Relating the blood-thinning effect of pentoxifylline to the reduction in the elastic modulus of human red blood cells: an<i>in vivo</i>study

Aifantis, Katerina E.; Shrivastava, S.; Pelidou, Sygkliti-Henrietta; Ngan, A.H.W.; Baloyannis, Stavros

doi:10.1039/c8bm01691g

Cited by 11 publications

(8 citation statements)

References 21 publications

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“…Given that the PTX therapeutic dose is 400 mg twice a day, our preliminary results support the view that PXT consumption may be harmful if administered in manganism-and metal-poisoned patients. We propose that PXT possesses significant blood thinning and vasodilator properties as well as deformability and rheological changes of red blood cells (confirmed by atomic force microscopy nanoindentation experiment) [56,57]. PTX decreases the blood and plasma viscosity and lowers plasma fibrinogen while promoting fibrinolysis; it also improves blood filterability by enhancing the erythrocyte distensibility and lessens neutrophil activation [58].…”

Section: Discussionmentioning

confidence: 86%

Effects of Pentoxifylline in a Rat Model of Manganism: Evaluation of the Possible Toxicity

Tanideh

Farshad

Jamshidzadeh

et al. 2021

Journal of Chemistry

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Objective. Manganese (Mn) has been reported, through dietary and occupational overexposure, to induce neurotoxicity named manganism. Pentoxifylline (PTX) administration attracts much attention considering the beneficial properties of PTX, as an anti-inflammatory and smooth muscle relaxation agent. This in vivo study aims to evaluate the effect of PTX on manganism in rat model. Materials and Methods. Thirty adult male Sprague Dawley rats received MnCl2 (100 mg/kg, i.p. on days 1, 3, and 7) during a week alone or in combination with PTX (300 mg/kg, i.p. every day for 8 consecutive days on manganism rat model). Several locomotor activity indices, as well as biomarkers of oxidative stress, were monitored in the brain tissue of Mn-exposed animals. Results. It was found that PTX supplementation (300 mg/kg, i.p.) deteriorated the Mn-induced locomotor deficit. This drug also increased the Mn brain accumulation as well as reactive oxygen species (ROS) and lipid peroxidation products in the manganism rat model. Moreover, the levels of total antioxidant capacity (TAC) and glutathione (GSH) were shown to be reduced significantly compared to the control group. Conclusion. The results of this study revealed that PTX at a high dose (300 mg/kg) might increase manganism complications. PTX lowers the blood viscosity, improves the tissue perfusion, and increases the Mn levels in the brain.

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Section: Discussionmentioning

confidence: 86%

Effects of Pentoxifylline in a Rat Model of Manganism: Evaluation of the Possible Toxicity

Tanideh

Farshad

Jamshidzadeh

et al. 2021

Journal of Chemistry

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“…Caffeine was demonstrated to have a dose-dependent action with benefit at low to moderate doses in some human studies, whilst high-dose led to detrimental effects (Levin et al, 1981;Moussa, 1983;Jiang et al, 1984). Pentoxifylline (PTX), a potent vasodilating agent recommended for the treatment of leg pain caused by chronic occlusive arterial disease of the limbs, was studied as an artificial sperm movement enhancer (Słoczyńska et al, 2013;Aifantis et al, 2019). Its effect on sperm motility was confirmed in several in vivo studies with significantly increased sperm motility in men with oligoasthenoteratozoospermia (OAT) or in vitro studies during a vitrification program without adverse effects on sperm DNA or chromatin integrity (Stanic et al, 2002;Moslemi Mehni et al, 2014;Nabi et al, 2017).…”

