Rationale: Colorectal cancer is the second leading cause of cancer-related deaths in the world. About 50% of patients will have metastases during the course of the disease. The common sites of metastasis are the liver, lung, peritoneum, lymph, etc. Metastatic carcinoma to the testes is uncommon. We found a case of ascending colon cancer metastasized to the testis in the clinic. Patient concerns: We reported a 50-year-old male patient who was found to have testicular metastases >4 years after intestinal cancer surgery, and multiple metastases in the peritoneum and pelvis were found 1 week later. Diagnoses: After enhanced computed tomography and pathological biopsy, the patient was diagnosed with testicular metastasis of colon cancer. Interventions: Capecitabine combined with bevacizumab is currently undergoing palliative treatment. Outcomes: The patients died of tumor progression on June 28, 2021. Lessons: The testicular metastasis of colorectal cancer is a sign of peritoneum and multiple metastases. When the testicular metastasis occurs in colorectal cancer patients, it usually indicates that the patient has a poor prognosis.

Rationale: Colon carcinoma is the most common type of cancer, and a leading cause of cancer-related death. Clinically, the most common sites of metastases from colon carcinoma are the liver, lungs, peritoneum, and lymph nodes, while the incidence of metastases to the prostate is low. There are few relevant studies on colon carcinoma, most of them being case reports. Patient concerns: A 76-year-old man treated with radical resection of right colon carcinoma due to primary poorly differentiated adenocarcinoma of the cecum. Postoperative pathological examination suggested that he had cancer at the junction of the ascending colon and the cecum. He had received adjuvant chemotherapy after surgery. One year later, he received transurethral plasma resection of the prostate due to urinary system discomfort. Postoperative pathological immunohistochemistry suggested prostate metastasis of colorectal carcinoma, and he received individualized treatment, but this produced no clear survival benefit. Diagnoses: Ascending colon cecal junction carcinoma with prostate metastasis. Interventions: Radical resection, chemotherapy, anti-androgen therapy, surgery to relieve primary lesion obstruction symptoms, and local radiotherapy of the prostate. Outcomes: At present, clinical cases of colon carcinoma with prostate metastasis are rare. By sharing a rare case of ascending colon cecal junction carcinoma with prostate metastasis and reviewing the relevant literature, this paper explores and optimizes the clinical treatment of colon carcinoma with prostate metastasis.

Intracerebral hemorrhage (ICH) has a high mortality and disability rate. As it is difficult to obtain brain tissue of patients occurred ICH, the mechanism research carried out primarily through animal experiments, and the translational medicine progresses slowly. More effective therapeutic targets and reliable regulatory networks for ICH are needed. We detected the expression levels of mRNAs, miRNAs and circRNAs before and after ICH, then added lncRNAs to obtain a more complete regulatory network. Subsequently, an original mRNA data in human peripheral blood after ICH from the GEO database was obtained. After analyzing the differential expressed mRNAs of the data, it was intersected with the mouse data. Then seven genes have been found to have made significant changes in both humans and mice after ICH. Finally, these gene regulatory networks in humans were analyzed. By comparing species, we provided signaling pathways for the human and mouse homologous in these regulatory networks. Hoped that some of them might become early warning signals of the ICH. Finally, the tendency of change in RNA levels of the above seven genes was checked after ICH in the mouse brain, in order to provide more valuable data.