Relation between mean platelet volume and C-reactive protein

Abstract

Mean platelet volume (MPV) is a measure of platelet activation, and C-reactive protein (CRP) is an established marker of inflammation. Studies on the correlation between MPV and CRP have produced ambiguous results. We undertook a population study with the National Health and Nutrition Examination Survey (NHANES) data (2005)(2006)(2007)(2008)(2009)(2010) to investigate the relationship between CRP and MPV. CRP was analyzed both as a continuous variable and as a categorical variable (low, intermediate, or high). Multivariate ordinary least squares regression analysis was used to predict the association. Statistical analyses were performed with Stata MP 15.1. In 16,329 participants, mean MPV was 7.9 fL (standard deviation 0.87). Overall mean CRP in the population was 0.4 mg/dL (standard deviation 0.78). In adjusted regression models with CRP as a continuous measure, individuals with high CRP had significantly lower MPV (b ¼ À0.04; standard error 0.01; 95% confidence interval À0.06 to À0.01; P ¼ 0.002). In adjusted regression models using CRP categories, participants with high CRP (>3 mg/dL) had significantly lower MPV compared with the low CRP group (b ¼ À0.20; standard error 0.09; 95% confidence interval À0.38 to À0.01; P ¼ 0.035). Our study revealed a significant inverse correlation between MPV and CRP in NHANES participants.

Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis

“…In addition, IBD patients suffer from anemia due to poor intestinal absorption or intestinal bleeding. 44 In this study, a significant increase in HGB, RBCs, and HCT was observed after the PCO treatment, suggesting the ameliorative effect of PCOs on anemia in the colitis mice (Fig. 1I–K).…”

Salivary and Serum Interleukin-10, C-Reactive Protein, Mean Platelet Volume, and CRP/MPV Ratio in the Diagnosis of Late-Onset Neonatal Sepsis in Full-Term Neonates

“…In clinical practice, MPV could be used as an indicator for the early diagnosis of neonatal sepsis [15,[20][21][22][23]. Several studies have examined the potential correlation between CRP and MPV values in patients with inflammatory states [24][25][26][27]. But only one study investigated the CRP/MPV ratio in children with pneumonia [28].…”

Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases

“…MPV was found to be negatively correlated with ESR and CRP in patients with rheumatoid arthritis and inflammatory bowel disease [26,27]. However, the largest study about the relation between MPV and CRP come from a population study of National Health and Nutrition Examination Survey (NHANES) data in 16,329 subjects revealing a significant negative correlation between MPV and CRP [28].…”