Section: Non-selective Pde Inhibitorsmentioning

confidence: 99%

Respiratory Cilia as a Therapeutic Target of Phosphodiesterase Inhibitors

2020

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Mucociliary clearance is an essential airway defense mechanism dependent predominantly on the proper ciliary function and mucus rheology. The crucial role of cilia is evident in`a variety of respiratory diseases, as the ciliary dysfunction is associated with a progressive decline in lung function over time. The activity of cilia is under supervision of multiple physiological regulators, including second messengers. Their role is to enable a movement in coordinated metachronal waves at certain beat frequency. Ciliary function can be modulated by various stimuli, including agents from the group of beta 2 agonists, cholinergic drugs, and adenosine triphosphate (ATP). They trigger cilia to move faster in response to elevated cytoplasmic Ca 2+ originated from intracellular sources or replenished from extracellular space. Well-known cilia-stimulatory effect of Ca 2+ ions can be abolished or even reversed by modulating the phosphodiesterase (PDE)-mediated breakdown of cyclic adenosine monophosphate (cAMP) since the overall change in ciliary beating has been dependent on the balance between Ca 2+ ions and cAMP. Moreover, in chronic respiratory diseases, high ATP levels may contribute to cAMP hydrolysis and thus to a decrease in the ciliary beat frequency (CBF). The role of PDE inhibitors in airway cilia-driven transport may help in prevention of progressive loss of pulmonary function often observed despite current therapy. Furthermore, administration of selective PDE inhibitors by inhalation lowers the risk of their systemic effects. Based on this review we may conclude that selective (PDE1, PDE4) or dual PDE inhibitors (PDE3/4) increase the intracellular level of cyclic nucleotides in airway epithelial cells and thus may be an important target in the development of new inhaled mucokinetic agents. Further research is required to provide evidence of their effectiveness and feasibility regarding their cilia-modulating properties.

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“…It enhances blood flow by improving the elasticity of erythrocytes and leukocytes. It also prevents platelets from clumping together [9].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study between the effect of Pentoxifylline and Low Dose Aspirin on Uterine Artery Blood Flow in Patients with Unexplained Infertility

Ali

El-Dorf

El-Shorbagy

et al. 2021

JAMMR

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Background: Infertility is customarily defined as the inability to conceive after 1 year of regular unprotected intercourse. The Practice Committee of the American Society for Reproductive Medicine (ASRM) has published guidelines for a standard infertility evaluation. It includes a semen analysis, assessment of ovulation, a hysterosalpingogram, and, if indicated, tests for ovarian reserve and laparoscopy. The aim of this study was to compare the possible changes in uterine artery doppler indices after the use of pentoxifylline and low dose aspirin in patients with unexplained fertility. Methods: This prospective comparative clinical study was conducted on patients age between 20 and 35 years old, body mass index (BMI) from 18 – 25 kg/m2, with unexplained infertility. Patients were divided into two equal groups: low dose aspirin group and pentoxifylline group. All patients were subjected to personal, husband, sexual and menstrual history taking, clinical examination, routine infertility investigations [Husband semen analysis, Hormonal investigation (FSH, LH, midluteal progesterone, prolactin, TSH)], hysterosalpingogram, laparoscope and transvaginal ultrasound. Results: There was no significant difference between both groups regarding age, BMI, occupation, residency, parity, type/duration of infertility, menstrual regularity/amount, dysmenorrhea, sexual intercourse frequency, using of lubricant or vaginal douching. There was no significant difference between the studied groups regarding FSH, LH, TSH, basal uterine artery RI and PI and S/D ratio at one and three months. Conclusions: In women with unexplained infertility, there was no significant difference between the effect of pentoxifylline and low dose aspirin on the uterine artery blood flow or Doppler indices (RI, PI and S/D ratio).

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Relating the blood-thinning effect of pentoxifylline to the reduction in the elastic modulus of human red blood cells: anin vivostudy

Abstract: Atomic force microscopy indentation was employed to illustrate that pentoxifylline reduces the elastic modulus of red blood cells (from healthy human subjects), increasing hence their flexibility.

Cited by 11 publications

References 21 publications

Effects of Pentoxifylline in a Rat Model of Manganism: Evaluation of the Possible Toxicity

Effects of Pentoxifylline in a Rat Model of Manganism: Evaluation of the Possible Toxicity

Respiratory Cilia as a Therapeutic Target of Phosphodiesterase Inhibitors

A Comparative Study between the effect of Pentoxifylline and Low Dose Aspirin on Uterine Artery Blood Flow in Patients with Unexplained Infertility

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