Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective

Yang, Guan; Bibi, Shahida; Du, Min; Suzuki, Takuya; Zhu, Mei‐Jun

doi:10.1080/10408398.2016.1152230

Cited by 102 publications

(76 citation statements)

References 159 publications

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“…Additional studies are required to confirm this hypothesis. Although the exact mechanisms involved in the regulation of oral epithelial tight junction integrity have not been investigated, it may be associated with previously characterized polyphenol‐mediated regulatory pathways, including the protein kinase C pathway, in intestinal epithelial cells (Yang, Bibi, Du, Suzuki, & Zhu, ). Mechanistic studies are required to clarify this property of the tart cherry fraction.…”

Section: Discussionmentioning

confidence: 99%

“…* , significantly different from the control (p < .01). NDM-TCJ, nondialyzable material from tart cherry juice; NDM-TCP, nondialyzable material from tart cherry powder; TER, transepithelial electrical resistance epithelial cells (Yang, Bibi, Du, Suzuki, & Zhu, 2017). Mechanistic studies are required to clarify this property of the tart cherry fraction.…”

Section: Discussionmentioning

confidence: 99%

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Tart cherry (Prunus cerasus L.) fractions inhibit biofilm formation and adherence properties of oral pathogens and enhance oral epithelial barrier function

Lagha

LeBel

Grenier

2019

Phytotherapy Research

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Dental caries, candidiasis, and periodontal disease are the most common oral infections affecting a wide range of the population worldwide. The present study investigated the effects of two tart cherry (Prunus cerasus L.) fractions on important oral pathogens, including Candida albicans, Streptococcus mutans, and Fusobacterium nucleatum, as well as on the barrier function of oral epithelial cells. Procyanidins and quercetin and its derivatives were the most important constituents found in the tart cherry fractions. Although the fractions showed poor antimicrobial activity, they inhibited biofilm formation by the three oral pathogens in a dose‐dependent manner. The tart cherry fractions also attenuated the adherence of C. albicans and S. mutans to a hydroxylapatite surface as well as the adherence of F. nucleatum to oral epithelial cells. Treating oral epithelial cells with the tart cherry fractions significantly enhanced the barrier function as determined by monitoring the transepithelial electrical resistance. In conclusion, this study showed that the tart cherry fractions and their bioactive constituents could be promising antiplaque compounds by targeting biofilm formation and adherence properties of oral pathogens. Furthermore, its property of increasing the epithelial barrier function may protect against microbial invasion of the underlying connective tissue.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tart cherry (Prunus cerasus L.) fractions inhibit biofilm formation and adherence properties of oral pathogens and enhance oral epithelial barrier function

Lagha

LeBel

Grenier

2019

Phytotherapy Research

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“…This may explain why, in the present study, treating rats with DSS-induced colitis with the anti-inflammatory agents DTCM-G and DHME for only 5 days restored the densities of CgA, Neurog3- and NeuroD1-immunoreactive cells to those of the control group. The rapid proliferation and differentiation of epithelial cells are disturbed by inflammation, which causes impairment in epithelial barrier function (81–84). Polyphenols, which is quite different from DTCM-G and DHME, exert a protective effect on epithelial cells and consequently suppress the inflammatory response (81–83).…”

Section: Discussionmentioning

confidence: 99%

Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis

Umezawa

Hatlebakk

Gilja

2017

Molecular Medicine Reports

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The present study aimed to determine whether there is an association between abnormalities in enteroendocrine cells in dextran sulfate sodium (DSS)-induced colitis and the clonogenic and/or proliferative activities of stem cells. A total of 48 male Wistar rats were divided into four groups. Animals in the control group were provided with normal drinking water, whereas DSS colitis was induced in the remaining three groups. The rats with DSS-induced colitis were randomized into the following three groups: i) DSS group, which received 0.5 ml 0.5% carboxymethyl cellulose (CMC; vehicle); ii) DSS-G group, which was treated with 3-[(dodecylthiocarbonyl)-methyl]-glutarimide at 20 mg/kg body weight in 0.5% CMC; and iii) DSS-Q group, which was treated with dehydroxymethylepoxyquinomicin at 15 mg/kg body weight in 0.5% CMC. Treatments were administered intraperitoneally twice daily for 5 days in all groups. Subsequently, tissue samples from the colon were stained with hematoxylin-eosin, or immunostained for chromogranin A (CgA), Musashi 1 (Msi1), Math-1, neurogenin 3 (Neurog3) and neurogenic differentiation D1 (NeuroD1). The densities of CgA, Msi1-, Math-1-, Neurog3- and NeuroD1-immunoreactive cells were determined. DTCM-G, and DHMEQ ameliorated the inflammation in DSS-induced colitis. The density of CgA-, Neurog3- and NeuroD1-immunoreactive cells was significantly higher in the DSS group compared with in the control group, and the density of CgA cells was correlated with the densities of Neurog3- and NeuroD1-immunoreactive cells. There were no significant differences in the densities of Msi1- and Math-1-immunoreactive cells among the four experimental groups. The elevated densities of enteroendocrine cells detected in DSS-induced colitis may be due to the increased differentiation of early enteroendocrine progenitors during secretory lineage. It is probable that the DSS-induced inflammatory processes trigger certain signaling pathways, which control differentiation of the stem-cell secretory lineage into mature enteroendocrine cells.

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“…The intestinal barrier plays a vital role in maintaining intestinal homeostasis, which is composed of the apical cell membrane and intercellular tight junctions (TJs) of enterocytes (Anderson and Van Itallie ). Therefore, an intact intestinal mucosal barrier is very important in both ensuring adequate provision of nutrients to the whole body and preventing gut‐related diseases (Yang and others ). In fact, dietary ingredient can affect mucosal barrier function, such as amino acid and phenolic acid (Wang and others ; Ruan and others ).…”

Section: Introductionmentioning

confidence: 99%

Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO‐1 in Intestine

Liu

Ruan

et al. 2017

Journal of Food Science

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Dietary amino acids provide various beneficial effects for our health. The aim of the present study was to assess the effects of tryptophan (Trp) supplementation on barrier function. Ninety-six healthy finishing pigs (initial body weight 51.49 ± 1.12 kg) were randomly allocated into 2 treatment groups, control group, and 0.2% Trp group. The control group was fed the basal diet, and 0.2% Trp group was fed basal diet plus 0.2% Trp. The trial period is 60 d. Compared with control group, the mRNA abundance of claudin-3 and zonula occluden-1 (ZO-1) in the jejunum in 0.2% Trp group (P < 0.05) was increased. According to immunohistochemistry and immunoblotting test, the expression of ZO-1 in jejunum in 0.2% Trp group was also significantly increased compared with the control group (P < 0.05). These results revealed that Trp enhanced the expression of tight junction protein ZO-1 in the intestine of pig model. Trp may be potential and beneficial dietary functional factor for regulating the intestinal development and inhibiting intestinal aging.

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Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective

Cited by 102 publications

References 159 publications

Tart cherry (Prunus cerasus L.) fractions inhibit biofilm formation and adherence properties of oral pathogens and enhance oral epithelial barrier function

Tart cherry (Prunus cerasus L.) fractions inhibit biofilm formation and adherence properties of oral pathogens and enhance oral epithelial barrier function

Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis

Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO‐1 in Intestine

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