2022
DOI: 10.3389/fimmu.2022.848577
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Regulation of the Signal-Dependent E Protein HEBAlt Through a YYY Motif Is Required for Progression Through T Cell Development

Abstract: The E protein transcription factors E2A and HEB are critical for many developmental processes, including T cell development. We have shown that the Tcf12 locus gives rise to two distinct HEB proteins, with alternative (HEBAlt) and canonical (HEBCan) N-terminal domains, which are co-expressed during early T cell development. While the functional domains of HEBCan have been well studied, the nature of the HEBAlt-specific (Alt) domain has been obscure. Here we provide compelling evidence that the Alt domain provi… Show more

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Cited by 1 publication
(4 citation statements)
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“…Interestingly, HEBAlt is preferentially produced in the DN and ISP stages. Since E proteins are known to inhibit cell proliferation and HEBAlt acts as a hypomorph ( 13 , 30 ), whether HEBAlt plays a role in tampering E protein activities during pre-TCR-triggered cell expansion is interesting to be investigated.…”
Section: T Cell Developmentmentioning
confidence: 99%
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“…Interestingly, HEBAlt is preferentially produced in the DN and ISP stages. Since E proteins are known to inhibit cell proliferation and HEBAlt acts as a hypomorph ( 13 , 30 ), whether HEBAlt plays a role in tampering E protein activities during pre-TCR-triggered cell expansion is interesting to be investigated.…”
Section: T Cell Developmentmentioning
confidence: 99%
“…The HEB gene encodes a full-length canonical protein (HEBCan) and a truncated alternate form (HEBAlt), which derives from a transcript initiated in the middle of the gene ( 12 ). HEBAlt lacks the AD1 transcription activation domain and has lower transcriptional activities ( 13 ). It has an Alt domain at the N-terminus with three tyrosine residues which can be modified by phosphorylation that augments its transcriptional activity ( 13 ).…”
Section: Introductionmentioning
confidence: 99%
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