2015
DOI: 10.4103/2319-4170.143511
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Role of PD1/PDL1 pathway, and TH17 and treg cells in maternal tolerance to the fetus

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Cited by 44 publications
(13 citation statements)
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“…Engagement of PD-L1 with its receptor, PD-1 on T cells leads to the promotion of Treg development and function and down-regulation of T-cell responses. The interactions between PD-1 and PD-L1 participate in the maintenance of pregnancy partly by regulating Treg- and Th17-immunity 29 30 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Engagement of PD-L1 with its receptor, PD-1 on T cells leads to the promotion of Treg development and function and down-regulation of T-cell responses. The interactions between PD-1 and PD-L1 participate in the maintenance of pregnancy partly by regulating Treg- and Th17-immunity 29 30 .…”
Section: Discussionmentioning
confidence: 99%
“…Apart from autoimmune disorders, this pathway has been proven to be involved in the establishment of maternal-fetal tolerance 26 27 , since PD-L1 blockade results in the reduction in litter size, number and increase in embryo resorption of mice, and the failure of fetal–maternal tolerance with Treg deficiency and hyperactivity of Th17 cells 28 . Therefore, the altered PD-1/PD-L1 pathway may be associated with the Treg/Th17 imbalance in human pregnancy 29 30 . The PD-1/PD-L1 pathway is considered a particularly attractive therapeutic target in autoimmune diseases, because the development of PD-1 agonists could deliver the necessary ‘one-two punch’ to protect against self-reactivity: (I) augmenting iTreg function and (II) concomitantly suppressing the expansion and functions of activated effector T cells 20 .…”
mentioning
confidence: 99%
“…Our working hypothesis is that NPI and SELTA through engagement of TLR2 increase PDL1/2 expression. The increased ligands serve to directly repress activated CD4+ve T-cells, including Th17 cells, via PD1, while also inducing IL10 expression [43]. IL10 can then act to reverse EAP-induced increases in IL17 via either direct expansion or increased activity of T-regs.…”
Section: Discussionmentioning
confidence: 99%
“…PD-1 is also able to directly promote interleukin-10 (IL-10) secretion by T cells ( 23 ) and inhibit the maturation of DCs ( 24 ). PD-L1/PD-1 interaction shows a critical role also for the establishment of fetus tolerance ( 25 , 26 ).…”
Section: Introductionmentioning
confidence: 99%