2007
DOI: 10.1099/mic.0.29239-0
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Regulatory role of RsgI in sigI expression in Bacillus subtilis

Abstract: The sigma gene, sigI, of Bacillus subtilis belongs to the group IV heat-shock response genes and has many orthologues in the bacterial phylum Firmicutes. The B. subtilis sigI gene is considered to constitute an operon with rsgI (regulation of sigI, formerly ykrI). As little is known about either the structure and function of the sigI-rsgI operon or the SigI regulons, the role of RsgI in heat-inducible transcription of the sigI-rsgI operon was investigated, using Northern analysis and a heat-stable b-galactosid… Show more

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Cited by 31 publications
(60 citation statements)
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“…Transcription of the sigI gene is induced by high temperature, and its gene product is a 70 -type sigma factor involved in the heat shock response (3,64). Because upregulation of I expression, either by deletion of the anti-sigma factor RsgI or by overexpression of sigI, was able to suppress the Mg 2ϩ dependence of the mbl mutant, we predicted that upregulation of I by heat stress should also suppress the ⌬mbl phenotype.…”
Section: Resultsmentioning
confidence: 99%
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“…Transcription of the sigI gene is induced by high temperature, and its gene product is a 70 -type sigma factor involved in the heat shock response (3,64). Because upregulation of I expression, either by deletion of the anti-sigma factor RsgI or by overexpression of sigI, was able to suppress the Mg 2ϩ dependence of the mbl mutant, we predicted that upregulation of I by heat stress should also suppress the ⌬mbl phenotype.…”
Section: Resultsmentioning
confidence: 99%
“…In two of the ten selected suppressor strains, the transposon was found to have inserted independently into the rsgI gene (previously ykrI), encoding the anti-sigma factor for I (3). Three independent insertions were in yflE, encoding a homologue of the lipoteichoic acid synthase LtaS from S. aureus (24; K. Schirner et al, unpublished data).…”
Section: Resultsmentioning
confidence: 99%
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“…The sigma gene sigI of B. subtilis belongs to the group IV heat-shock response genes and seems to be negatively regulated by anti-SigI factor RsgI as are ECF sigmas in B. subtilis (Asai et al, 2007). In the cells lacking GL, some ECF sigmas (SigM, SigV, and SigX; data not shown) and SigI were activated (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…8). Asai et al (2007) and Tseng and Shaw (2008) have examined the SigI regulon; however, the mechanism of SigI activation is still unclear. Our results indicate that SigI responds to the lack of GL, and is activated by an unknown mechanism.…”
Section: Discussionmentioning
confidence: 99%