Regulation of tumorigenesis and metastasis of hepatocellular carcinoma tumor endothelial cells by microRNA-3178 and underlying mechanism

Li, Wei; Shen, Shuxin; Wu, Shanmin; Chen, Zubing; Hu, Chao; Yan, Rui-Chen

doi:10.1016/j.bbrc.2015.07.057

Cited by 22 publications

(17 citation statements)

References 32 publications

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“…It is not expressed in brain [26]. Expression studies in 15 hepatocellular carcinoma (HCC) suggest a role of MIR-3178 as a tumor suppressor by inhibiting cell proliferation, angiogenesis, invasion, and migration of HCC tumor endothelial cells [27].…”

Section: Discussionmentioning

confidence: 99%

A new microdeletion syndrome involving TBC1D24, ATP6V0C, and PDPK1 causes epilepsy, microcephaly, and developmental delay

Mucha

Banka

Ajeawung

et al. 2019

Genetics in Medicine

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Section: Discussionmentioning

confidence: 99%

A new microdeletion syndrome involving TBC1D24, ATP6V0C, and PDPK1 causes epilepsy, microcephaly, and developmental delay

Mucha

Banka

Ajeawung

et al. 2019

Genetics in Medicine

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“…Interestingly, there were tumor suppressors present, such as miRNA 3178 in hepatocellular carcinoma [54] and miRNA 4792 in nasopharyngeal carcinoma [55]. However, there were also regulatory sequences that promote tumor proliferation and migration.…”

Section: Discussionmentioning

confidence: 99%

Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells – Liquid biopsies for monitoring complications of pregnancy

et al. 2017

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Our understanding of how cells communicate has undergone a paradigm shift since the recent recognition of the role of exosomes in intercellular signaling. In this study, we investigated whether oxygen tension alters the exosome release and miRNA profile from extravillous trophoblast (EVT) cells, modifying their bioactivity on endothelial cells (EC). Furthermore, we have established the exosomal miRNA profile at early gestation in women who develop pre-eclampsia (PE) and spontaneous preterm birth (SPTB). HTR-8/SVneo cells were used as an EVT model. The effect of oxygen tension (i.e. 8% and 1% oxygen) on exosome release was quantified using nanocrystals (Qdot®) coupled to CD63 by fluorescence NTA. A real-time, live-cell imaging system (Incucyte™) was used to establish the effect of exosomes on EC. Plasma samples were obtained at early gestation (<18 weeks) and classified according to pregnancy outcomes. An Illumina TrueSeq Small RNA kit was used to construct a small RNA library from exosomal RNA obtained from EVT and plasma samples. The number of exosomes was significantly higher in EVT cultured under 1% compared to 8% oxygen. In total, 741 miRNA were identified in exosomes from EVT. Bioinformatic analysis revealed that these miRNA were associated with cell migration and cytokine production. Interestingly, exosomes isolated from EVT cultured at 8% oxygen increased EC migration, whilst exosomes cultured at 1% oxygen decreased EC migration. These changes were inversely proportional to TNF-α released from EC. Finally, we have identified a set of unique miRNAs in exosomes from EVT cultured at 1% oxygen and exosomes isolated from the circulation of mothers at early gestation, who later developed PE and SPTB. We suggest that aberrant exosomal signalling by placental cells is a common aetiological factor in pregnancy complications characterised by incomplete SpA remodeling and is therefore a clinically relevant biomarker of pregnancy complications.

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“…30 Among the miRNAs, miR-3178 has been reported to regulate tumorigenesis and metastasis of hepatocellular carcinoma tumor endothelial cells via targeting early growth responsive gene 3 (EGR3). 31 Altered expression profile of microRNAs in gastric stromal tumor has revealed that miR-3178 function as suppressive microRNAs and may become a diagnosis and treatment strategy for gastric stromal tumor. 32 In this study, we explored the effects of miR-3178 on gastric mucosal epithelial GES-1 cells with inflammatory stimulation by Tip-α and on the target TRAF3.…”

Section: Rudolfmentioning

confidence: 99%

“…They are important regulators in organism development and causes of human diseases such as inflammation and cancer . Among the miRNAs, miR‐3178 has been reported to regulate tumorigenesis and metastasis of hepatocellular carcinoma tumor endothelial cells via targeting early growth responsive gene 3 (EGR3) . Altered expression profile of microRNAs in gastric stromal tumor has revealed that miR‐3178 function as suppressive microRNAs and may become a diagnosis and treatment strategy for gastric stromal tumor .…”

mentioning

confidence: 99%

MicroRNA‐3178 ameliorates inflammation and gastric carcinogenesis promoted by Helicobacter pylori new toxin, Tip‐α, by targeting TRAF3

et al. 2016

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Regulation of tumorigenesis and metastasis of hepatocellular carcinoma tumor endothelial cells by microRNA-3178 and underlying mechanism

Cited by 22 publications

References 32 publications

A new microdeletion syndrome involving TBC1D24, ATP6V0C, and PDPK1 causes epilepsy, microcephaly, and developmental delay

A new microdeletion syndrome involving TBC1D24, ATP6V0C, and PDPK1 causes epilepsy, microcephaly, and developmental delay

Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells – Liquid biopsies for monitoring complications of pregnancy

MicroRNA‐3178 ameliorates inflammation and gastric carcinogenesis promoted by Helicobacter pylori new toxin, Tip‐α, by targeting TRAF3

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