Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population

Curran‐Celentano, Joanne; Hammond, Billy R.; Ciulla, Thomas A.; Cooper, David C.; Pratt, Linda; Danis, Ronald B.

doi:10.1093/ajcn/74.6.796

Cited by 165 publications

(111 citation statements)

References 22 publications

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“…Some studies report that men have higher (13-30%) MPOD than women, whereas others deny any relationship. [27][28][29] The Indian MPOD normative data study found no significant association of overall MPOD with gender (unpublished data), which is consistent with the present study.…”

Section: Discussionsupporting

confidence: 89%

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Association of macular pigment optical density with risk factors for wet age-related macular degeneration in the Indian population

Raman

Biswas

Gupta

et al. 2012

Eye

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Purpose To investigate macular pigment optical density (MPOD) in patients with and without wet age-related macular degeneration (AMD) and to elucidate the association between MPOD and the risk factors for AMD in an Indian population. Methods Thirty-three subjects with wet AMD and 29 controls above 50 years old underwent MPOD measurement with the 'Macular Densitometer'. The subjects were also tested for their smoking history, lifetime ultraviolet (UV) exposure, dietary intake of carotenoids, and body mass index (BMI). Results Smokers had a higher risk for AMD than the non-smokers (P ¼ 0.032) and a lower MPOD level than non-smokers (mean (95% CI)) (0.16 (0.09-0.23) vs 0.28 (0.22-0.34), adjusted P ¼ 0.026). Subjects with lowest UV exposure had higher MPOD than those with the highest (0.46 (0.38-0.54) vs 0.17 (0.01-0.33), P ¼ 0.01). MPOD was significantly lower among those with the lowest quartile of dietary intake of carotenoids (0.14 (0.08-0.21) vs 0.25 (0.13-0.36), P ¼ 0.012). Smoking, obesity, and UV index showed an inverse association with the MPOD. Low MPOD, smoking, and UV exposure had 5.11 (1.73-15.08), 3.54 (1.08-11.57), and 5.24 (1.06-25.96) odds for AMD, respectively, whereas higher dietary intake of carotenoids showed a protective effect for AMD. Conclusion We found an inverse association between wet AMD and MPOD. Among the established risk factors of wet AMD, we found an inverse association of smoking, UV index, and obesity with MPOD, whereas a positive association was found between dietary intake of carotenoids and MPOD. Eye (2012) 26, 950-957;

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Section: Discussionsupporting

confidence: 89%

“…14,[28][29][30][31][32][33] We found that MPOD was 48% higher in the highest level of dietary intake of carotenoids, which was previously reported to be 19-31%. 14,31,32 The regression model eventually obtained is presented in Table 6.…”

Section: Discussionmentioning

confidence: 72%

Association of macular pigment optical density with risk factors for wet age-related macular degeneration in the Indian population

Raman

Biswas

Gupta

et al. 2012

Eye

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“…Serum concentrations for b-carotene and vitamin C were much higher in women than in men, as previously found in numerous studies performed in different countries (Hercberg et al, 1994;Curran-Celentano et al, 2001;De Waart et al, 2001;Wallstrom et al, 2001;Olmedilla et al, 2002). This may be related to the better b-carotene and vitamin C nutrient density for these nutrients usually consumed by women than by men and to some life-type factors observed more in men than in women of the cohort such as smoking or drinking alcoholic beverages, which are known to decrease the b-carotene and vitamin C serum levels.…”

Section: Discussionsupporting

confidence: 82%

Serum concentrations of β-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population

