Regulatory Effect of Sea-Buckthorn Procyanidins on Oxidative Injury HUVECs

Lin, Xiao; Yuen, Michael; Yuen, Tina; Yuen, Hywel; Wang, Min; Peng, Qiang

doi:10.3389/fnut.2022.850076

Cited by 7 publications

(8 citation statements)

References 27 publications

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“…They have potential therapeutic benefits in various diseases such as cerebral ischemia, Alzheimer's disease, and cerebrovascular diseases [8,26,27]. The key role of PCs in the prevention of cardiovascular and cerebrovascular diseases is their contribution to the stabilization of the antioxidant system [26]. The results of our present study revealed that PCs dramatically protected nerve function and reduced cerebral infarct volume and pathological lesions in vivo, similar to a previous report [8].…”

Section: Discussionsupporting

confidence: 90%

“…Procyanidins (PCs) are natural biological polyphenols with the effects of anti-oxidation, anti-apoptosis, and the inhibition of inflammation. They have potential therapeutic benefits in various diseases such as cerebral ischemia, Alzheimer's disease, and cerebrovascular diseases [8,26,27]. The key role of PCs in the prevention of cardiovascular and cerebrovascular diseases is their contribution to the stabilization of the antioxidant system [26].…”

Section: Discussionmentioning

confidence: 99%

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Procyanidins Alleviated Cerebral Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via the Nrf2/HO-1 Signaling Pathway

et al. 2023

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Procyanidins (PCs), which are organic antioxidants, suppress oxidative stress, exhibit anti−apoptotic properties, and chelate metal ions. The potential defense mechanism of PCs against cerebral ischemia/reperfusion injury (CIRI) was investigated in this study. Pre−administration for 7 days of a PC enhanced nerve function and decreased cerebellar infarct volume in a mouse middle cerebral artery embolization paradigm. In addition, mitochondrial ferroptosis was enhanced, exhibited by mitochondrial shrinkage and roundness, increased membrane density, and reduced or absent ridges. The level of Fe2+ and lipid peroxidation that cause ferroptosis was significantly reduced by PC administration. According to the Western blot findings, PCs altered the expression of proteins associated with ferroptosis, promoting the expression of GPX4 and SLC7A11 while reducing the expression of TFR1, hence inhibiting ferroptosis. Moreover, the treatment of PCs markedly elevated the expression of HO−1 and Nuclear−Nrf2. The PCs’ ability to prevent ferroptosis due to CIRI was decreased by the Nrf2 inhibitor ML385. Our findings showed that the protective effect of PCs may be achieved via activation of the Nrf2/HO-1 pathway and inhibiting ferroptosis. This study provides a new perspective on the treatment of CIRI with PCs.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Procyanidins Alleviated Cerebral Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via the Nrf2/HO-1 Signaling Pathway

et al. 2023

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Section: Resultsmentioning

confidence: 85%

“…The research results showed H. rhamnoides L. could be used for 12 h by HUVECs and had no detectable cytotoxicity. The different concentrations of H. rhamnoides L. increased the mitochondrial membrane potential and NO level and decreased LDH leakage in a dose−effect relationship, which indicated H. rhamnoides L. improved oxidative damage 77. H. rhamnoides L. polysaccharide possessed moderate antioxidant activity, and its clearance rate of O 2 − • was 18.92% higher than that of V C when the polysaccharide concentration was 1200 μg/mL.…”

mentioning

confidence: 87%

Hippophae rhamnoides L.: A Comprehensive Review on the Botany, Traditional Uses, Phytonutrients, Health Benefits, Quality Markers, and Applications

Huang

et al. 2023

J. Agric. Food Chem.

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Hippophae rhamnoides L. (sea buckthorn), consumed as a food and health supplement worldwide, has rich nutritional and medicinal properties. Different parts of H. rhamnoides L. were used in traditional Chinese medicines for relieving cough, aiding digestion, invigorating blood circulation, and alleviating pain since ancient times. Phytochemical studies revealed a wide variety of phytonutrients, including nutritional components (proteins, minerals, vitamins, etc.) and functional components like flavonoids (1− 99), lignans (100−143), volatile oils (144−207), tannins (208−230), terpenoids (231−260), steroids (261−270), organic acids (271−297), and alkaloids (298−305). The pharmacological studies revealed that some crude extracts or compounds of H. rhamnoides L. demonstrated various health benefits, such as anti-inflammatory, antioxidant, hepatoprotective, anticardiovascular disease, anticancer, hypoglycemic, hypolipidemic, neuroprotective, antibacterial activities, and their effective doses and experimental models were summarized and analyzed in this paper. The quality markers (Q-markers) of H. rhamnoides L. were predicted and analyzed based on protobotanical phylogeny, traditional medicinal properties, expanded efficacy, pharmacokinetics and metabolism, and component testability. The applications of H. rhamnoides L. in juice, wine, oil, ferment, and yogurt were also summarized and future prospects were examined in this review. However, the mechanism and structure−activity relationship of some active compounds are not clear, and quality control and potential toxicity are worth further study in the future.

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“…Their antioxidant capacity is 40 times greater than that of vitamin C or E [12] . Due to their natural antioxidant properties, PACs have been suggested as a possible protector against oxidative stress damage to various organs and tissues, including the ovaries [14][15][16] . Research has shown that PACs can effectively mitigate pathological changes in granulosa cells by inhibiting autophagy and apoptosis, which ultimately contributes towards delaying ovarian aging [17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

The role of Procyanidins in delaying the Premature Ovarian Insufficiency through regulatory Sirt1-p53-p21 signaling Pathway in Female Germline Stem Cells

Ling

Dai

et al. 2023

Preprint

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As women age, their ovarian follicle pool naturally declines. However, female germline stem cells (FGSCs) possess a unique ability to differentiate into oocytes and continuously self-renew, providing an effective means of delaying ovarian aging by replenishing the primordial follicle pool. Therefore, activating FGSCs is critical in reshaping and safeguarding ovarian function. In this study, we investigated the biological activity of proanthocyanidins (PACs), natural antioxidants that exhibit anti-aging and anti-inflammatory properties beneficial for both male and female reproduction. Our in vivo and in vitro experiments demonstrate that PACs promote FGSCs proliferation while delaying ovarian aging. Specifically, PACs increase the number of primordial follicles, primary follicles, corpus luteum while reducing cystic follicles, and elevate estradiol(E2) levels along with anti-mullerian hormone(AMH) concentration levels in mice. Additionally, PACs significantly boost FGSC proliferation time- and dose-dependently by upregulating mRNA & protein expressions for FGSC-specific markers such as Mvh and Oct-4 while downregulating p53/p21 via activation of Sirt1 signaling pathway. The effects of PACS on FGCS were found to be impeded by the Sirt1 inhibitor EX527.Overall, this research provides strong evidence suggesting that PACS delay premature ovarian failure through regulating the Sirt1-p53-p21 signaling pathway involving female germline stem cells.

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Regulatory Effect of Sea-Buckthorn Procyanidins on Oxidative Injury HUVECs

Cited by 7 publications

References 27 publications

Procyanidins Alleviated Cerebral Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via the Nrf2/HO-1 Signaling Pathway

Procyanidins Alleviated Cerebral Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via the Nrf2/HO-1 Signaling Pathway

Hippophae rhamnoides L.: A Comprehensive Review on the Botany, Traditional Uses, Phytonutrients, Health Benefits, Quality Markers, and Applications

The role of Procyanidins in delaying the Premature Ovarian Insufficiency through regulatory Sirt1-p53-p21 signaling Pathway in Female Germline Stem Cells

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