Relation between fibrinolytic activity and prostacyclin generation of atherosclerotic artery and dacron prosthetic graft

Abstract

The newly formed tissue of dacron vascular prosthetic grafts implanted in humans demonstrates prostacyclin generation and fibrinolytic activity comparable to that of the atherosclerotic artery in the vicinity. This provides some evidence that both activities important for haemostasis run parallel.

Activity and Distribution of Superoxide Dismutase in the Layers of Polyester Grafts

“…12], inflammation [13. 14], degenerative changes [ 10,28] and other vascular graft com plications leading to rapid occlusion in the materials by thrombogenesis [7,9,12], Depending on the extent of healing, the implanted graft is in continuous contact with ROMs formed in various blood vessel wall cells. This creates favorable conditions for the progress of radical reactions, a state called oxidative stress [15,16,30], Thus, the fate of an implanted graft is determined by hemo static balance [3.…”

“…Low SOD activity in all the graft layers (particularly in the neointima) in the second healing phase may disturb the pace and nor mal course of polyester prosthesis healing, and in prostheses already healed and covered with endothelium, it may lead to endothelial 372 EurSurg Res 1997:29:368-374 G lo w inski/F arbiszcw ski/G lciw inski/ C hw iecko damage [24] and degenerative and thrombot ic alterations due to a lowering of prostacyclin synthesis [10,32], resulting in graft occlusion. Since a-tocopherol also results in a propor tional increase in oxidative resistance of en dothelial cell membranes against oxidative in jury and restores normal endothelial cell func tion [36], its supplementation might be of a value during this healing period.…”

“…Three graft layers, similar to the normal artery layers, are formed during the prosthesis healing process [1,3,4], The biological role of the layers and particularly that of the inner layer is manifold: it participates in the main tenance of the implanted prosthesis patency and prevents or promotes thrombus forma tion, inflammation or degenerative changes [3,4,7,8,[10][11][12], These layers have been shown to possess many compounds having an influence on early surface bioreactivity and long-term graft patency [5][6][7]12], compounds affecting mainly the hemostasis system such as antiheparin substances [4], thromboplastin [3], tissue plasminogen activator [3,10] and prostacyclin [10]. Recently, oxygen-derived free radicals have been found in graft layers [unpubl.…”

“…They interact with blood platelets and leukocytes and in fluence the components of the blood-clotting and fibrinolysis system [2][3][4][7][8][9][10].…”

The initial blood retention properties of arterial prostheses

“…The exact mechanism of the acute [13][14][15] thrombotic response during blood-biomaterial interaction is still poorly understood [16,17]. Depending upon the level of thrombogenicity of the artificial material and the thrombohematological properties of blood, the thrombotic matrix will vary widely, and thus may be the determining factor in the fate of the graft [18][19][20][21][22][23].…”