Relation between abdominal subcutaneous fat tissue thickness and inflammatory markers during pregnancy

Köşüş, Nermin; Köşüş, Aydın; Turhan, Nilgün Öztürk

doi:10.5114/aoms.2014.44865

Cited by 26 publications

(20 citation statements)

References 44 publications

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“…Data from the Framingham Heart Study demonstrated that both visceral and subcutaneous fat volume are associated with an increased risk of metabolic syndrome, with visceral fat showing a stronger relation . Greater maternal abdominal subcutaneous fat thickness has been shown to correlate with higher serum levels of hemoglobin A1C and C reactive protein in pregnant women . Recently, the utility of maternal abdominal subcutaneous fat thickness (SCFT) as a measure of abdominal obesity in pregnancy and as a predictor of pregnancy outcomes has been explored .…”

Section: Introductionmentioning

confidence: 99%

“…6 Greater maternal abdominal subcutaneous fat thickness has been shown to correlate with higher serum levels of hemoglobin A1C and C reactive protein in pregnant women. 7 Recently, the utility of maternal abdominal subcutaneous fat thickness (SCFT) as a measure of abdominal obesity in pregnancy and as a predictor of pregnancy outcomes has been explored. 8,9 Suresh et al 8 retrospectively studied 1200 nulliparous women and found an ultrasound measurement of abdominal SCFT was better than BMI at predicting gestational diabetes, cesarean delivery and large-for-gestational-age neonates.…”

Section: Introductionmentioning

confidence: 99%

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Increased maternal abdominal subcutaneous fat thickness and body mass index are associated with increased cesarean delivery: A prospective cohort study

Eley

Sekar

Chin

et al. 2018

Acta Obstet Gynecol Scand

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Introduction Early pregnancy body mass index (BMI) is known to predict adverse pregnancy outcomes but does not account for body fat distribution. This study aimed to determine prospectively whether maternal abdominal subcutaneous fat thickness (SCFT) measured by ultrasound at the fetal morphology scan is a better predictor than BMI of mode of delivery and other pregnancy outcomes. Material and methods This was a prospective cohort study of women delivering singleton neonates at a tertiary public hospital. Women were included if they had appropriate images at the routine fetal anomaly ultrasound scan and delivered in the facility. The primary outcome was mode of delivery categorized as cesarean section or vaginal delivery. The relation between maternal SCFT and BMI was described using the Pearson correlation coefficient. The association of maternal abdominal SCFT BMI at booking‐in was compared with pregnancy outcomes using univariate linear and logistic regression. Results SCFT and BMI were obtained for 997 women. The median (interquartile range) SCFT was 15.3 mm (12.8‐19.6) and median (interquartile range) BMI 24.3 kg/m2 (21.7‐28.3). Maternal abdominal SCFT and BMI were highly correlated (R2 = 0.55). Both were significantly associated with cesarean delivery: SCFT per 5 mm (odds ratio [OR] 1.32, 95% confidence interval (CI) 1.18‐1.48; BMI per 5 kg/m2 OR 1.29, 95% CI 1.15‐1.44. Conclusions Maternal abdominal SCFT and BMI were both significantly associated with cesarean delivery and other outcomes. More research is needed to define the strengths of maternal SCFT in predicting pregnancy outcomes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increased maternal abdominal subcutaneous fat thickness and body mass index are associated with increased cesarean delivery: A prospective cohort study

Eley

Sekar

Chin

et al. 2018

Acta Obstet Gynecol Scand

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“…In recent studies, the authors concluded that EAT acts as an extremely active organ that produces several bioactive adipokines, as well as proinflammatory and proatherogenic cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)-6, resistin, visfatin, omentin, leptin, plasminogen activator inhibitor-1 (PAI-1) and angiotensinogen [15, 18–21]. In addition, abdominal subcutaneous fat tissue was also found to be closely associated with inflammation in physiologic conditions such as pregnancy [22]. …”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio as a possible indicator of epicardial adipose tissue in patients undergoing hemodialysis