Fe²,

et al. 2005

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Objective: To assess relationships between energy, nutrient and food intakes, alcohol consumption, smoking status and body mass index (BMI), and serum concentrations of b-carotene, a-tocopherol, vitamin C, selenium and zinc. Methods: Data on health status, alcohol consumption, smoking habits, anthropometric data and biochemical measurements were obtained in 1821 women aged 35-60 y and 1307 men aged 45-60 y, participant to the SU.VI.MAX Study. Data on dietary intake were available on a subsample who reported six 24-h dietary records during the first 18 months of the study. Results: Women had higher baseline serum b-carotene and vitamin C concentrations and lower concentration for serum vitamin E, zinc and selenium than men. In women, younger age was associated with lowered mean concentration of serum b-carotene, vitamin E and selenium. In men, only differences were observed for serum zinc, which was lower in older men. Current smokers of both sexes had significantly lower concentrations of serum b-carotene, vitamin C and selenium, and, only in women, of vitamin E, than nonsmokers. Alcohol consumers had lower concentrations of serum b-carotene and higher selenium concentrations. Serum b-carotene and vitamin C concentrations were lower in obese subjects. There were positive associations of dietary b-carotene, vitamin C and E with their serum concentrations. Age, nutrient and alcohol intakes, serum cholesterol, BMI and smoking status explained 15.2% of the variance of serum b-carotene in men and 13.9% in women, and 10.8 and 10.0% for serum vitamin C, and 26.3 and 28.6% for serum vitamin E, respectively. Conclusion: Serum antioxidant nutrient concentrations are primarily influenced by sex, age, obesity, tobacco smoking, alcohol consumption and especially dietary intake of those antioxidant nutrients. IntroductionCigarette smoking, obesity and some dietary patterns are well-known risk factors for both cardiovascular disease and cancer (WCRF/AIC; Kromhout, 2001). Yet, in the past several years, an increasing number of basic and clinical studies have pointed to the role of the reactive metabolites of oxygen, the free radicals, in these pathological processes, and the potential protective effect of antioxidant nutrients such as bcarotene, vitamin C, vitamin E, selenium and zinc (Ames, Halliwell & Gutteridge, 1989;Diplock, 1991;Byers & Perry, 1992;Frei, 1994;Hercberg et al, 1998a).Epidemiological data from cross-sectional, case-control, and prospective studies have shown a strong relationship between the intake of foods rich in antioxidant vitamins and minerals, or the actual intake of these nutrients, and the risk of cancer and ischaemic cardiovascular diseases (CVD) (Block et al, 1992;Stampfer & Rimm, 1993;Byers & Guerrero, 1995;Kohlmeier & Hastings, 1995;Stampfer & Rimm, 1995;Hercberg et al, 1998a). However, most of published randomized placebo-controlled primary prevention trials have not been able to demonstrate these potential beneficial effects (Blot et al, 1993; The AlphaTocopherol, Beta Carotene Cancer Preventi...

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“…13,14 Subsequent studies have suggested a number of parameters such as age, diet, percentage body fat, gender and tobacco use [15][16][17][18][19] might be determinants of MP; however, these only account for approximately a third of the variance leaving a significant proportion unexplained. In addition, despite MP's dietary origin only modest correlations exist with serum and dietary levels of L and Z.…”

Section: Introductionmentioning

confidence: 99%

Heritability of the spatial distribution and peak density of macular pigment: a classical twin study

Hogg

Ong

Chamberlain

et al. 2012

Eye

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Purpose To elucidate the heritability of peak density and spatial width of macular pigment (MP) using a Classical Twin Study. Methods Fundus autofluorescence images were obtained at 488 nm from 86 subjects or 43 twin pairs (21 monozygotic (MZ) and 22 dizygotic (DZ)) (27 male, 59 female) aged from 55 to 76 years (mean 62.2 ± 5.3 years). The relative topographic distribution of MP was measured using a grey scale of intensity (0-255 units) in a 71 eccentricity around the fovea. Relative peak MP density (rPMPD) and relative spatial distribution of MP (rSDMP) were used as the main outcome measure in the statistical analysis. Results A significantly higher correlation was found within MZ pairs as compared with that within DZ pairs for rPMPD, (r ¼ 0.99, 95% confidence interval (95% CI) 0.93 to 1.00) and 0.22, 95% CI À 0.34 to 0.71), respectively, suggesting strong heritability of this trait. When rSDMP was compared, there was no significant difference between the correlations within MZ pairs (r ¼ 0.48, 95% CI À 0.02 to 0.83) and DZ pairs (r ¼ 0.63, 95% CI 0.32 to 0.83), thus rSDMP is unlikely to have a considerable heritable component. In addition, there was no difference between any MP parameter when normal maculae were compared with early age-related macular degeneration (AMD) (rPMPD 0.36 vs 0.34, t ¼ 1.18 P ¼ 0.243, rSDMP 1.75 vs 1.75, t ¼ 0.028 P ¼ 0.977). Conclusions rPMPD is a strongly heritable trait whereas rSDMP has minimal genetic influence and a greater influence by environmental factors. The presence of macular changes associated with early AMD did not appear to influence any of these pigment parameters.

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Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population

Cited by 165 publications

References 22 publications

Association of macular pigment optical density with risk factors for wet age-related macular degeneration in the Indian population

Association of macular pigment optical density with risk factors for wet age-related macular degeneration in the Indian population

Serum concentrations of β-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population

Heritability of the spatial distribution and peak density of macular pigment: a classical twin study

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