Reirradiation of Recurrent and Second Primary Cancers of the Head and Neck: a Review of the Contemporary Evidence

Kreinbrink, P.J.; Lewis, Luke; Redmond, Kevin P.; Takiar, Vinita

doi:10.1007/s11864-021-00936-y

Cited by 9 publications

(9 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, the presence of ulceration associated with carotid invasion > 180° is an important risk factor for CBOS 13 , 14 . In recent SBRT-based approaches, CBOS has also been correlated with tumors > 26 cc, carotid invasion ≥ 180°, and doses > 34 Gy in five fractions 22 , 30 . The findings of the present study concur with those of previous studies, as all nine tumors that caused hemorrhage involved the carotid > 180 degrees and larger GTV than non-hemorrhagic tumors.…”

Section: Discussionmentioning

confidence: 99%

“…The findings of the present study concur with those of previous studies, as all nine tumors that caused hemorrhage involved the carotid > 180 degrees and larger GTV than non-hemorrhagic tumors. The Hypofractionated Treatment Effects in the Clinic (HyTEC) group found that a maximum dose to the major vessels of 20–30 Gy in 5 fractions was generally low risk, but risk increased quickly > 30 Gy to a tolerance dose of 45.7 Gy 15 , 22 , 30 . The other factors that reduced the rate of CBOS were alternate day treatment rather than daily treatment, not treating patients with skin invasion, necrosis, or infection, and avoiding postoperative treatment 15 .…”

Section: Discussionmentioning

confidence: 99%

“…nasopharyngeal primary site vs. other sites), histology (i.e. squamous cell carcinoma [SCC] or not), the interval between treatment, tumor or treatment volume, surgical procedure, and prescribed dose [22][23][24] . Lee et al reported frequency of toxicities of grade ≥ 3 was 9.6-26% 20,21 which may be lower than the previous two-or three-dimensional radiotherapy era, however also retains a substantial influence on patients' quality of life.…”

Section: Discussionmentioning

confidence: 99%

“…In other classes, IMRT was associated with improved OS (especially for rT3-4 and prescribed dose ≥ 66 Gy), except when ≥ 35 Gy was administered with SBRT to small tumor volumes ≤ 25 cm . Additionally, primary sites, such as the oral cavity, oropharynx, larynx, and hypopharynx showed poorer prognoses than other sites, not only for the nasopharynx, but also for the nasal sinus, paranasal sinus, parotid, orbit, and thyroid in several studies [22][23][24][25][26][27][28] . Therefore, a major part of our study cohort may belong to the poor prognosis category in the entire head and neck reirradiation series.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study

Yamazaki

Suzuki

Aibe

et al. 2023

Sci Rep

View full text Add to dashboard Cite

This study aimed to examine the efficacy and toxicity of reirradiation in patients with locally recurrent oral, pharyngeal, and laryngeal cancers. We conducted a retrospective, multi-institutional analysis of 129 patients with previously irradiated cancer. The most frequent primary sites were the nasopharynx (43.4%), oral cavity (24.8%), and oropharynx (18.6%). With a median follow-up duration of 10.6 months, the median overall survival was 14.4 months and the 2-year overall survival rate was 40.6%. For each primary site, the 2-year overall survival rates were 32.1%, 34.6%, 30%, 60.8%, and 5.7% for the hypopharynx, oral cavity, larynx, nasopharynx, and oropharynx, respectively. Prognostic factors for overall survival were primary site (nasopharynx versus other sites) and gross tumor volume (GTV) (≤ 25 cm3 versus > 25 cm3). The 2-year local control rate was 41.2%. Twenty-four patients (18.6%) presented with grade ≥ 3 toxicities, including nine with hemorrhages that led to grade 5 toxicities in seven patients. All nine tumors that caused hemorrhage showed tumor encasement of the carotid ≥ 180 degrees and eight of nine tumors had larger GTV > 25 cm3. Reirradiation is a feasible treatment option for small local recurrence of oral, pharyngeal, and laryngeal cancers, with the requirement of a strict eligibility assessment for large tumors with carotid encasement.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study

Yamazaki

Suzuki

Aibe

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In unresectable or medically inoperable cases, definitive rRT with or without concurrent chemotherapy is the appropriate treatment option in carefully selected patients [9,11,13]. rRT can be administered via IMRT, stereotactic body radiation therapy (SBRT) whenever possible, or proton therapy whenever available [9,15,16].…”

Section: Introductionmentioning

confidence: 99%

Re-Irradiation for Recurrent Head and Neck Cancer: Freedom from Cancer Recurrence Rate

Mohamad

Hejleh

Abdelqader

et al. 2023

JCM

View full text Add to dashboard Cite

Salvage re-irradiation (rRT) for patients with locoregionally recurrent head and neck cancer (rHNC) remains challenging. A retrospective analysis was performed on 49 patients who received rRT between 2011 and 2018. The co-primary endpoint of the study was 2-year freedom from cancer recurrence rate (FCRR) and overall survival (OS), and secondary endpoints were 2-year disease-free survival (DFS), local failure (LF), regional failure (RF), distant metastases (DM), and RTOG grade 3 ≥ late toxicities. Adjuvant and definitive rRT were delivered to 22 and 27 patients, respectively. A total of 91% of patients were managed with conventional re-RT and 71% of patients received concurrent chemotherapy. The median follow-up after rRT was 30 months. The 2-year FCRR, OS, DFS, LF, RF, and DM were 64%, 51%, 28%, 32%, 9%, and 39% respectively. MVA showed that poor performance status (PS: 1–2 vs. 0) and age > 52 years were predictive of worse OS. In comparison, poor PS (1–2 vs. 0) and total dose of rRT < 60 Gy were predictive of worse DFS. Late RTOG toxicity of grade 3 ≥ was reported in nine (18.3%) patients. FCRR at 2 years after salvage rRT for rHNC was higher than other traditional endpoints and could be an important endpoint to be included in future rRT studies. rRT for rHNC at our cohort was relatively successful, with a manageable level of late severe toxicity. Replacing this approach in other developing countries is a viable option.

show abstract

Salvage transoral robotic surgery in recurrent oropharyngeal carcinoma: a single-center retrospective study

Ansarin,

Pietrobon,

Tagliabue

et al. 2024

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Reirradiation of Recurrent and Second Primary Cancers of the Head and Neck: a Review of the Contemporary Evidence

Cited by 9 publications

References 49 publications

Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study

Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study

Re-Irradiation for Recurrent Head and Neck Cancer: Freedom from Cancer Recurrence Rate

Salvage transoral robotic surgery in recurrent oropharyngeal carcinoma: a single-center retrospective study

Contact Info

Product

Resources

About