Regulation of the formation and structure of biofilms by quorum sensing signal molecules packaged in outer membrane vesicles

Zhao, Zhenjun; Wang, Lianjie; Miao, Jiahui; Zhang, Ziyan; Ruan, Jingqi; Xu, Lijie; Guo, Haipeng; Zhang, Ming; Qiao, Weichuan

doi:10.1016/j.scitotenv.2021.151403

Cited by 46 publications

(21 citation statements)

References 53 publications

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“…Outer membrane vesicles (OMVs) are spherical nanoparticles with a lipid bilayer produced by blebbing of the bacterial outer membrane, containing a variety of lipids, sugars, DNA, RNA, and proteins. Depending on their content, which differs among P. aeruginosa strains ( 59 , 60 ), OMVs can be involved in diverse biological processes, such as horizontal gene transfer ( 61 – 63 ), protection against phages ( 64 ), cell-cell communication ( 65 ), biofilm architecture ( 66 , 67 ), antibiotic resistance ( 68 , 69 ), escape from the immune system ( 70 ), and delivery of virulence factors into host cells ( 71 ).…”

Section: Bacterial Lipids Acting As Virulence Factorsmentioning

confidence: 99%

Role of Host and Bacterial Lipids in Pseudomonas aeruginosa Respiratory Infections

et al. 2022

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The opportunistic pathogen Pseudomonas aeruginosa is one of the most common agents of respiratory infections and has been associated with high morbidity and mortality rates. The ability of P. aeruginosa to cause severe respiratory infections results from the coordinated action of a variety of virulence factors that promote bacterial persistence in the lungs. Several of these P. aeruginosa virulence mechanisms are mediated by bacterial lipids, mainly lipopolysaccharide, rhamnolipid, and outer membrane vesicles. Other mechanisms arise from the activity of P. aeruginosa enzymes, particularly ExoU, phospholipase C, and lipoxygenase A, which modulate host lipid signaling pathways. Moreover, host phospholipases, such as cPLA2α and sPLA2, are also activated during the infectious process and play important roles in P. aeruginosa pathogenesis. These mechanisms affect key points of the P. aeruginosa-host interaction, such as: i) biofilm formation that contributes to bacterial colonization and survival, ii) invasion of tissue barriers that allows bacterial dissemination, iii) modulation of inflammatory responses, and iv) escape from host defenses. In this mini-review, we present the lipid-based mechanism that interferes with the establishment of P. aeruginosa in the lungs and discuss how bacterial and host lipids can impact the outcome of P. aeruginosa respiratory infections.

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Section: Bacterial Lipids Acting As Virulence Factorsmentioning

confidence: 99%

Role of Host and Bacterial Lipids in Pseudomonas aeruginosa Respiratory Infections

et al. 2022

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“…Besides, Sun reported that C4-HSL was associated with biofilm formation through affecting EPS production ( Sun et al., 2018 ). Similarly, PQS was also found to promote the growth of biofilm since the addition of PQS increased the content of protein in EPS and biomass by upregulating the rhlRⅠ QS system, which was favorable for biofilm maturation ( Zhao et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Quorum sensing signals improve the power performance and chlortetracycline degradation efficiency of mixed-culture electroactive biofilms

et al. 2022

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“…[7] Outer membrane vesicles (OMVs) are naturally occurring, nonreplicating, highly immunogenic, spherical nanostructures that are shed from the surface of Gramnegative bacteria. [10][11][12] The diverse biological functions of OMVs include horizontal gene transfer, [13] delivering microRNAs [14] and virulence factors [15,16] into host cells, immune evasion by inactivating host defense factors, [17,18] resistance to antibiotics, [19] nutrient acquisition, [20] quorum sensing, [21] and stress responses. [22] Because they display an array of bacterial surface proteins, lipids, and carbohydrates, as well as cell wall components with adjuvant properties, several strategies have explored OMVs as an alternative to whole cell bacterial vaccines; [10][11][12]23,24] indeed, OMVs from Neisseria meningitidis serogroup B are included along with bacterial proteins from the pathogen in a multicomponent vaccine (Bexsero) that is approved for human use.…”

Section: Introductionmentioning

confidence: 99%

Outer Membrane Vesicle‐Coated Nanoparticle Vaccine Protects against Acinetobacter baumannii Pneumonia and Sepsis

Bjånes

Zhou

Qayum

et al. 2022

Advanced NanoBiomed Research

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The highly multidrug‐resistant (MDR) Gram‐negative bacterial pathogen Acinetobacter baumannii is a top global health priority where an effective vaccine can protect susceptible populations and limit resistance acquisition. Outer membrane vesicles (OMVs) shed from Gram‐negative bacteria are enriched with virulence factors and membrane lipids but heterogeneous in size and cargo. Herein, a vaccine platform combining precise and replicable nanoparticle technology with immunogenic A. baumannii OMVs (Ab‐OMVs) is reported. Gold nanoparticle cores coated with Ab‐OMVs (Ab‐NPs) induce robust IgG titers in rabbits that enhance human neutrophil opsonophagocytic killing and passively protect against lethal A. baumannii sepsis in mice. Active Ab‐NP immunization in mice protects against sepsis and pneumonia, accompanied by B cell recruitment to draining lymph nodes, activation of dendritic cell markers, improved splenic neutrophil responses, and mitigation of proinflammatory cytokine storm. Nanoparticles are an efficient and efficacious platform for OMV vaccine delivery against A. baumannii and perhaps other high‐priority MDR pathogens.

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Regulation of the formation and structure of biofilms by quorum sensing signal molecules packaged in outer membrane vesicles

Cited by 46 publications

References 53 publications

Role of Host and Bacterial Lipids in Pseudomonas aeruginosa Respiratory Infections

Role of Host and Bacterial Lipids in Pseudomonas aeruginosa Respiratory Infections

Quorum sensing signals improve the power performance and chlortetracycline degradation efficiency of mixed-culture electroactive biofilms

Outer Membrane Vesicle‐Coated Nanoparticle Vaccine Protects against Acinetobacter baumannii Pneumonia and Sepsis

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