Regulatory role of N6-methyladenosine in intramuscular fat deposition in chicken

Zhang, Tong; Yu, Baojun; Cai, Zhen; Jiang, Qingjun; Xi, Fu; Zhao, Wei; Wang, Haorui; Gu, Yan; Zhang, Juan

doi:10.1016/j.psj.2023.102972

Cited by 4 publications

(1 citation statement)

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“…Chemically regulates the expression of CTNNBI, thereby promoting adipogenesis [82]. conducted RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing (RNA-seq) analyses on breast and leg tissues from 180-day-old Jingyuan chickens, revealing differentially methylated genes involved in the regulation of muscle lipid anabolism, including enoyl-CoA hydratase 1 (ECH1), branched chain amino acid transaminase 1 (BCAT1), and cytochrome P450 family 1 subfamily B member 1 (CYP1B1) [83]. Yu et al (2023) demonstrated that the m 6 A-induced ferroptosis pathway in breast muscle tissue was a novel target for regulating IMF metabolism and validated the finding that chicken Leiomodin 2 (LMOD2) and its multiple m 6 A negative regulatory DMGs are potential regulators of differential IMF deposition in muscle [84].…”

Section: Epigenetic Modificators Controlling Imf Depositionmentioning

confidence: 99%

Genomic Insights into Molecular Regulation Mechanisms of Intramuscular Fat Deposition in Chicken

Cao,

Xing,

Guan

et al. 2023

Genes

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Intramuscular fat (IMF) plays an important role in the tenderness, water-holding capacity, and flavor of chicken meat, which directly affect meat quality. In recent years, regulatory mechanisms underlying IMF deposition and the development of effective molecular markers have been hot topics in poultry genetic breeding. Therefore, this review focuses on the current understanding of regulatory mechanisms underlying IMF deposition in chickens, which were identified by multiple genomic approaches, including genome-wide association studies, whole transcriptome sequencing, proteome sequencing, single-cell RNA sequencing (scRNA-seq), high-throughput chromosome conformation capture (HiC), DNA methylation sequencing, and m6A methylation sequencing. This review comprehensively and systematically describes genetic and epigenetic factors associated with IMF deposition, which provides a fundamental resource for biomarkers of IMF deposition and provides promising applications for genetic improvement of meat quality in chicken.

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