Reinnervation and renin release after unilateral renal denervation in the dog.

Nomura, Gakushi; Kurosaki, Masao; Takabatake, Toshikazu; Y, Kibe; Takeuchi, Jugoro

doi:10.1152/jappl.1972.33.5.649

Cited by 34 publications

(19 citation statements)

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“…Our experiment was done under mild water load before experiment, which was also used in the previous experiment. The denervation diuresis observed in that experiment was also mild, but statisti cally significant [14]. On the contrary, most other investigators used saline loading [3,4,6,7].…”

Section: Discussionmentioning

confidence: 70%

“…We have previously reported that the denervation natriuresis and diuresis occurred without associated changes in glomerular filtration rate or renal plasma flow in the chronically denervated dog [14], In the present study the acute effect of denervation on renal function and intrarenal blood flow was studied. The results were consistent with the data of Blake and Jurf [3], Bonjour et al [4], and BencsAth and TakAcs [6], i.e.…”

Section: Discussionmentioning

confidence: 76%

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Distribution of Intrarenal Blood Flow after Renal Denervation in the Dog

Nomura¹,

Y²,

Arai³

et al. 1976

Nephron

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The effect of acute denervation of the kidney on renal sodium and water excretion, and hemodynamics including intrarenal blood flow, was studied in anesthetized dogs. The intrarenal blood flow was measured by the radioactive microsphere method. In all experiments denervation natriuresis and diuresis were observed without significant change in glomerular filtration rate, renal blood flow and distribution of intrarenal blood flow. There was, however, an associated increase in potassium excretion. We suggest that denervation natriuresis and diuresis may be caused by the elimination of a direct nervous control of sodium and water reabsorption.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 76%

Distribution of Intrarenal Blood Flow after Renal Denervation in the Dog

Nomura¹,

Y²,

Arai³

et al. 1976

Nephron

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“…The ability of nerves to sprout and attempt to regenerate in response to injury has been previously described. [21][22][23] This study strongly suggests that renal sympathetic nerves attempt to regenerate but without apparent functional reconnection based on persistent NE level suppression. 14,[24][25][26] The high degree of distal nerve atrophy observed at 7 and 30 days in this study reported at chronic time points in other large animal experiments where RF ablation of renal nerves was performed.…”

Section: Discussionmentioning

confidence: 73%

Sub-acute Safety and Efficacy Evaluation of Single versus Double Treatment Cycles of a Monopolar Radiofrequency Catheter-Based Renal Nerve Ablation and its Chronic Evolution in a Large Animal Model

Hubbard¹,

Sakaoka²,

Brants³

et al. 2016

J.ATAMIS

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Aims:We aimed to evaluate the transcatheter renal denervation(RDN) effects delivered by a mono-electrode catheter in a large animal model including safety implications of delivery of one cycle versus two cycles of ablations.Methods and Results:18 animals underwent bilateral RDN; 4 untreated naïve swine were enrolled as controls for norepinephrine levels(NE) only. Animals recieved 120-second (follow up-7,30 and 90 days) or 240-second cycles ablations (follow up-7 days). Norepinephrine evaluation, histology and immunohistochemistry evaluation was performed. No luminal obstruction was observed at follow up. A 70% decrease in NE levels (76.68±57.87ng/g) was observed at 7 days, 81% at 30 days(49.05±45.81ng/g), and 51% at 90 days(12.7±73.2 ng/g) compared to naïve controls(254.1±54.1ng/g;p<0.05). Histologically, the thermal effect extended to a complete circumferential involvement with a depth ~8mm. The primary histological feature at 7 days was nerve necrosis and distal atrophy; at 30 days, necrosis was replaced by healing changes of fibrosis. Neuromatous regeneration was apparent at 30 days at RF treated levels. At 90 days these features progressed to become more conspicuous. There were no appreciable differences in depth and circumferential extent of RF injury between one and two cycle treatment groups.Conclusion:RDN performed with a mono-electrode catheter (Iberis) appears to be safe following single or double-cycle RF ablation.NE decrease following RDN was demonstrated at 7, 30, and 90 days compared to naïve controls, suggesting efficient nerve ablation with the device as intended for human use.

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“…One possibility is that reinnervation of the kidney can occur after extended time periods, e.g., 2-3 mo. While evidence suggests regeneration of the adrenergic nerves does occur, there is no evidence of regeneration even after 3 mo in the dog (10). Previously, we have used chronic renal denervation for 4 wk and measured the RBF differences between intact and denervated kidneys (1).…”

Section: Discussionmentioning

confidence: 99%

Is the chronically denervated kidney supersensitive to catecholamines?

Ramchandra

Barrett

Guild

et al. 2002

American Journal of Physiology-Regulatory, Integrative and Comp

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One method for discerning the role of the renal sympathetic nerves in the regulation of renal function has been to chronically denervate one kidney. One concern with this approach is that increased renal responsiveness to plasma levels of norepinephrine may develop over time. This may reduce the apparent magnitude of the effect of the renal nerves or indeed completely mask their effect. In the present experiment, we used the rabbit unilateral denervated kidney model to examine the acute renal blood flow responses to phenylephrine to determine if there were differences between the responses in chronically denervated kidneys compared with either intact or acutely denervated kidneys. In addition, we examined the responses in rabbits that had been made hypertensive using a continuous infusion of ANG II for 7 wk. We found that chronic denervation did not result in increased renal responsiveness to phenylephrine compared with either the intact or acutely denervated kidney, suggesting that differences in renal function between renal nerve-intact and -denervated kidneys observed in previous studies are unlikely to be confounded by supersensitivity. These results suggest that the unilateral denervated kidney model is a valid model to study the role of the renal nerves in the regulation of renal function.

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Reinnervation and renin release after unilateral renal denervation in the dog.

Cited by 34 publications

References 0 publications

Distribution of Intrarenal Blood Flow after Renal Denervation in the Dog

Distribution of Intrarenal Blood Flow after Renal Denervation in the Dog

Sub-acute Safety and Efficacy Evaluation of Single versus Double Treatment Cycles of a Monopolar Radiofrequency Catheter-Based Renal Nerve Ablation and its Chronic Evolution in a Large Animal Model

Is the chronically denervated kidney supersensitive to catecholamines?

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