2010
DOI: 10.1186/1471-2199-11-9
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Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells

Abstract: BackgroundUDP-glucuronosyltransferase 1A1 (UGT1A1) is a pivotal enzyme involved in metabolism of SN-38, the active metabolite of irinotecan commonly used to treat metastatic colorectal cancer. We previously demonstrated aberrant methylation of specific CpG dinucleotides in UGT1A1-negative cells, and revealed that methylation state of the UGT1A1 5'-flanking sequence is negatively correlated with gene transcription. Interestingly, one of these CpG dinucleotides (CpG -4) is found close to a HNF1 response element … Show more

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Cited by 75 publications
(59 citation statements)
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“…Our study was accomplished in a novel information-thermodynamics framework for methylome analysis where two magnitudes were used: (1) the amount of information gained/lost (I R ) with the CDM changes processed by the methylation machinery in a genomic region (GR) R (Equation (1), see material and method section) and (2) the uncertainty of not observing a SNP (LC R , Equation (3)). The physical basis of the amount of information I R has been described in the Introduction and is documented in a recent publication [11].…”
Section: Resultsmentioning
confidence: 99%
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“…Our study was accomplished in a novel information-thermodynamics framework for methylome analysis where two magnitudes were used: (1) the amount of information gained/lost (I R ) with the CDM changes processed by the methylation machinery in a genomic region (GR) R (Equation (1), see material and method section) and (2) the uncertainty of not observing a SNP (LC R , Equation (3)). The physical basis of the amount of information I R has been described in the Introduction and is documented in a recent publication [11].…”
Section: Resultsmentioning
confidence: 99%
“…The numerical scale for each heatmap of I R is close to the range of values estimated from the experimental data according to Equation (1). The gradient of color scale is then constrained, in each case, to the maximum and minimum numerical values of I R .…”
Section: Heatmapsmentioning
confidence: 99%
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“…Discussão O HNF1, também conhecido por HNF1A (Hepatocyte Nuclear Factor 1 -Alpha) e TCF-1 (Transcription Factor 1) codifica um FT requerido para a expressão de diversos genes específicos do fígado. Esse gene tem sido relacionado a doenças (segundo uma extensa literatura) como diabetes, incluindo diabetes mellitus tipo I e II, diabetes gestacional e (Harries et al, 2006;Narayana et al, 2006;Rowley et al, 2006;Maraschin et al, 2008;Umeyama et al, 2009;Pal et al, 2010;Pinés Corrales et al, 2010), doenças renais (Malecki et al, 2005), adenoma (Bluteau et al, 2002;Laurent-Puig et al, 2003), câncer de mama, de endométrio e de ovário (Rebouissou et al, 2004), neoplasias colorretais (Jeannot et al, 2006;Bélanger et al, 2010) e neoplasias de esôfago (Piessen et al, 2007).…”
Section: Discussionunclassified