2007
DOI: 10.1146/annurev.genet.41.110306.130315
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Regulation of Sterol Synthesis in Eukaryotes

Abstract: Cholesterol is an essential component of mammalian cell membranes and is required for proper membrane permeability, fluidity, organelle identity, and protein function. Cells maintain sterol homeostasis by multiple feedback controls that act through transcriptional and posttranscriptional mechanisms. The membrane-bound transcription factor sterol regulatory element binding protein (SREBP) is the principal regulator of both sterol synthesis and uptake. In mammalian cells, the ER membrane protein Insig has emerge… Show more

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Cited by 486 publications
(514 citation statements)
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“…Sterol biosynthesis in yeast is an essential process involving over 20 enzymatic steps (33)(34)(35). The second half of the sterol biosynthetic pathway is dedicated to the production of ergosterol, the major oxysterol of yeast, and begins with the condensation of two farnesyl pyrophosphate molecules to form squalene (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Sterol biosynthesis in yeast is an essential process involving over 20 enzymatic steps (33)(34)(35). The second half of the sterol biosynthetic pathway is dedicated to the production of ergosterol, the major oxysterol of yeast, and begins with the condensation of two farnesyl pyrophosphate molecules to form squalene (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…31 SREBPs are a family of master transcription factors that controls the expression of lipogenic enzymes. [40][41][42][43] Second, our microarray analysis revealed altered expression of genes whose products were involved in regulating lipid metabolism when CDK8 is overexpressed ( Fig. 3E and F).…”
Section: Overexpression Of Cdk8 Inhibits Growth Of Human Endometrial mentioning
confidence: 90%
“…Cholesterol homeostasis is achieved through an intricate network of sensing and effector mechanisms (1). Cells accumulate cholesterol through two distinct but linked pathways of lipoprotein cholesterol uptake and de novo cholesterol biosynthesis (2).…”
mentioning
confidence: 99%