Regulatory Non-coding RNAs Network in Non-alcoholic Fatty Liver Disease

Sulaiman, Siti Aishah; Muhsin, Nor I.A.; Jamal, A. Rahman A.

doi:10.3389/fphys.2019.00279

Cited by 52 publications

(59 citation statements)

References 141 publications

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“…[1][2][3][4] Hepatic lipid metabolism is tightly regulated through a delicate interplay of hormones (such as insulin), nuclear receptors (such as LXR), numerous cellular signalling pathways (such as PI3K/AKT/ mTOR) and hepatic transcription factors (such as MLXIPL/ChREBP and SREBPs). [12][13][14][15] In this study, we investigated the role of lncRNA H19 in regulating hepatic lipid metabolism. Emerging evidence suggests that non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), may play an important role in liver metabolism and metabolic diseases.…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes

Wang

Cao

Shu

et al. 2019

J Cellular Molecular Medi

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Liver plays an essential role in regulating lipid metabolism, and chronically disturbed hepatic metabolism may cause obesity and metabolic syndrome, which may lead to non-alcoholic fatty liver disease (NAFLD). Increasing evidence indicates long noncoding RNAs (lncRNAs) play an important role in energy metabolism. Here, we investigated the role of lncRNA H19 in hepatic lipid metabolism and its potential association with NAFLD. We found that H19 was up-regulated in oleic acid-induced steatosis and during the development of high-fat diet (HFD)-induced NAFLD. Exogenous overexpression of H19 in hepatocytes induced lipid accumulation and up-regulated the expression of numerous genes involved in lipid synthesis, storage and breakdown, while silencing endogenous H19 led to a decreased lipid accumulation in hepatocytes. Mechanistically, H19 was shown to promote hepatic steatosis by up-regulating lipogenic transcription factor MLXIPL. Silencing Mlxipl diminished H19-induced lipid accumulation in hepatocytes. Furthermore, H19-induced lipid accumulation was effectively inhibited by PI3K/mTOR inhibitor PF-04691502. Accordingly, H19 overexpression in hepatocytes up-regulated most components of the mTORC1 signalling axis, which were inhibited by silencing endogenous H19. In vivo hepatocyte implantation studies further confirm that H19 promoted hepatic steatosis by up-regulating both mTORC1 signalling axis and MLXIPL transcriptional network. Collectively, these

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Section: Introductionmentioning

confidence: 99%

Long non‐coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes

Wang

Cao

Shu

et al. 2019

J Cellular Molecular Medi

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“…Our understanding of the central dogma of the biology is that the information from the DNA is transcribed into the RNA and then are translated to proteins though, recent evidence shown that our genome consists of more ncRNAs than the protein-coding RNAs, and these ncRNAs are functional (Bertone et al, 2004;Djebali et al, 2012). These observations open up the new paradigm in understanding gene expression and regulation, particularly the multiple and diverse layers of molecular management of a single gene (Cipriano and Ballarino, 2018;Sulaiman et al, 2019). To date, various classes of the ncRNAs have been discovered.…”

Section: Noncoding Rnas (Ncrnas)mentioning

confidence: 99%

Interactions Among Non-Coding RNAs in Diabetic Nephropathy

et al. 2020

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Diabetic Nephropathy (DN) is the most common cause of End-stage renal disease (ESRD). Although various treatments and diagnosis applications are available, DN remains a clinical and economic burden. Recent findings showed that noncoding RNAs (ncRNAs) play an important role in DN progression, potentially can be used as biomarkers and therapeutic targets. NcRNAs refers to the RNA species that do not encode for any protein, and the most known ncRNAs are the microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Dysregulation of these ncRNAs was reported before in DN patients and animal models of DN. Importantly, there are some interactions between these ncRNAs to regulate the crucial steps in DN progression. Here, we aimed to discuss the reported ncRNAs in DN and their interactions with critical genes in DN progression. Elucidating these ncRNAs regulatory network will allow for a better understanding of the molecular mechanisms in DN and how they can act as new biomarkers for DN and also as the potential targets for treatment.

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“…The importance of long noncoding RNA (lncRNA) has become a focus of hepatic lipid metabolism and fatty liver [21,22]. A large number of lncRNAs have been identified in the livers of NAFLD patients [23].…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Detection of Key Genes and Epigenetic Markers for Chicken Fatty Liver

Tan

Liu

Xing

et al. 2020

IJMS

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Chickens are one of the most important sources of meat worldwide, and the occurrence of fatty liver syndrome (FLS) is closely related to production efficiency. However, the potential mechanism of FLS remains poorly understood. An integrated analysis of data from whole-genome bisulfite sequencing and long noncoding RNA (lncRNA) sequencing was conducted. A total of 1177 differentially expressed genes (DEGs) and 1442 differentially methylated genes (DMGs) were found. There were 72% of 83 lipid- and glucose-related genes upregulated; 81% of 150 immune-related genes were downregulated in fatty livers. Part of those genes was within differentially methylated regions (DMRs). Besides, sixty-seven lncRNAs were identified differentially expressed and divided into 13 clusters based on their expression pattern. Some lipid- and glucose-related lncRNAs (e.g., LNC_006756, LNC_012355, and LNC_005024) and immune-related lncRNAs (e.g., LNC_010111, LNC_010862, and LNC_001272) were found through a co-expression network and functional annotation. From the expression and epigenetic profiles, 23 target genes (e.g., HAO1, ABCD3, and BLMH) were found to be hub genes that were regulated by both methylation and lncRNAs. We have provided comprehensive epigenetic and transcriptomic profiles on FLS in chicken, and the identification of key genes and epigenetic markers will expand our understanding of the molecular mechanism of chicken FLS.

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Regulatory Non-coding RNAs Network in Non-alcoholic Fatty Liver Disease

Cited by 52 publications

References 141 publications

Long non‐coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes

Long non‐coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes

Interactions Among Non-Coding RNAs in Diabetic Nephropathy

Genome-Wide Detection of Key Genes and Epigenetic Markers for Chicken Fatty Liver

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