Regulation of the immune response. I. Regulatory cell equilibrium in the “virgin” state

Kelsoe, Garnett; Černý, Jan

doi:10.1002/eji.1830080307

Cited by 12 publications

(2 citation statements)

References 13 publications

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“…It has been shown that native serum immunoglobulins are part of a normal humoral immune response against bacterial flora and food antigens (28). Furthermore, it has also been shown that the virgin humoral immune state is in a constant state of regulation, which influences the subsequent specific antibody response (13).…”

Section: Discussionmentioning

confidence: 99%

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Effect of Dietary Essential Amino Acid Limitations upon Native Levels of Murine Serum Immunoglobulins, Transferrin, and Complement

Petro

Bhattacharjee

1980

Infect Immun

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Effects of dietary essential amino acid (leucine, isoleucine, valine, or lysine) limitations upon the native levels of serum immunoglobulin G (IgG), IgM, and IgA, as well as transferrin, the third component of complement (C3), and albumin were determined in CF1 mice by the radial immunodiffusion technique. Male mice fed the control diet and the isoleucine- or valine-limited diets exhibited lower levels of serum IgG than the female mice fed the same diets. Levels of IgG in female experimental mice were not significantly different than those in female control mice. Serum IgM levels in male or female mice fed the experimental diets were higher than those in the control mice. Except for the mice fed the isoleucine-limited diet, serum IgA levels were higher in male and female mice fed the experimental diets than in mice fed the control diet. Serum transferrin levels were not significantly different in mice fed the experimental diets when compared with mice fed the control diet. However, the levels of transferrin found in the peritoneal exudates were lower in mice fed the isoleucine- or lysine-limited diets than in mice fed the control diet. In mice fed the isoleucine- and lysine-limited diets, the levels of serum C3 were significantly lower than those in control mice. These results indicate that the native levels of serum immunoglobulins are increased in some instances and that the levels of serum C3 and the transferrin in the peritoneal fluid are significantly decreased in certain dietary groups of mice.

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Section: Discussionmentioning

confidence: 99%

“…Although these results are conflicting, the effect of dietary essential amino acid limitations upon the synthesis of native serum immunoglobulins is not known. The native or virgin immune state of the host significantly affects the subsequent induced antibody levels (13).…”

mentioning

confidence: 99%

Effect of Dietary Essential Amino Acid Limitations upon Native Levels of Murine Serum Immunoglobulins, Transferrin, and Complement

Petro

Bhattacharjee

1980

Infect Immun

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Regulation of the T15 idiotype‐positive, T‐independent immune response to Streptococcus pneumoniae R36 a(Pn). I. Specific suppressor T cells induced by Pn in vitro are antigen‐specific and idiotype‐positive

1980

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Normal BALB/c spleen cells incubated for 2 days with Streptococcus pneumoniae R 36 a (Pn) vaccine in vitro acquired the specific ability to inhibit the T-independent anti-Pn response of fresh lymphocytes. The activated suppressor cells were susceptible to cytotoxic treatment with mouse anti-theta serum plus complement, and they inhibited the anti-Pn response of B lymphocytes deprived of T cells. The suppressive effect was eliminated by adsorbtion of cells on dishes coated with the C polysaccharide from Pn, and treatment of the suppressor cells with a rabbit antibody specific for TEPC-15 myeloma protein, in the presence of complement, abolished the suppressive effect. The results indicate that stimulation of lymphocytes with a T-independent antigen in vitro activates suppressor T cells bearing a specific antigen receptor that may express the idiotype(s) characteristic of anti-Pn antibody, and that these cells inhibit the Pn-reactive B cells directly.

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Presence in unprimed mice of helper T cells specific for antigens closely related to self and their possible relevance to tumor immunology

Pilarski¹

1981

Cellular Immunology

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Regulation of the immune response. I. Regulatory cell equilibrium in the “virgin” state

Cited by 12 publications

References 13 publications

Effect of Dietary Essential Amino Acid Limitations upon Native Levels of Murine Serum Immunoglobulins, Transferrin, and Complement

Effect of Dietary Essential Amino Acid Limitations upon Native Levels of Murine Serum Immunoglobulins, Transferrin, and Complement

Regulation of the T15 idiotype‐positive, T‐independent immune response to Streptococcus pneumoniae R36 a(Pn). I. Specific suppressor T cells induced by Pn in vitro are antigen‐specific and idiotype‐positive

Presence in unprimed mice of helper T cells specific for antigens closely related to self and their possible relevance to tumor immunology

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