Relation between Maternal and Neonatal Serum Lipid Profile and Their Impact on Birth Weight

Abdel-Hamid, Tamer A.; abdellatif, dalia; Ahmed, E.S.; Abdel-Rasheed, Mazen; A-Mageed, Ahmed

doi:10.1055/s-0040-1721690

Cited by 6 publications

(8 citation statements)

References 24 publications

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“…In addition, our study observed that increased TG levels in the first trimester were correlated with elevated risks of macrosomia, which was rarely studied previously. A negative association between TG levels and SGA was also found in the current study, which is consistent with several previous studies ( 12 , 40 ). In a word, TG exhibited a significant relationship with birth weight and adverse birth outcomes, indicating that TG might play an important role in fetal growth.…”

Section: Discussionsupporting

confidence: 94%

Maternal lipid profile during early pregnancy and birth weight: A retrospective study

Zhu

Zhang

et al. 2022

Front. Endocrinol.

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IntroductionElevated maternal serum lipid concentrations have been related to an adverse intrauterine environment and lead to abnormal birth weight.ObjectiveIn this study, we aimed to explore the association between maternal lipid profiles during early pregnancy and birth weight with stratified pre-pregnancy body mass index (BMI).MethodsThis retrospective cohort study was based on a large population from two major maternity centers in Shanghai, China. We included 57,516 women with singleton live birth between January 2018 and October 2020. All of the enrolled women had fasting lipid concentrations measured in early pregnancy. The primary outcomes were birth weight and risks of adverse birth outcomes, including macrosomia, large for gestational age (LGA), low birth weight (LBW), and small for gestational age (SGA).ResultsHigher maternal concentrations of total cholesterol (TC), triglyceride (TG), and low-density cholesterol (LDL-c) in early pregnancy were associated with increased birth weight. Ln transformed TG and levels exhibited a positive association with LGA and macrosomia (OR = 1.33, 95% CI: 1.25, 1.42 and OR = 1.37, 95% CI: 1.24, 1.52) and showed a negative relationship with SGA (OR = 0.73, 95% CI: 0.62, 0.85). High TG (>75th percentile, 1.67 mmol/L) group also showed higher risks of LGA and macrosomia (OR = 1.21, 95% CI: 1.15, 1.28 and OR = 1.20, 95% CI: 1.10, 1.31) and decreased prevalence of SGA (OR = 0.71, 95% CI: 0.61, 0.83). Moreover, significant combined effects of pre-pregnancy BMI and lipid profiles on LGA and macrosomia were identified.ConclusionsElevated maternal lipid profiles in early pregnancy are associated with higher birth weight and increased risks of LGA and macrosomia. We propose that serum lipid profiles in early pregnancy and pre-pregnancy BMI could serve as screening indexes for high-risk women.

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Section: Discussionsupporting

confidence: 94%

Maternal lipid profile during early pregnancy and birth weight: A retrospective study

Zhu

Zhang

et al. 2022

Front. Endocrinol.

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“…They differed in sample size, ranging from 119 to 5,282. Four of these included publications were cohort studies ( 12 – 14 , 17 ), two were case-control studies ( 15 , 18 ) and two were cross-sectional studies ( 11 , 16 ). They were conducted in different countries, Netherlands ( 12 ), China ( 13 ), Turkey ( 16 ), Japan ( 18 ), Korea ( 14 ), Canada ( 15 ), German ( 17 ) and Egypt ( 11 ) separately.…”

Section: Resultsmentioning

confidence: 99%

“…Each item was scored "0" if answered "No" or "Unclear"; when it was answered "Yes, " the item was scored "1." We considered articles as having low quality (scores of 0-3), moderate quality (scores of 4-7) or high quality (scores of [8][9][10][11].…”

Section: Study Selection Data Collection and Data Itemsmentioning

confidence: 99%

“…It has been well-established that SGA is associated with low pre-pregnancy body mass index (5), sleep disturbances (6), short stature (7), serum plasma protein A levels (8), smoking (9) and maternal antioxidant levels (10). Recently, gestational dyslipidemia has also been reported to be a risk factor for SGA infant delivery (11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

“…Preceding reviews have revealed that gestational dyslipidemia is associated with increased incidence of preterm delivery, hypertensive disorders and gestational diabetes mellitus, (26)(27)(28) but epidemiological evidence regarding SGA is conflicting. Some studies showed there was no association between maternal lipid levels during pregnancy and delivery of SGA,(12, 16, 17) whereas other reports found that gestational dyslipidemia could lead to SGA infant birth (11)(12)(13)(14)(15)18).…”

Section: Introductionmentioning

confidence: 99%

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Association between maternal lipid levels during pregnancy and delivery of small for gestational age: A systematic review and meta-analysis

Wang

Chen²,

Zhang³

2022

Front. Pediatr.

