Regulation of T cell proliferation by IL-7.

Grabstein, K H; Namen, Anthony E.; Shanebeck, Kurt; Voice, R F; Reed, S G; Widmer, Michael B.

doi:10.4049/jimmunol.144.8.3015

Cited by 94 publications

(2 citation statements)

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“…However, there have been conflicting results regarding the role of IL-7/IL-7R in Treg development. While IL-2 is known to play a crucial role in Treg homeostasis [ 42 ], it has been discovered that CD25-deficient Tregs rely on IL-7 for survival in the absence of IL-2 [ 43 ]. On the other hand, some studies have indicated that IL-7Rα alone is not enough to promote mature Treg development [ 44 ].…”

Section: Biological Functions Of Il-7mentioning

confidence: 99%

Advances in IL-7 Research on Tumour Therapy

Fu,

Zhang,

Zhang

et al. 2024

Pharmaceuticals

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Interleukin-7 (IL-7) is a versatile cytokine that plays a crucial role in regulating the immune system’s homeostasis. It is involved in the development, proliferation, and differentiation of B and T cells, as well as being essential for the differentiation and survival of naïve T cells and the production and maintenance of memory T cells. Given its potent biological functions, IL-7 is considered to have the potential to be widely used in the field of anti-tumour immunotherapy. Notably, IL-7 can improve the tumour microenvironment by promoting the development of Th17 cells, which can in turn promote the recruitment of effector T cells and NK cells. In addition, IL-7 can also down-regulate the expression of tumour growth factor-β and inhibit immunosuppression to promote anti-tumour efficacy, suggesting potential clinical applications for anti-tumour immunotherapy. This review aims to discuss the origin of IL-7 and its receptor IL-7R, its anti-tumour mechanism, and the recent advances in the application of IL-7 in tumour therapy.

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Section: Biological Functions Of Il-7mentioning

confidence: 99%

Advances in IL-7 Research on Tumour Therapy

Fu,

Zhang,

Zhang

et al. 2024

Pharmaceuticals

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“…Interleukin-7 (IL-7), a potent cytokine for lymphoid cells at the pre-B stage of development, was recently purified and cloned from bone marrow stromal cells. It induces proliferation but not differentiation of pre-B cells (29,38), and also has growth stimulatory effects on early and mature T-cells (6,15,37,47). A receptor for IL-7 was recently cloned and shown to be expressed on pre-B cells, progenitors to pre-B cells, and some myeloid and T cells, but not on mature B cells (14,40).…”

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confidence: 99%

Hyperexpression of Interleukin-7 Is Not Necessary or Sufficient for Transformation of a Pre-B Lymphoid Cell Line

Young

Gishizky

Witte

1991

Molecular and Cellular Biology

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Interleukin-7 (IL-7) is a potent stimulator of pre-B-lymphocyte proliferation. Pre-B cells transformed by a variety of oncogenes including those of the ABL protein tyrosine kinase family were screened for endogenous IL-7 mRNA expression by polymerase chain reaction and a sensitive bioassay for secreted IL-7. Some v-abl but none of the BCR/ABL, v-src, v-fms, v-myc, v-ras, or v-raf transformants analyzed contained elevated IL-7 transcripts. None of the cell lines secreted detectable bioactivity. We overexpressed IL-7 via a retroviral vector in an IL-7-dependent pre-B cell line to assess the potential for autocrine growth stimulation and malignant transformation. We achieved dramatic deregulation of IL-7 translational suppression by removing portions of the 5' flanking region. Levels of IL-7 expression much greater than those needed to establish factor-independent growth did not induce colony formation in agar by IL-7-expressing pre-B cell lines, and the majority of these lines were nontumorigenic in syngeneic mice. The same pre-B cell line transformed by v-abl displayed a highly malignant phenotype while containing dramatically lower IL-7 transcript levels. We conclude that endogenous IL-7 expression is not a necessary event in transformation of pre-B cells, nor is it sufficient to explain the malignant phenotype in v-abl-transformed cells. Up regulation of endogenous IL-7 expression in some transformed pre-B cells may be one of several synergistic events which can lead to malignant conversion.

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Human Lymphokine-Activated Killer Cell Activity

Stötter¹

1991

Arch Surg

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The T-cell growth factors interleukin 2 (IL-2) and interleukin 7 (IL-7) induce lymphokine-activated killer (LAK) cell activity in short-term cultures of human peripheral blood mononuclear cells. Interleukin 4 (IL-4), another T-cell growth factor, induces LAK cell activity in IL-2-prestimulated lymphocytes only and inhibits LAK cell generation in normal peripheral blood mononuclear cells. Our studies of the processes involved using 21-mer phosphorothioate antisense oligonucleotides to the sequence adjacent to the start codon of IL-2 mRNA or IL-4 mRNA (effective concentration, 5 to 10 mumol/L) and cyclosporine (0.01 to 1.0 microgram/mL) or FK506 (0.01 to 1.0 ng/mL) demonstrate that IL-7-induced LAK cell activity is independent of IL-2 production and is regulated by endogenously generated IL-4. Like IL-2, IL-7 stimulated production of tumor necrosis factor alpha, but we failed to detect interferon gamma in IL-7-stimulated cultures. The implication of this regulatory feedback in IL-7-induced LAK cell generation for clinical applications is discussed.

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Regulation of T cell proliferation by IL-7.

Cited by 94 publications

References 0 publications

Advances in IL-7 Research on Tumour Therapy

Advances in IL-7 Research on Tumour Therapy

Hyperexpression of Interleukin-7 Is Not Necessary or Sufficient for Transformation of a Pre-B Lymphoid Cell Line

Human Lymphokine-Activated Killer Cell Activity

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