Regulation of the rate of synthesis of messenger ribonucleic acid by growth hormone

ANABOLIC ACTION OF GROWTH HORMONE*

“…There is abundant evidence of the ability of growth hormone to stimulate RNA synthesis in rat liver and other tissues (Di Stefan0 & Diermeier, 1959;Talwar et al, 1962;Korner, 1964), so with Dr. A. E. Pegg, the effect of growth hormone on the RNA polymerase enzyme of rat liver nuclei was studied. As we have reported (Pegg & Korner, 1965), and as has been confirmed (Widnell & Tata, 1966), administration of growth hormone to rats results in stimulation of the activity of the RNA polymerase enzyme, assayed in isolated…”

ANDROGEN-DEPENDENT SYNTHESIS OF α2u GLOBULIN IN THE RAT: ROLE OF THE PITUITARY GLAND

“…For example, the stimulatory effects of growth hormone on hepatic protein synthesis (Jefferson & Körner, 1967;Kernoff, Pimstone, Solomon & Brock, 1971) and on hepatic ribosome synthesis (Körner, 1964), stimulation of the hepatic endoplasmic reticulum and ribosome synthesis by thyroxine (Tata, 1968), and stimulation of hepatic ribosome synthesis by glucocorticoids (Greenman, Wicks & Kenney, 1965), have all been well investigated. Thus, the secondary hormonal mediators which are required for the hepatic synthesis of a2U globulin (i.e.…”

The Action of Growth and Developmental Hormones

“…In turn, transcription experiments revealed that sex steroids, thyroid hormones, GH, glucocorticoids, and ecdysone all stimulated nuclear RNA synthesis in vivo as well as in isolated nuclei (Hamilton, 1963;Tata, 1963Tata, , 1964bTomkins and Maxwell, 1963;Vi and Mueller, 1963;Tata, 1963, 1966;Gorski, 1964;Korner, 1964;Williams-Ashman et al, 1964;Kenney et al, 1965;Sekeris, 1965;see Tata, 1970). These studies also demonstrated that increased transcriptional activity of target cell nuclei preceded the hormone-induced change in translational activity in the cytoplasm.…”