Relação da depressão com os eixos hipotálamo-hipófise-adrenal, hipotálamo-hipófise-tireóide e o estresse precoce

Vilela, Lúcia Helena Moraes

doi:10.11606/t.17.2014.tde-09122014-152101

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…This deficient and scarce consumption activates mechanisms that raise cortisol levels, which increases the degree of stress of these individuals [40]. In addition, exposure to high levels of stress can cause dysfunction of the hypothalamic-pituitary-adrenal axis, which would increase the chance of DS appearing [41]. These two pathways, one pychosocial and the other endocrinometabolic, are indicated for explaining the relationship between DS and FI [27,[38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Food insecurity and depressive symptoms among older adults assisted by the Family Health Strategy in the Northeast region of Brazil

Pereira

Teles

et al. 2023

Rev. Nutr.

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Objective This study aimed to investigate the association between depressive symptoms and food insecurity in households with older adults. Methods This is a cross-sectional, quantitative study conducted with community-dwelling older adults attended to in the Family Health Strategy in a municipality in the Brazilian Northeast. Depressive symptoms were evaluated using the Geriatric Depression Scale and food insecurity was assessed using the Brazilian Food Insecurity Scale. The chi-squared test was applied for a bivariate analysis and binary logistic regression was used to verify the association between depressive symptoms and food insecurity, adjusted for potential confounding variables. The significance level was p<0.05. Results A total of 316 older adults were evaluated, with a mean age of 70.5 (±7.5 years). The prevalence of depressive symptoms was 27.5% and that of food insecurity was 63.3%, with 25.6% of households with older adults experiencing moderate/severe insecurity. In the multivariate analysis, households experiencing mild food insecurity presented 3 times (OR: 3.02; 95% CI: 1.42-6.39) more chance of developing depressive symptoms, while in those experiencing moderate/severe food insecurity the chance was 5 times higher (OR: 5.01; 95% CI: 2.30-10.92). Conclusion An association was found between food insecurity and depressive symptoms in households with older adults of the Family Health Strategy, with more chances for those experiencing moderate/severe food insecurity.

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Section: Discussionmentioning

confidence: 99%

Food insecurity and depressive symptoms among older adults assisted by the Family Health Strategy in the Northeast region of Brazil

Pereira

Teles

et al. 2023

Rev. Nutr.

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“…An adequate response to stress involves the coordinated activity of the autonomic nervous system and the HPA axis, as well as the neural circuits in the hypothalamus, brainstem and prefrontal regions [ 40 ]. The association between MDD and changes in the HPA axis has been described over the years, as well as its involvement in neurogenesis [ 41 ]. The hypothalamus secretes a corticotrophin releasing hormone (CRH) which is transported to the anterior pituitary, where it stimulates adrenocorticotrophic hormone secretion (ACTH).…”

Section: Resiliencementioning

confidence: 99%

“…Studies have shown that in depressed patients, the HPA axis may be affected by hyperactivity or hypoactivity, thus resulting in increased or decreased basal concentrations of hormones. Its activity may also be dysregulated, and this change may occur due to increased concentrations of one of the hormones at different times of the day, and unchanged or decreased levels of others [ 41 , 42 ].…”

Section: Resiliencementioning

confidence: 99%

Resilience Dysregulation in Major Depressive Disorder: Focus on Glutamatergic Imbalance and Microglial Activation

Réus¹,

Moura²,

Silva³

et al. 2018

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Background: Many studies have been shown an important role of glutamatergic system as well microglial activa-tion in the pathophysiology of major depressive disorder (MDD). In humans most resistant to the development of psychiat-ric disorders, including MDD, are observed a greater degree of resilience resulting from stress. Less resilience is associated with neuroendocrine and neuroinflammatory markers, as well as with glutamatergic system dysregulation. Thus, this review we highlighted findings from literature identifying the function of glutamatergic system, microglial activation and inflamma-tion in resilience.Methods: We conducted a review of computerized databases from 1970 to 2017.Results: There is an association between microglial activation and glutamatergic system activation with stress vulnerability and resilience.Conclusions: Glutamate neurotransmission, including neurotransmitter synthesis, signalling, and glutamate receptor func-tions and expression all seem to be involved with both stress vulnerability and resilience. Moreover, inflammation and mi-croglial activation mediate individual differences in resilience and the risk of stress-induced MDD.

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“…Ademais, o estresse pode provocar um mau funcionamento do eixo hipotálamo-hipófise-tireoide, pois, o CRH apresenta um importante papel na inibição da secreção de hormônios, dentre os quais o hormônio liberador de tireotropina (TRH) e o hormônio tireoestimulante (TSH), diminuindo as funções da tireoide (TSIGOS;CHROUSOS, 2002;VILELA, 2014). O hormônio TSH atua diretamente na tireoide para estimular a produção dos hormônios triiodotironina (T3) e tiroxina (T4).…”

Section: -Considerações Finaisunclassified

Anatomofisiologia Do Estresse E O Processo De Adoecimento

Rocha

Silva

Matos

et al. 2018

Rev. Cient. Fac. Med Campos

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A organização produtiva contemporânea tem imposto aos cidadãos um estilo de vida competitivo, com ameaça de desemprego, longas jornadas de trabalho, necessidade de consumir, além de outras dificuldades. Durante eventos estressantes ocorre uma resposta do eixo hipotálamo-hipófise-adrenal que secreta o hormônio cortisol. Dependendo da duração e intensidade do estressor, o nível elevado de cortisol pode ocasionar patologias. O presente estudo buscou compreender as bases anatômicas e fisiológicas do processo de adoecimento causado pelo estresse crônico. Dentre as patologias mais estudadas causadas pelo hipercortisolismo estão a hipertensão arterial, aumento da glicose sanguínea, fraqueza muscular, estrias, osteoporose, obesidade, degeneração do encéfalo e a redução da imunidade. É importante salientar que as pessoas emitem respostas diferentes ao estresse, de forma que os sinais e sintomas não serão iguais entre os acometidos. Por fim, toda iniciativa pública ou privada que estabeleça a estabilidade social, econômica e emocional pode suprimir as patologias associadas ao estresse.

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Relação da depressão com os eixos hipotálamo-hipófise-adrenal, hipotálamo-hipófise-tireóide e o estresse precoce

Cited by 4 publications

References 4 publications

Food insecurity and depressive symptoms among older adults assisted by the Family Health Strategy in the Northeast region of Brazil

Food insecurity and depressive symptoms among older adults assisted by the Family Health Strategy in the Northeast region of Brazil

Resilience Dysregulation in Major Depressive Disorder: Focus on Glutamatergic Imbalance and Microglial Activation

Anatomofisiologia Do Estresse E O Processo De Adoecimento

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