Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice

Saito, Tomoko; Sasaki, Yasushi; Itoh, Michiya; Nakashima, Akitoshi; Ishii, Naoto; Sugamura, Kazuo; Saito, Shigeru

doi:10.1016/j.jri.2010.02.006

Cited by 273 publications

(245 citation statements)

References 39 publications

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“…Both depletion and adoptive transfer of Tregs modulate the rate of resorption. Depletion of Tregs results in an increased rate of resorption and failure in implantation in early pregnancy, as reported by Shima et al [57] In another study, Yin et al provide similar evidence of modulation of fetal resorption by Tregs in early pregnancy by adoptive transfer of Tregs expanded in vitro. [58] An increase in the Treg population in the periphery during allogeneic pregnancy [31,32,59] and recognition and tolerance to paternal alloantigens are reported in mice model of allogeneic pregnancy.…”

Section: Tregs and Tolerance At The Fmi And In The Peripherysupporting

confidence: 70%

Role of PD1/PDL1 pathway, and TH17 and treg cells in maternal tolerance to the fetus

Tripathi

Guleria

2015

Biomed J

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Section: Tregs and Tolerance At The Fmi And In The Peripherysupporting

confidence: 70%

Role of PD1/PDL1 pathway, and TH17 and treg cells in maternal tolerance to the fetus

Tripathi

Guleria

2015

Biomed J

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“…Increased numbers of Treg are found in pregnant mice and humans (47). Depletion of Treg induces resorption of the embryos in allogeneic matings in mice (46,48), whereas women with repeated spontaneous abortion show a decreased numbers of Treg (49,50). Tregs are identified as CD4 + CD25 + T cells expressing the signature transcription factor FOXP3 (51).…”

Section: Discussionmentioning

confidence: 99%

Semen Promotes the Differentiation of Tolerogenic Dendritic Cells

Lenicov

Rodrígues

Sabatté

et al. 2012

The Journal of Immunology

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Seminal plasma is not just a carrier for spermatozoa. It contains high concentrations of cytokines, chemokines, and other biological compounds that are able to exert potent effects on the immune system of the receptive partner. Previous studies have shown that semen induces an acute inflammatory response at the female genital mucosa after coitus. Moreover, it induces regulatory mechanisms that allow the fetus (a semiallograft) to grow and develop in the uterus. The mechanisms underlying these regulatory mechanisms, however, are poorly understood. In this study, we show that seminal plasma redirects the differentiation of human dendritic cells (DCs) toward a regulatory profile. DCs differentiated from human monocytes in the presence of high dilutions of seminal plasma did not express CD1a but showed high levels of CD14. They were unable to develop a fully mature phenotype in response to LPS, TNF-α, CD40L, Pam2CSK4 (TLR2/6 agonist), or Pam3CSK4 (TLR1/2 agonist). Upon activation, they produced low amounts of the inflammatory cytokines IL-12p70, IL-1β, TNF-α, and IL-6, but expressed a high ability to produce IL-10 and TGF-β. Inhibition of the PG receptors E-prostanoid receptors 2 and 4 prevented the tolerogenic effect induced by seminal plasma on the phenotype and function of DCs, suggesting that E-series PGs play a major role. By promoting a tolerogenic profile in DCs, seminal plasma might favor fertility, but might also compromise the capacity of the receptive partner to mount an effective immune response against sexually transmitted pathogens.

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“…We have injected various amounts of anti-CD25 monoclonal antibody on 4.5 and 7.5 days after mating and found that an over 60% decrease of Treg cells could induce abortion in allogeneic pregnancy. 48 CBA ⁄ J female mice mated with DBA ⁄ 2J male mice is a good model for abortion. Interestingly, Zenclussens et al 16 reported fewer Treg cells associated with elevated Th1-type immunity in CBA ⁄ J · DBA ⁄ 2J mating.…”

Section: Th1/th2/th17 and Treg Paradigms In Normal Pregnancymentioning

confidence: 99%

REVIEW ARTICLE: Th1/Th2/Th17 and Regulatory T‐Cell Paradigm in Pregnancy

Saito

Nakashima

Saito

et al. 2010

American J Rep Immunol

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Citation Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T‐cell paradigm in pregnancy. Am J Reprod Immunol 2010T‐helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)‐β and interleukin (IL)‐10 or by cell‐to‐cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.

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Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice

Cited by 273 publications

References 39 publications

Role of PD1/PDL1 pathway, and TH17 and treg cells in maternal tolerance to the fetus

Role of PD1/PDL1 pathway, and TH17 and treg cells in maternal tolerance to the fetus

Semen Promotes the Differentiation of Tolerogenic Dendritic Cells

REVIEW ARTICLE: Th1/Th2/Th17 and Regulatory T‐Cell Paradigm in Pregnancy

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