Relación entre colesterol y fibrinógeno en dos poblaciones de distinta localización geográfica de Cataluña

Cristobal, Juan José Rodríguez; Alonso-Villaverde, Carlos; Llardén, N Tibau; Babot, O Juan; Corrales, Alejandro; Sendra, Esther Peña

doi:10.1157/13064313

Cited by 2 publications

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“…Los niveles altos de fibrinógeno plasmático se han relacionado con un aumento de la morbimortalidad cardiovascular3, 4, 5 y con complicaciones trombóticas 6 . El fibrinógeno plasmático está también considerado como un marcador de ateromatosis subclínica7, 8 y previamente ya se ha mostrado una interdependencia entre el colesterol plasmático total y el fibrinógeno plasmático 9 .…”

Section: Introductionunclassified

Efectos a largo plazo de una intervención intensiva sobre cambios en los estilos de vida en pacientes con hiperfibrinogenemia y riesgo cardiovascular moderado-alto

et al. 2018

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Section: Introductionunclassified

Efectos a largo plazo de una intervención intensiva sobre cambios en los estilos de vida en pacientes con hiperfibrinogenemia y riesgo cardiovascular moderado-alto

et al. 2018

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“…The study published by Gil et al [8], described an intervention study done in a primary care setting, in patients with an average age of 72.6 years and with several CVRF; the prevalence of hyperfibrinogenemia was found to be 26.5%. Other studies in younger patients with an average age of 57 and clinical manifestations of cardiovascular disease, have found a prevalence of 60% [9,10]. In different epidemiological studies, such as the Yano et al [11], an increase in cardiovascular morbidity and mortality has been shown in patients with fibrinogen levels above 300 mg/dl.…”

Section: Introductionmentioning

confidence: 99%

Randomised clinical trial of an intensive intervention in the primary care setting of patients with high plasma fibrinogen in the primary prevention of cardiovascular disease

Cristobal¹,

Alonso-Villaverde

Mercadé

et al. 2012

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BackgroundWe have studied the possible effects of an intensive lifestyle change program on plasma fibrinogen levels, in patients with no cardiovascular disease, with elevated levels of fibrinogen, normal cholesterol levels, and a moderate estimated risk of coronary heart disease (CHD) and we have also analysed whether the effect on fibrinogen is independent of the effect on lipids.ResultsThis clinical trial was controlled, unblinded and randomized, with parallel groups, done in 13 Basic Health Areas (BHA) in l'Hospitalet de Llobregat (Barcelona) and Barcelona city. The study included 436 patients, aged between 35 and 75 years, with no cardiovascular disease, elevated levels of fibrinogen (> 300 mg/dl), cholesterol < 250 mg/dl, 218 of whom received a more intensive intervention consisting of advice on lifestyle and treatment. The follow-up frequency of the intervention group was every 2 months. The other 218 patients followed their standard care in the BHAs. Fibrinogen, plasma cholesterol and other clinical biochemistry parameters were assessed.The evaluation of the baseline characteristics of the patients showed that both groups were homogenous. Obesity and hypertension were the most prevalent risk factors. After 24 months of the study, statistically significant changes were seen between the adjusted means of the two groups, for the following parameters: fibrinogen, plasma cholesterol, systolic and diastolic blood pressure and body mass index.ConclusionIntensive intervention to achieve lifestyle changes has shown to be effective in reducing some of the estimated CHD factors. However, the effect of intensive intervention on plasma fibrinogen levels did not correlate with the variations in cholesterol.Trial RegistrationClinicalTrials.gov: NCT01089530

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Relación entre colesterol y fibrinógeno en dos poblaciones de distinta localización geográfica de Cataluña

Cited by 2 publications

References 0 publications

Efectos a largo plazo de una intervención intensiva sobre cambios en los estilos de vida en pacientes con hiperfibrinogenemia y riesgo cardiovascular moderado-alto

Efectos a largo plazo de una intervención intensiva sobre cambios en los estilos de vida en pacientes con hiperfibrinogenemia y riesgo cardiovascular moderado-alto

Randomised clinical trial of an intensive intervention in the primary care setting of patients with high plasma fibrinogen in the primary prevention of cardiovascular disease

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