Relation between insulin-like growth factor-I concentrations, osteoarthritis, bone density, and fractures in the general population: the Chingford study.

Lloyd, Mark; Dj, Hart; Nandra, D.; McAlindon, Timothy E.; Wheeler, M; Doyle, D V; Spector, Tim D.

doi:10.1136/ard.55.12.870

Cited by 65 publications

(45 citation statements)

References 18 publications

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“…The risk profile for OA may vary depending on which joint or joint groups are involved. For instance, several well-established risk factors for knee OA, such as obesity and high bone mineral density, have not been shown consistently to increase the risk of hand OA (21)(22)(23)(24). In addition, the impact of risk factors may be different even among hand joints (25).…”

Section: Discussionmentioning

confidence: 99%

Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: The Beijing Osteoarthritis Study

Zhang

Nevitt

et al. 2003

Arthritis & Rheumatism

121

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Objective. Fewer Chinese subjects in Beijing have hip osteoarthritis (OA) compared with whites in the United States, but as many or more Chinese subjects have knee OA. If these differences are due to a systemic predilection for disease, then the prevalence of hand OA, the best indicator of generalized disease, should be different in China. The goals of this study were to estimate the prevalence of hand OA among elderly Chinese in Beijing, and to compare it with that among elderly whites in the United States.Methods. We recruited a random sample of Beijing residents ages >60 years. Subjects answered questions on joint symptoms and provided posteroanterior radiographs of the hand. The protocol was identical to that used in the Framingham, Massachusetts OA Study. The hand radiographs from the Beijing OA Study were read intermingled with films from the Framingham OA Study. We defined a hand joint as having radiographic OA if it had a Kellgren and Lawrence grade >2. Symptomatic OA was present when both radiographic OA and self-reported pain were present in the same joint. We classified a subject as having radiographic or symptomatic hand OA if at least 1 hand joint had radiographic or symptomatic OA. We estimated the prevalence of hand OA in elderly subjects in Beijing and compared it with the prevalence of hand OA in elderly subjects from Framingham, using an age-standardized prevalence ratio.Results. We obtained both symptom information and hand radiographs from 2,525 subjects. Despite the older age of the group, only 44.5% of men and 47.0% of women had radiographic hand OA. Symptomatic hand OA occurred in 3.0% of men and 5.8% of women. Compared with white men in Framingham, the Beijing Chinese men had a much lower prevalence of radiographic hand OA (age-adjusted prevalence ratio 0.64, 95% confidence interval [95% CI] 0.58-0.70) and symptomatic hand OA (age-adjusted prevalence ratio 0.25, 95% CI 0.16-0.34). The proportion of multiple hand joints affected by OA in Chinese men was also significantly lower than in white men. A similar magnitude of difference was also observed in the women. However, prevalence of symptomatic OA at the metacarpophalangeal (MCP) joints in Chinese men and prevalence of radiographic OA at the MCP joints in Chinese women were similar to those in their white counterparts in Framingham.Conclusion. Elderly Chinese subjects in Beijing had a much lower prevalence of hand OA than did elderly whites in Framingham, Massachusetts. Coupled with the exceedingly low prevalence of hip OA in China, these results may suggest that the overall predilection for OA is less among subjects in China than among whites in the United States.Using a uniform definition of osteoarthritis (OA) across populations, we recently reported that elderly

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Section: Discussionmentioning

confidence: 99%

Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: The Beijing Osteoarthritis Study

Zhang

Nevitt

et al. 2003

Arthritis & Rheumatism

121

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“…In contrast, Trojan et al did not observe any associations between IGF-I levels and QOL measurements among 112 patients with post -polio syndrome (19). The mechanism of the potential influence of the IGF proteins on QOL is unclear, although the IGF/growth hormone axis has been correlated with improved organ functions, such as those of the brain (20) and heart (21,22) as well as bone density (23), which may lead to enhanced physical and psychological wellbeing. To our knowledge, no such studies have examined the relationship between this important family of proteins and QOL in cancer patients.…”

Section: Introductionmentioning

confidence: 92%

Associations between Plasma Insulin-Like Growth Factor Proteins and C-Peptide and Quality of Life in Patients with Metastatic Colorectal Cancer

