Squamous cell carcinoma is one of the most common malignant lesions in the oral cavity. This lesion can present itself on the tongue and may be treated by a combination of surgery, radiation therapy, and chemotherapy. When present on the lateral border of the tongue hemiglossectomy of the affected side is required. This results in altered functional movements, posture and adaptation of the tongue. This condition can be aggravated by deficient alveolar ridge, suturing of the flap across the crest of the ridge, high tissue attachments, altered floor of the mouth and loss of buccal and lingual sulcus. Prosthetic management in such cases includes an unconventional procedure to treat the patient. This article presents a clinical report on the rehabilitation of a partially edentulous patient with right sided hemiglossectomy with maxillary cast partial denture and mandibular flexible denture.