Rehabilitation for Parkinson's disease: a systematic review of available evidence

Abstract

Findings may reflect publication bias, but suggest interventions can affect patients' lives for the better in a variety of ways. It is difficult to interpret the clinical importance of statistically significant improvements reported in most studies. There is a need for methodologically more robust research with meaningful follow-up periods, designed in a manner that separates specific and nonspecific effects. Cost-effectiveness evidence is required to provide clear guidance on service extensions.

Rehabilitation Interventions for the Management of Multiple Sclerosis Relapse

“…13,30,31 Significant intervention effects on disability or impairment among people with MS reported in this review are consistent with research in other populations. However, an immediate apparent intervention effect after a relapse may simply be a result of natural recovery rather than rehabilitation.…”

Internet-based physical assessment of people with Parkinson disease is accurate and reliable: A pilot study

“…Evidence exists for the positive effects of physiotherapy intervention for people with PD. A systematic review of 25 physiotherapy intervention studies by Gage and Storey found that physiotherapy treatment resulted in improvements across a host of outcome measures, including mobility, functional status, motor performance, gait, and activities of daily living [2]. This was further demonstrated in a review by Allen et al [3].…”

Driving GDNF expression: The green and the red traffic lights

“…Complete behavioural and neurochemical sparing is achieved when exercise of the affected limb begins immediately after the lesion, whereas no sparing occurs when exercise begins 7 days after 6-OHDA lesion (Tillerson et al, 2001). Furthermore, the data from animal models might parallel observations of beneficial effects of exercise on motor and non-motor symptoms in PD patients (Lehman et al, 2005; reviewed by Gage and Storey, 2004;Logroscino et al, 2006). In addition, epidemiological studies show a negative correlation between the regular practice of exercise and the prevalence of PD in humans, at least in males (Tsai et al, 2002;Chen et al, 2005a).…”