2015
DOI: 10.1016/j.jep.2015.03.011
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Regulatory effect of Traditional Chinese Medicinal Formula Zuo-Gui-Wan on the Th17/Treg paradigm in mice with bone loss induced by estrogen deficiency

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Cited by 38 publications
(30 citation statements)
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“…However, after BSNXD and estrogen treatments, CTLA-4 + Tregs were increased, suggesting a potential inhibitory role of BSNXD and estrogen on osteoclast maturation. Foxp3 is the transcriptional factor for Tregs and many studies have been conducted on the interaction between Foxp3 + Tregs and the bone (37,38). In this study, we found that estrogen increased the numbers of Foxp3 + Tregs.…”
Section: Protection Of Tregs On Bonesupporting
confidence: 61%
“…However, after BSNXD and estrogen treatments, CTLA-4 + Tregs were increased, suggesting a potential inhibitory role of BSNXD and estrogen on osteoclast maturation. Foxp3 is the transcriptional factor for Tregs and many studies have been conducted on the interaction between Foxp3 + Tregs and the bone (37,38). In this study, we found that estrogen increased the numbers of Foxp3 + Tregs.…”
Section: Protection Of Tregs On Bonesupporting
confidence: 61%
“…Liu-wei-di-huang-wan was found to possess anti-osteoporosis effects by reducing apoptosis in osteoblast precursor cells (Li et al, 2010). Zuo-Gui-Wan was recently found to efficiently prevent bone loss in mice with bone loss induced by estrogen deficiency (Lai et al, 2015). Taken together, these ten most commonly prescribed formulas contain ingredients that can inhibit inflammation, relieve pain and anti-osteoporosis, and perform other functions.…”
Section: Discussionmentioning
confidence: 99%
“…E2 was shown to decrease the serum level of IL-17, inhibit Th17 differentiation, and hamper disease progression in the context of EAE [11]. In ovariectomized mice, Th17 cell proportion was markedly increased and negatively correlated with E2 levels in serum [17]. However, the effects of estrogens on the Th17 cell response in the experimental colitis have been scarcely studied.…”
Section: Introductionmentioning
confidence: 99%