Özçiçek

Yıldız

Timuroğlu

et al. 2017

aoms

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IntroductionChronic inflammation is a major risk factor in the pathogenesis of cardiovascular disease in end-stage renal disease (ESRD) patients. Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease and EAT was shown in healthy subjects and ESRD patients. In the present study we aimed to investigate the relationship between EAT and inflammation parameters including neutrophil-to-lymphocyte ratio (NLR) in hemodialysis (HD) patients.Material and methodsForty-three HD patients (25 females, 18 males; mean age: 64.1 ±11.9 years) receiving HD and 30 healthy subjects (15 females, 15 males; mean age: 59.1 ±10.8 years) were enrolled in the study. Epicardial adipose tissue measurements were performed by echocardiography.ResultsNeutrophil-to-lymphocyte ratio levels were significantly higher in HD patients than in the healthy control group. Hemodialysis patients were separated into two groups according to their median value of NLR (group 1, NLR < 3.07 (n = 21) and group 2, NLR ≥ 3.07 (n = 22)). Group 2 patients had significantly higher EAT, C-reactive protein and ferritin levels, while albumin levels were significantly lower in this group. In the bivariate correlation analysis, EAT was positively correlated with NLR (r = 0.600, p < 0.001) and ferritin (r = 0.485, p = 0.001) levels.ConclusionsNeutrophil-to-lymphocyte ratio was found to be an independent predictor of EAT in HD patients (odds ratio = 3.178; p = 0.008). We concluded that this relationship might be attributed to increased inflammation in uremic patients.

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“…This finding is clinically significant as higher inflammation might contribute to the increased acute and chronic risk for the development of metabolic complications (e.g. insulin resistance, gestational diabetes, hypertension, metabolic syndrome, cardiovascular disease) (Catalano et al 2009a; Kosus et al 2014; Ozgu-Erdinc et al 2014) as well as additional risks for maternal infection, preterm delivery, and severe preeclampsia (Schmatz et al 2010). Additionally, higher inflammation in inactive obese women during pregnancy will likely persist into postpartum (Christian and Porter 2014); thus, potentially contributing to a higher long-term diabetes and cardiovascular disease risk (Lagrand et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Maternal inflammation during late pregnancy is lower in physically active compared with inactive obese women

Tinius

Cahill

Strand

et al. 2016

Appl. Physiol. Nutr. Metab.

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Purpose The primary purpose of this study was to compare maternal plasma inflammation between physically active and inactive obese women during late pregnancy. The secondary purpose was to examine the relationships between maternal plasma inflammation and lipid metabolism and maternal and neonatal metabolic health in these women. Methods A cross-sectional, observational study design was performed in 16 obese-inactive ((OBI) age: 25.0 ± 4.8 years, pre-pregnancy BMI: 36.3 ± 4.3kg/m2, body fat percentage in late gestation: 37.7 ± 3.5%) and 16 obese-active ((OBA) age: 28.9 ± 4.8 years, pre-pregnancy BMI: 34.0±3.7kg/m2, body fat in late gestation: 36.6 ± 3.8%) women during the third trimester of pregnancy. Maternal plasma inflammation (C -reactive protein (CRP)) and insulin resistance (Homeostatic Model Assessment-Insulin Resistance (HOMA-IR)) were measured at rest. Plasma lipid concentration and metabolism (lipid oxidation and lipolysis) were measured at rest, during a 30-minute bout of low-intensity (40% VO2peak) exercise, and during a resting recovery period using indirect calorimetry. Umbilical cord blood was collected for measurement of neonatal plasma insulin resistance, inflammation, and lipid concentration. Neonatal body composition was measured via air displacement plethysmography. Results Maternal plasma CRP concentration was significantly higher in OBI compared to OBA women (9.1 ± 4.0 mg/L versus 6.3 ±2.5mg/L, p=0.02). Maternal plasma CRP concentration was significantly associated with maternal lipolysis (r=0.43, p=0.02), baseline lipid oxidation rate (r=0.39, p=0.03), and baseline plasma free fatty acid concentration (r=0.36, p=0.04). Conclusions Maternal physical activity may reduce inflammation during pregnancy in obese women. Maternal lipid metabolism is related to systemic inflammation.

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Relation between abdominal subcutaneous fat tissue thickness and inflammatory markers during pregnancy

Cited by 26 publications

References 44 publications

Increased maternal abdominal subcutaneous fat thickness and body mass index are associated with increased cesarean delivery: A prospective cohort study

Increased maternal abdominal subcutaneous fat thickness and body mass index are associated with increased cesarean delivery: A prospective cohort study

Neutrophil-to-lymphocyte ratio as a possible indicator of epicardial adipose tissue in patients undergoing hemodialysis

Maternal inflammation during late pregnancy is lower in physically active compared with inactive obese women

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