publications

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“…Hong et al (1992) demonstrated that testosterone promotes an increase in ANP expression. In addition, Pereira et al (2008) demonstrated that ANP stimulates testosterone synthesis, which could explain the increased testosterone levels observed in the present study.…”

Section: Discussionsupporting

confidence: 72%

Nandrolone decanoate induces cardiac and renal remodeling in female rats, without modification in physiological parameters: The role of ANP system

et al. 2015

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Section: Discussionsupporting

confidence: 72%

Nandrolone decanoate induces cardiac and renal remodeling in female rats, without modification in physiological parameters: The role of ANP system

et al. 2015

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“…In males, luteinizing hormon acts on Leydig cells in the testes to produce testosterone, whereas follicle-stimulating hormone acts on the Sertoli cells to maintain their nursemaid function in spermatogenesis. A previous report showed that all three peptides could stimulate testosterone production in vivo, with significant effects at concentrations o1310 28 20 Pereira et al 21 found that ANP stimulated testosterone production in rat testis perfused in vitro but decreased luteinizing hormone-induced testosterone production, which seemed to involve the C receptor. As a local paracrine or autocrine regulator, CNP may be produced by most of the major endocrine glands, including the hypothalamus and the anterior pituitary.…”

Section: Discussionmentioning

confidence: 89%

The role of C-type natriuretic peptide in rat testes during spermatogenesis

Huang¹,

Zhang²,

Zhao³

et al. 2010

Asian J Androl

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C-type natriuretic peptide (CNP) is a 22-amino acid peptide and act as a local paracrine or autocrine regulator. There is growing evidence that CNP is involved in male reproductive processes. To investigate the role of CNP during spermatogenesis, we measured the mRNA expression of CNP and its specific membrane-bound natriuretic peptide receptor-B (NPR-B) using real-time RT-PCR in the testes of normal rats on different postnatal days. After that spermatogenesis dysfunction model induced by ornidazole was established with the aim to study the correlation of CNP with spermatogenic dysfunction. Then, Sertoli cells from 18-to 22-day-old healthy male rats were cultured in the presence of different CNP concentrations (1310 26, 1310 27 and 1310 28 mol l 21), and the mRNA expression levels of androgen-binding protein, inhibin B and transferrin were examined at 0 min, 30 min, 1 h, 2 h, 4 h, 8 h, 12 h, 24 h and 48 h. During the postnatal development of rat testes, the highest mRNA expression levels of CNP and NPR-B were found at postnatal D 0 , and the levels then declined gradually, with a second CNP peak at postnatal D 35 . In the ornidazole-induced infertile rat testes, CNP gene expression was lower than in the uninduced rats (P,0.05), while NPR-B gene expression was greater (P,0.05). In cultured Sertoli cells, supplementation with CNP stimulated the gene expression of androgen-binding protein/inhibin B/transferrin, particularly at 12 h, and 1310 27 mol l 21 CNP had the highest upregulation effect. The gene expression levels of CNP/NPR-B in rat testes at different postnatal stages and in infertile rat testes indicated that CNP may participate in the physiology and/or pathology related to spermatogenesis. Moreover, CNP regulated endocrine function in Sertoli cells. Taken together, these results showed that CNP is closely tied to spermatogenesis.

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“…Real-time polymerase chain reaction (PCR) was carried out as described previously (26) in a Abi-Prism 7700 Sequence Detection System, with use of the fluorescent dye SYBR Green Master Mix (Applied Biosystems, Foster City, CA). The primers used for PCR amplification of Mas and ACE2 are listed in Table 1.…”

Section: Real-time Polymerase Chain Reactionmentioning

confidence: 99%

Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary

Reis

Bouissou

Pereira

et al. 2011

Fertility and Sterility

168

128

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Regulation of steroidogenesis by atrial natriuretic peptide (ANP) in the rat testis: Differential involvement of GC-A and C receptors

Cited by 12 publications

References 47 publications

Nandrolone decanoate induces cardiac and renal remodeling in female rats, without modification in physiological parameters: The role of ANP system

Nandrolone decanoate induces cardiac and renal remodeling in female rats, without modification in physiological parameters: The role of ANP system

The role of C-type natriuretic peptide in rat testes during spermatogenesis

Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary

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