Reinke's oedema: a premalignant condition?

Nielsen, V. Moesgaard; Højslet, P. E.; Palvio, Doris H. B.

doi:10.1017/s0022215100100751

Cited by 23 publications

(7 citation statements)

References 3 publications

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“…Some investigators speculated that RE may delay or even inhibit malignant transformation, and the relatively low risk of dysplasia is an important factor. Moesgaard Nielsen et al [31] reported 120 patients treated for RE and found 25% patients with mild dysplasia, 75% without dysplasia and 1 case of invasive cancer during the follow-up examination. They proposed that the risk of malignancy may be connected more with smoking than with RE itself.…”

Section: Discussionmentioning

confidence: 99%

The Protective Role of Autophagy in Human Vocal Fold Fibroblasts under Cigarette Smoke Extract Exposure: A New Insight into the Study of Reinke's Edema

Wang

Fang²,

Peterson³

et al. 2015

ORL

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Background/Aims: Reinke's edema (RE), one of the most common benign lesions of the human vocal folds, has been associated with cigarette smoking. We have observed an abundant number of autophagosomes in the cytoplasm of fibroblasts in the lamina propria of human vocal folds under transmission electron microscopy in RE tissue. Thus, we conducted a study about autophagy induced by cigarette smoke extract (CSE) exposure in cultured human vocal fold fibroblasts (hVFFs). Methods: Sampled tissues were cultured and exposed to varying levels of CSE. Immunochemistry staining and Western blot analyses were then performed on the cultures. Results: We demonstrated that CSE significantly promoted intracellular reactive oxygen species accumulation and reduced the viability of hVFFs in a concentration-dependent manner. Both immunocytochemistry and Western blot analysis showed increased expression of the autophagy marker type II-membrane-associated light chain 3 in fibroblasts following 24 h of CSE exposure, indicating the upregulation of autophagy activity. Furthermore, the results demonstrate that the induction of autophagy played a protective role in hVFFs exposed to CSE. Conclusion: Autophagy can be induced by CSE in hVFFs, and it is a protective response of hVFFs to the exposure of CSE. This study provides a new insight into the process involved in the development of RE.

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Section: Discussionmentioning

confidence: 99%

The Protective Role of Autophagy in Human Vocal Fold Fibroblasts under Cigarette Smoke Extract Exposure: A New Insight into the Study of Reinke's Edema

Wang

Fang²,

Peterson³

et al. 2015

ORL

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“…In a recently published study, we presented the histological findings and those from electron scanning and transmission microscopies of Reinke's edema, reporting on different levels of epithelial dysplasia and one case of in situ carcinoma 13 . This concern about possible pre-neoplastic alterations associated with Reinke's edema had already been reported by some authors [14][15] . Marcotullio et al 15 studied 125 cases of Reinke's edema and found 52 cases classified as grade 0 epithelial alterations, 64 grade I, 6 grade II and 3 grade III, among which there was one case of microinvasive carcinoma.…”

Section: Discussionmentioning

confidence: 66%

Edema de Reinke: estudo da imunoexpressão da fibronectina, da laminina e do colágeno IV em 60 casos por meio de técnicas imunoistoquímicas

Martins¹,

Domingues²,

Fabro³

et al. 2009

Braz. j. otorhinolaryngol. (Impr.)

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Rei nke's edema is chronic laryngeal disease in which the superficial layer of the lamina propria is expanded by thick mucus, giving it a gelatin aspect. The disease is directly related to smoking and more frequent in women, who end up having a lower tone of voice. Its histological characteristics cannot always distinguish it from other benign lesions of the larynx for which additional histological techniques are necessary. Aim: to study the immunoexpression of fibronectin, collagen IV and laminin in Reinke's edema by immunohistochemical technique. Prospective study. Materials and methods: histological blocks of 60 cases of surgical Reinke's edema were saved, submitted to new cross-sections and to immunohistochemical reactions for fibronectin, laminin and collagen IV by the Avidin-Biotin-Peroxidase method. Fragments of five normal vocal folds were used as control, removed during autopsy. All patients were chronic smokers and adults-50 women and 10 men. Results: the immunoexpression of fibronectin, collagen IV and laminin was more important in the endothelium of blood vessels (68.33%, 76.66%, 73.33%, respectively) and less relevant in the basement membrane (25.0%, 5.0% and 3.3%, respectively). Conclusions: the immunoexpression of fibronectin, laminin and of collagen IV in the basal membrane of Reinke's edema was not relevant, with a predominance of these antibodies in the endothelium of blood vessels.

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“…45 This is congruous with other reports in the literature. 20,33,34,40,46 Non-ablative in-office laser management of Reinke's edema was first described using the pulse dye laser, followed by the KTP and more recently by the CO 2 laser. In these methods no immediate size reduction is achieved.…”

Section: Microdebridermentioning

confidence: 99%

Reinke's edema management and voice outcomes

Dewan

Chhetri

Hoffman

2022

Laryngoscope Investig Oto

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Objectives Reinke's edema is a chronic disease of the respiratory tract that occurs in adults with a history of chronic smoke exposure. Also known as polypoid corditis, polypoid laryngitis, and polypoid degeneration of the vocal fold, it is strongly associated with smoking, frequently with vocal misuse/abuse, and occasionally with laryngopharyngeal reflux. Reinke's edema remains a cause of chronic dysphonia that is difficult to manage. This review provides perspectives on current and future management of Reinke's edema. Results Reinke's edema impacts <1% of the population. The excessive mass is seen in polypoid degeneration results in a loss of pitch control and a rough voice. Women are more likely to present for treatment as the characteristic lowering of vocal pitch is more noticeable in women than men. Multiple grading systems have been proposed within the literature. The current standard of care is surgical excision, after smoking cessation. The microflap technique remains the approach of choice for bulky lesions. Surgical management of Reinke's edema has evolved with the introduction of various lasers into otolaryngologic practice; some which can now be used in the office setting. While many management approaches have been described within the literature, there is a little direct comparison and no obvious superior method of Reinke's edema management. Conclusion To date, the biology of Reinke's edema is not well understood. Additional research is needed further elucidate the role of uncontrolled reflux in the development and recurrence of Reinke's edema.

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Reinke's oedema: a premalignant condition?

Cited by 23 publications

References 3 publications

The Protective Role of Autophagy in Human Vocal Fold Fibroblasts under Cigarette Smoke Extract Exposure: A New Insight into the Study of Reinke's Edema

The Protective Role of Autophagy in Human Vocal Fold Fibroblasts under Cigarette Smoke Extract Exposure: A New Insight into the Study of Reinke's Edema

Edema de Reinke: estudo da imunoexpressão da fibronectina, da laminina e do colágeno IV em 60 casos por meio de técnicas imunoistoquímicas

Reinke's edema management and voice outcomes

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