Meyerhardt

Sargent

Goldberg

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Objective: Predictors of quality of life (QOL) in patients with metastatic colorectal cancer are lacking. The insulin-like growth factor (IGF) family of proteins is associated with QOL in noncancer populations. We sought to study whether these proteins are associated with QOL in patients with colorectal cancer. Method: We used a cohort of 526 patients with metastatic colorectal cancer treated with combination chemotherapy. Plasma samples of IGF-I, IGF-II, IGF binding protein-3, and C-peptide were collected before initiation of chemotherapy. QOL was measured by the uniscale instrument and the Symptom Distress Scale at baseline and throughout treatment. Results: Baseline plasma levels of IGF-I and IGF-II before initiation of chemotherapy were significantly associated with several important baseline QOL measures in patients with metastatic colorectal cancer. Patients with lower levels of IGF-I reported increased distress with regard to appearance, appetite, cough, and nausea intensity after adjustment for potential confounders. Similarly, decreased levels of IGF-II were predictive of worse quality related to appearance, appetite, fatigue, nausea frequency and intensity, pain frequency, and composite Symptom Distress Scale score. IGF binding protein-3 and C-peptide were not predictive of baseline QOL. Baseline biomarkers were not associated with subsequent changes in QOL during treatment. Higher body mass index was significantly associated with superior baseline QOL in several areas; nonetheless, the association of IGF-I and IGF-II with baseline QOL measures remained significant even after controlling for baseline body mass index. Conclusion: Baseline plasma IGF-I and IGF-II are significantly associated with symptom distress. Whether this association is simply reflective of patient nutritional status and/or disease burden or represents an independent biological effect of IGFs on QOL remains uncertain. Nonetheless, these data suggest that molecular biomarkers may be useful predictors of QOL in cancer patients. (Cancer Epidemiol Biomarkers Prev 2005;14(6):1402 -10)

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“…IGF-I can also be synthesized by chondrocytes. 27 This peptide is vital for childhood growth, but continues to have anabolic affects in adults. IGF-I is stimulated by growth hormones and helps cartilage maintain structural and functional integrity by inhibiting interleukin-1's ability to stimulate proteoglycan degredation.…”

Section: Insulin Growth Factor-imentioning

confidence: 99%

“…IGF-I is stimulated by growth hormones and helps cartilage maintain structural and functional integrity by inhibiting interleukin-1's ability to stimulate proteoglycan degredation. 27 However, under malnutrition conditions, hormone and receptor insensitivity, and failure to downstream signaling, can affect growth and stimulate damage to cartilage health. Past studies have shown that IGF-I can be important to the development of osteoarthritis and osteoporosis due to IGF-I being abundant in the cartilage and bone; therefore, it is suggested that it can prevent cartilage damage and the progression of osteoarthritis.…”

Section: Insulin Growth Factor-imentioning

confidence: 99%

Canine osteoarthritis and treatments: a review

Bland

2015

Vet Sci Develop

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Arthritis is a commonly occurring chronic illness in human and animals alike. Among all domestic and pet animal species, dogs suffer from arthritis more often because of excessive running or exercise, injury, and/or genetic predisposition. Presently, one in four of 77.2 million pet dogs in the United States are diagnosed with some form of arthritis. In dogs, osteoarthritis is more common than rheumatoid arthritis and pain is the number one observation. Osteoarthritis, also known as degenerative joint disease, is a slowly progressive inflammatory disease, which is characterized by degeneration of the cartilage, hypertrophy of bone at the margins, and changes in the synovial membrane, and that eventually results in pain and stiffness of joints. Alterations in joint structures, decreased flexibility, and severe pain ensues, due to lack of hydration and inflammation. Cells within the damaged joints release pro-inflammatory cytokines, which further the inflammatory process. This causes more breakdown of the cartilage collagen type II and proteoglycans, which results in a perpetual destructive cycle. This perpetuating cycle ultimately results in cartilage destruction, subchondral bone thickening, and synovial membrane inflammation. This review focuses on osteoarthritis, the disease, causes, treatments, and presents a glimpse of some new therapies under study.

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Relation between insulin-like growth factor-I concentrations, osteoarthritis, bone density, and fractures in the general population: the Chingford study.

Cited by 65 publications

References 18 publications

Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: The Beijing Osteoarthritis Study

Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: The Beijing Osteoarthritis Study

Associations between Plasma Insulin-Like Growth Factor Proteins and C-Peptide and Quality of Life in Patients with Metastatic Colorectal Cancer

Canine osteoarthritis and treatments: a review

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