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BackgroundStudies investigating the relationship between gestational dyslipidemia and small for gestational age (SGA) have reported differing results. This review was performed to determine whether maternal lipid levels during pregnancy were associated with SGA.MethodsLiterature searches for relevant studies were conducted systematically from establishment until February 2022 with PubMed, Embase, Cochrane Library and Web of Science. Risk of bias was assessed with the Newcastle-Ottawa Scale and 11-item checklist. According to the classification of GHD parameters, meta-analyses reporting cases regarding total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) were performed respectively. If I2 ≥ 50%, considered to demonstrate substantial heterogeneity, the random effect model was employed. Otherwise, a fixed effect model was employed.ResultsEight studies (14,213 pregnancies) were included. Decreased levels of TC (MD −0.13; 95% CI −0.24 to −0.02), TG (MD −0.09; 95% CI −0.14 to −0.03) and LDL-C (MD −0.12; 95% CI −0.23 to −0.00) were risk factors for SGA infant birth. No evident association was observed between HDL-C and delivery of SGA (MD −0.08; 95% CI −0.19 to 0.02).ConclusionGestations complicated with dyslipidemia, especially lower concentrations of TC, TG and LDL-C, were at significantly higher risk of delivery of SGA.Systematic review registration[www.crd.york.ac.uk/prospero], identifier [CRD42022304648].

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Study of triglyceride changes during pregnancy and neonatal birth weight and adverse outcomes

Wei,

Tang,

Xia

et al. 2024

American J Hum Biol

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BackgroundChanges of maternal triglyceride concentrations are closely associated with intrauterine fetal growth and development, but the effect of mid‐ to late‐term triglyceride changes on birth weight is uncertain. This study investigated the association between changes in triglycerides in mid to late in pregnant women gestational age ≥ 35 weeks on neonatal birth weight and adverse outcomes.MethodsThis cohort study was based on 931 pregnant women with a singleton delivery at gestational age ≥ 35 weeks from January 1, 2022 to December 31, 2022 at Nanjing Lishui People's Hospital (NJLSPH) in China, with all maternal triglyceride concentrations measured at mid‐term and late‐term before delivery. The primary outcomes were neonatal birth weight and the risk of macrosomia.ResultsLate term triglyceride levels were positively associated with birth weight (β = 126.40, 95% CI: 61.95, 190.84, p < .001) and risk of macrosomia (OR = 2.11, 95% CI: 1.12, 3.98, p = .022). Late mid‐term triglyceride was positively associated with birth weight (β = 27.58, 95% CI: 9.67, 45.50, p = .003), and no correlation with risk of macrosomia (OR = 1.12, 95% CI: 0.95, 1.31, p = .178). Mid‐term triglyceride was not associated with birth weight (β = 45.79, 95% CI: −28.73, 120.30, p = .229) and risk of macrosomia (OR = 1.83, 95% CI: 0.89, 3.78, p = .101).ConclusionLate triglyceride levels were associated with birth weight and risk of macrosomia, while late to mid‐term triglyceride were associated with birth weight but not with risk of macrosomia. This suggests that maternal triglyceride changes may affect fetal growth and development, and more studies focusing on the effects of gestational triglyceride profiles are warranted.

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Relation between Maternal and Neonatal Serum Lipid Profile and Their Impact on Birth Weight

Cited by 6 publications

References 24 publications

Maternal lipid profile during early pregnancy and birth weight: A retrospective study

Maternal lipid profile during early pregnancy and birth weight: A retrospective study

Association between maternal lipid levels during pregnancy and delivery of small for gestational age: A systematic review and meta-analysis

Study of triglyceride changes during pregnancy and neonatal birth weight and adverse outcomes

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