Regulatory Network after Intracerebral Hemorrhage

Abstract

Intracerebral hemorrhage (ICH) has a high mortality and disability rate. As it is difficult to obtain brain tissue of patients occurred ICH, the mechanism research carried out primarily through animal experiments, and the translational medicine progresses slowly. More effective therapeutic targets and reliable regulatory networks for ICH are needed. We detected the expression levels of mRNAs, miRNAs and circRNAs before and after ICH, then added lncRNAs to obtain a more complete regulatory network. Subsequently, an original mRNA data in human peripheral blood after ICH from the GEO database was obtained. After analyzing the differential expressed mRNAs of the data, it was intersected with the mouse data. Then seven genes have been found to have made significant changes in both humans and mice after ICH. Finally, these gene regulatory networks in humans were analyzed. By comparing species, we provided signaling pathways for the human and mouse homologous in these regulatory networks. Hoped that some of them might become early warning signals of the ICH. Finally, the tendency of change in RNA levels of the above seven genes was checked after ICH in the mouse brain, in order to provide more valuable data.