Relation between gastric secretion of acid and urinary excretion of calcium after oral supplements of calcium

Hunt, J. N.; Johnson, Carolyn

doi:10.1007/bf02430530

Cited by 21 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have shown that the absorption of calcium carbonate is more dependent on gastric acid secretion than calcium citrate [31–36]. A previous study in healthy, postmenopausal women with varying degrees of gastric acid secretion reported a 2.5-fold higher intestinal calcium absorption following a single test load of calcium citrate than calcium carbonate [37].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Absorption of Calcium Carbonate and Calcium Citrate after Roux-en-Y Gastric Bypass

Provost²,

et al. 2009

View full text Add to dashboard Cite

Introduction Roux-en-Y gastric bypass (RYGB) restricts food intake. Consequently, patients consume less calcium. In addition, food no longer passes through the duodenum, the main site of calcium absorption. Therefore, calcium absorption is significantly impaired. The goal of this study is to compare two common calcium supplements in gastric bypass patients. Method Nineteen patients were enrolled in a randomized, double-blinded, crossover study comparing the absorption of calcium from calcium carbonate and calcium citrate salts. Serum and urine calcium levels were assessed for peak values (Cmax) and cumulative calcium increment (area under the curve [AUC]). Serum PTH was assessed for minimum values (PTHmin) and cumulative PTH decrement (AUC). Statistical analysis was performed using a repeated analysis of variance model. Results Eighteen subjects completed the study. Calcium citrate resulted in a significantly higher serum Cmax (9.4+0.4 mg/dl vs. 9.2+0.3 mg/dl, p=0.02) and serum AUC (55+2 mg/dl vs. 54+2 mg/dl, p=0.02). Calcium citrate resulted in a significantly lower PTHmin (24+11 pg/ml vs. 30+13 pg/ml, p=0.01) and a higher AUC (−32+51 pg/ml vs. −3+56 pg/ml, p=0.04). There was a non-significant trend for higher urinary AUC in the calcium citrate group (76.13+36.39 mg/6 h vs. 66.04+40.82, p=0.17). Conclusion Calcium citrate has superior bioavailability than calcium carbonate in RYGB patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of the Absorption of Calcium Carbonate and Calcium Citrate after Roux-en-Y Gastric Bypass

Provost²,

et al. 2009

View full text Add to dashboard Cite

show abstract

“…However, the association with enteric flaps and laparotomy probably represents a combination of more extensive resection and the use of jejunostomy feeding tubes. Calcium absorption not only depends on vitamin D3 and parathyroid hormone, but on low pH for ionization, and hence its solubility 2 . Bypassing the stomach alone will not affect postoperative serum calcium; however, in patients with borderline parathyroid function, it may alter the balance.…”

Section: Discussionmentioning

confidence: 99%

Morbidity After Flap Reconstruction of Hypopharyngeal Defects

et al. 2006

View full text Add to dashboard Cite

show abstract

“…It has been previously shown that CCC absorption and solubility are proportional to gastric acid secretion. (36) Therefore, this result calls for further studies that control for fasting and nonfasting states.…”

Section: Discussionmentioning

confidence: 99%

Increased Calcium Absorption From Synthetic Stable Amorphous Calcium Carbonate: Double-Blind Randomized Crossover Clinical Trial in Postmenopausal Women

Vaisman

Shaltiel

Daniely

et al. 2014

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Calcium supplementation is a widely recognized strategy for achieving adequate calcium intake. We designed this blinded, randomized, crossover interventional trial to compare the bioavailability of a new stable synthetic amorphous calcium carbonate (ACC) with that of crystalline calcium carbonate (CCC) using the dual stable isotope technique. The study was conducted in the Unit of Clinical Nutrition, Tel Aviv Sourasky Medical Center, Israel. The study population included 15 early postmenopausal women aged 54.9 AE 2.8 (mean AE SD) years with no history of major medical illness or metabolic bone disorder, excess calcium intake, or vitamin D deficiency. Standardized breakfast was followed by randomly provided CCC or ACC capsules containing 192 mg elemental calcium labeled with 44 Ca at intervals of at least 3 weeks. After swallowing the capsules, intravenous CaCl 2 labeled with 42 Ca on was administered on each occasion. Fractional calcium absorption (FCA) of ACC and CCC was calculated from the 24-hour urine collection following calcium administration. The results indicated that FCA of ACC was doubled (AE 0.96 SD) on average compared to that of CCC (p < 0.02). The higher absorption of the synthetic stable ACC may serve as a more efficacious way of calcium supplementation.

show abstract

Relation between gastric secretion of acid and urinary excretion of calcium after oral supplements of calcium

Cited by 21 publications

References 9 publications

Comparison of the Absorption of Calcium Carbonate and Calcium Citrate after Roux-en-Y Gastric Bypass

Comparison of the Absorption of Calcium Carbonate and Calcium Citrate after Roux-en-Y Gastric Bypass

Morbidity After Flap Reconstruction of Hypopharyngeal Defects

Increased Calcium Absorption From Synthetic Stable Amorphous Calcium Carbonate: Double-Blind Randomized Crossover Clinical Trial in Postmenopausal Women

Contact Info

Product

Resources

About