Regulatory B cells correlate with HIV disease progression

Jiao, Yanmei; Wang, Xi; Zhang, Tong; Sun, Lijun; Wang, Rui; Li, Wei; Ji, Yaying; Wu, Hao; Liu, Cuie

doi:10.1111/1348-0421.12171

Cited by 16 publications

(18 citation statements)

References 33 publications

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“…identified Breg cells in HIV infection as CD19+CD24 hi CD38 hi CD5+ and reported their positive correlation with viral load and negative correlation with CD4+ T cell count. These findings suggest that CD1d is not a marker of Breg cells in this viral infection, which may be supported by reports of CD1d down‐regulation by HIV‐1 virus .…”

Section: Breg In Viral Infectionssupporting

confidence: 77%

Regulatory B cell phenotype and mechanism of action: the impact of stimulating conditions

Wąsik

Nazimek

Bryniarski

2018

Microbiology and Immunology

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A diverse population of regulatory B (Breg) cells reportedly exhibits significant immunomodulatory effects in various models of inflammatory responses and infectious diseases caused by bacteria, viruses or parasites. Breg cells contribute to maintenance of homeostasis via IL-10 production and multiple IL-10-independent mechanisms. The current review describes various phenotypic and functional subsets of Breg cells in autoimmune and infectious diseases and discusses the impacts of experimental conditions that have been found to drive Breg cell differentiation.

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Section: Breg In Viral Infectionssupporting

confidence: 77%

Regulatory B cell phenotype and mechanism of action: the impact of stimulating conditions

Wąsik

Nazimek

Bryniarski

2018

Microbiology and Immunology

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“…Treatment with cART resulted in an increase in CD5 + B cells. Jiao et al found that the proportion of CD5 + cells did not correlate with HIV viral replication . It would appear that CD5 + B cells respond differently to HIV infection than transitional B cells, although both phenotypes are enriched with B10 cells.…”

Section: Discussionmentioning

confidence: 99%

Increased proportions of B cells with spontaneous production of interleukin‐10 in HIV‐infected individuals are normalized during combination antiretroviral therapy: a longitudinal study

Sambleben

Knudsen

Hartling

et al. 2017

APMIS

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Interleukin-10 (IL-10)-producing B cells (B10 cells) may inhibit HIV-specific T cells and are elevated in untreated HIV infection. We aimed to determine the effect of combination antiretroviral treatment (cART) on the proportion of B10 cells. Furthermore, we compared B10-cell proportions in HIV-infected progressors and viremic controllers. This was a prospective study including HIV-infected progressors, viremic controllers and healthy controls. Progressors initiating cART were followed for 6 months. Purified B cells were stimulated with CpG, alone or in combination with HIV gp120, and the proportion of B10 cells was measured by flow cytometry. Without stimulation, the B10-cell proportion was higher in progressors than in healthy controls, while viremic controllers and healthy controls had comparable proportions. Moreover, the proportion of CD24 CD38 transitional B cells was higher in progressors than in healthy controls. After initiation of cART, the proportion of B10 cells and transitional B cells decreased. In conclusion, progressors had elevated B10-cell proportions, while viremic controllers displayed normal proportions. After initiation of cART, the B10-cell proportion decreased. This could limit B10-cell-mediated suppression of specific CD8 T-cell responses.

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“…Generally, the established Breg subsets in humans include CD19 + CD24 + CD38 + Bregs (1,2,20,21) and CD19 + CD24 + CD27 + Bregs (22), although reports have also included the identification of CD19 + CD5 + CD1d + Bregs (23,24) and CD19 + TIM-1 + Bregs (17) in humans. However, certain phenotypes are not supported by evidence in human immunodeficiency virus (HIV)-infected individuals, which suggests human ‘Bregs’ lacking the expression of CD1d may not be Bregs.…”

Section: Breg Phenotypesmentioning

confidence: 99%

“…Although IL-10 is produced by various cell types and exhibits several pleiotropic effects, the expression of IL-10 by human and mouse Bregs is central to their negative regulation of adaptive and innate immune responses (1–3,5,15,20,22,25). …”

Section: Immunomodulation By Bregsmentioning

confidence: 99%

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Regulatory B cells in infectious disease

Dai

Zhong

2017

Molecular Medicine Reports

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Regulatory B cells (Bregs) are a subset of B cells, which reportedly exert significant immunomodulatory effects through the production of interleukin (IL)-10, IL-35 and transforming growth factor-β. Over the last decade, studies have indicated that Bregs function in autoimmune and allergic diseases through antigen-specific and non-specific immunoregulatory mechanisms. However, only a limited number of reviews have focused on the role of Bregs during infection, particularly their functions in intracellular infections. The present review discusses the role of Bregs in infectious diseases in animal models and human studies, and provides an overview of the immunoregulatory mechanisms used by Bregs.

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Regulatory B cells correlate with HIV disease progression

Cited by 16 publications

References 33 publications

Regulatory B cell phenotype and mechanism of action: the impact of stimulating conditions

Regulatory B cell phenotype and mechanism of action: the impact of stimulating conditions

Increased proportions of B cells with spontaneous production of interleukin‐10 in HIV‐infected individuals are normalized during combination antiretroviral therapy: a longitudinal study

Regulatory B cells in infectious disease

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