Relapsing Polychondritis Treated With Dapsone

Martin, John J.

doi:10.1001/archderm.1976.01630330034009

Cited by 59 publications

(11 citation statements)

References 8 publications

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“…In combination with trimethoprim it is a second-line treatment of Pneumocystis carinii in AIDS patients (Lee et al, 1989). The drug is also used in a number of inflammatory conditions, including bullous pemphigoid, relapsing polychondritis, leukocytoclastic vasculitis and rheumatoid arthritis (Grindulis & MacConkey 1984;Martin et al, 1976;Person & Rogers, 1977;Thomson et al, 1973), Dapsone is the drug of choice in the treatment of dermatitis herpetiformis (Zone, 1991) although its use is often limited by its toxicity, which is a consequence almost entirely of oxidative metabolism. In man, much of the dose of dapsone is acetylated to monoacetyl dapsone, which is a reversible process.…”

Section: Introductionmentioning

confidence: 99%

The use of cimetidine to reduce dapsone‐dependent methaemoglobinaemia in dermatitis herpetiformis patients.

Coleman¹,

Rhodes²,

Scott³

et al. 1992

Brit J Clinical Pharma

102

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1. We have attempted to reduce dapsone‐dependent methaemoglobinaemia formation in six dermatitis herpetiformis patients stabilised on dapsone by the co‐administration of cimetidine. 2. In comparison with control, i.e. dapsone alone, methaemoglobinaemia due to dapsone fell by 27.3 +/‐ 6.7% and 26.6 +/‐ 5.6% the first and second weeks after commencement of cimetidine administration. The normally cyanotic appearance of the patient on the highest dose of dapsone (350 mg day‐ 1), underwent marked improvement. 3. There was a significant increase in the trough plasma concentration of dapsone (2.8 +/‐ 0.8 x 10(‐5)% dose ml‐1) at day 21 in the presence of cimetidine compared with control (day 7, 1.9 +/‐ 0.6 x 10(‐5)% dose ml‐1, P less than 0.01). During the period of the study, dapsone‐mediated control of the dermatitis herpetiformis in all six patients was unchanged. 4. Trough plasma concentrations of monoacetyl dapsone were significantly increased (P less than 0.05) at day 21 (1.9 +/‐ 1.0 x 10(‐5)% dose ml‐ 1) compared with day 7 (1.6 +/‐ 0.9 x 10(‐5)% dose ml‐1:control). 5. Over a 12 h period, 20.6 +/‐ 8.9% (day 0) of a dose of dapsone was detectable in urine as dapsone hydroxylamine. Significantly less dapsone hydroxylamine was recovered from urine at day 14 (15.0 +/‐ 8.4) in the presence of cimetidine, compared with day 0 (control: P less than 0.05). 6. The co‐administration of cimetidine may be of value in increasing patient tolerance to dapsone, a widely used, effective, but comparatively toxic drug.

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Section: Introductionmentioning

confidence: 99%

The use of cimetidine to reduce dapsone‐dependent methaemoglobinaemia in dermatitis herpetiformis patients.

Coleman¹,

Rhodes²,

Scott³

et al. 1992

Brit J Clinical Pharma

102

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“…For mild RP, such as the auricular or nasal RP only, the most common therapy has included NSAID, lower dose glucocorticoids, dapsone, colchicine, and combinations of the aforementioned agents. [11][12][13][14] The clinical course of RP is highly variable. There is a high incidence of recurrence.…”

Section: Discussionmentioning

confidence: 99%

Surgical Reconstruction of Auricular Relapsing Polychondritis

Zhou¹,

Yang²,

Liu³

2012

Annals of Plastic Surgery

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Relapsing polychondritis (RP) is a multiple system disease of unknown cause characterized by episodic inflammation of cartilage and potentially progressive degeneration of cartilaginous tissue. Solitary auricular cartilage involvement without any inflammatory symptoms is very uncommon and surgical treatment is rarely recommended. We present a 53-year-old Chinese male patient who had undergone a mass resection on the right ear in December 2008 and 1 year later had developed another mass at the same spot. A mass resection and reconstructive surgery were performed and the pathologic result of the mass was auricular RP. Although RP is rarely seen by plastic surgeons, we should have sufficient information about this disease. This case demonstrates a simple and straight surgical approach to obtain an excellent ear appearance.

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“…Dapsone has been reported to be an alternative treatment as a result of inhibition of lysosomal enzyme activity. 17 For patients requiring long-term steroid therapy, azathioprine, methotrexate, and cyclophosphamide have been used and described as steroid-sparing agents. Aggressive therapy with high-dose intravenous steroids and/or immunosuppressive drugs appear to indicate acute airway obstruction.…”

Section: Discussionmentioning

confidence: 99%

Relapsing Polychondritis With Encephalitis

Yang

Chou²

2004

JCR: Journal of Clinical Rheumatology

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Central nervous system manifestations are rare in patients with relapsing polychondritis. We report a case of encephalitis associated with relapsing polychondritis. The patient presented with bilateral auricular chondritis first and then tracheal chondritis, and encephalitis developed. The symptoms and signs of encephalitis were felt mostly likely to be the result of vasculitis and improved dramatically after pulse corticosteroid therapy. We believe that early recognition of central nervous system involvement in relapsing polychondritis is extremely important. High-dose corticosteroids should be given to suspected cases as early as possible.

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Relapsing Polychondritis Treated With Dapsone

Cited by 59 publications

References 8 publications

The use of cimetidine to reduce dapsone‐dependent methaemoglobinaemia in dermatitis herpetiformis patients.

The use of cimetidine to reduce dapsone‐dependent methaemoglobinaemia in dermatitis herpetiformis patients.

Surgical Reconstruction of Auricular Relapsing Polychondritis

Relapsing Polychondritis With Encephalitis

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