Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction

Abstract

Apolipoprotein E (ApoE) is a plasma protein and associated with cholesterol transport system. In several studies, the relationship between ApoE gene polymorphism and severity of coronary artery disease (CAD) has been shown. However, the relationship between ApoE gene polymorphism and severity of CAD in patients with acute myocardial infarction (MI) has not been well known. The aim of this study is to investigate the relation between ApoE polymorphism and severity of CAD in patients with acute MI by using the Gensini Score. In this study, 138 patients were admitted to cardiology clinic with diagnosis of acute MI, and angiographic assessment was performed using the Gensini Score. Blood samples were obtained from all patients in the first day. The patients with ApoE34 genotype had high Gensini scores. Besides, the patients with E4 allele carriers were associated with high Gensini score compared with the patients without E4 allele carriers (p:0,22). The patients with E4 allele carriers were associated with higher LDL cholesterol and total cholesterol compared with the patients without E4 allele carriers (p:0,001 and p:0,03, resp.). There were no statistically significant differences between ApoE genotypes and severity of CAD by using the Gensini Score. But, the patients with E4 allele carriers were associated with high lipid levels.

A 6-Month Follow-Up Study of the Relation between Apolipoprotein E Gene Polymorphism and Major Adverse Cardiovascular Events in Patients with Acute Coronary Syndrome

“…This result is consistent with previous studies [5,6,13]. The study team of Dr. Zülküf Karahan [5] aimed to investigate the relationship between ApoE gene polymorphism and severity of CAD in patients with acute MI. They found that both the levels of LDL cholesterol and TC were observed to be higher in the ApoE34 genotype than in the other genotypes.…”

“…They found that both the levels of LDL cholesterol and TC were observed to be higher in the ApoE34 genotype than in the other genotypes. Many studies concluded that the ApoE4 allele is associated with higher serum levels of TC, LDL cholesterol, and VLDL cholesterol, and higher risk of CAD [5,6,13].…”

“…ApoE gene polymorphisms include 3 isoforms called ApoE2, ApoE3, and ApoE4, which give rise to 6 different genotypes: E2/E2, E2/E3, E3/E3, E2/E4, E3/E4, and E4/E4 [4]. Previous studies have shown that E4 allele carriers suffering from acute myocardial infarction (MI) were associated with higher low-density lipoprotein (LDL) cholesterol and total cholesterol (TC) levels [5]; ApoE gene polymorphisms are associated with coronary artery disease (CAD) and affect the lipid profile. The E4 allele is an independent risk factor for CAD [6].…”

Associação Entre O Polimorfismo Do Gene Da Apolipoproteína E E Fatores De Risco Cardiovasculares Em Idosos

“…Tais resultados corroboram um estudo que analisou a associação entre o genótipo da ApoE e DCVs, verificando que a gravidade das lesões coronarianas em idosos não apresentou associação com o alelo ɛ4 (13) . Outros estudos realizados com indivíduos idosos, verificando a associação do alelo ɛ4 com complicações cardiovasculares encontraram resultados controversos (16)(17) . Nessa mesma linha, não se observou associação entre os valores alterados de lipídios, glicemia, variáveis antropométricas e pressão arterial entre os diferentes genótipos da ApoE em uma população de idosos, verificando apenas aumento de HDL-colesterol no grupo de idosos considerados fisicamente ativos e portadores do alelo ɛ4.…”

Transcription factor 21 gene polymorphism in patients with coronary artery disease

“…1 Many risk factors contribute to the pathogenesis of CAD, such as smoking, diabetes, hypertension, hypercholesterolemia, obesity, physical inactivity and stress. 2 Although many patients with CAD share similar risk factors, it is not clear why some individuals are more susceptible to these environmental determinants than others with the same risk factors, pointing to a complex interaction of both environmental and genetic factors.…”