Relation Between Office Intraocular Pressure and 24-hour Intraocular Pressure in Patients With Primary Open-angle Glaucoma Treated With a Combination of Topical Antiglaucoma Eye Drops

Nakakura, Shunsuke; Nomura, Yuya; Ataka, Shinsuke; Shiraki, Kunihiko

doi:10.1097/ijg.0b013e31802ff85f

Cited by 53 publications

(44 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Barkana et al [24] highlighted that current standards do not identify nearly 70% of peak IOP and underestimate fluctuations by a mean of 3 mm Hg. Similar results were obtained in other studies showing IOP peaking outside office hours in 52-66% of cases [25,26,27,28]. In our study, we showed that the collection of a large number of measurements can clarify the characteristics of IOP in most cases, highlighting the correlation between these parameters.…”

Section: Discussionsupporting

confidence: 78%

Short- and Long-Term Phasing of Intraocular Pressure in Stable and Progressive Glaucoma

et al. 2013

View full text Add to dashboard Cite

Aims: To evaluate short- (ST) and long-term (LT) intraocular pressure (IOP) in patients with stable (SG) and progressive glaucoma (PG). Materials and Methods: Fifty-two patients with treated glaucoma received a baseline 24-hour IOP curve and, every 6 months for 2 years, office-hour curve plus visual field test. Based on field changes, they were divided into 24 SG and 28 PG. ST and LT IOP mean, peak and fluctuation (standard deviation of measurements) were calculated. Parameters determining progression were evaluated by logistic regression. Results: At ST, SG and PG, respectively, had mean IOP of 16.8 ± 2.2 and 15.3 ± 1.8 mm Hg; peak of 19.7 ± 3.3, 17.4 ± 2.3 mm Hg; fluctuation of 2.3 ± 1.2, and 1.6 ± 0.6 mm Hg. LT parameters did not change in SG, whereas a significant increase of mean (+1.0 ± 1.5 mm Hg, p = 0.05), peak (2.0 ± 2.4 mm Hg, p = 0.0002), and fluctuation (0.5 ± 1.1 mm Hg, p = 0.008) occurred in PG. Mean, peak, and fluctuation were correlated, except mean and fluctuation in the long term. Association with progression was shown for change in mean IOP between ST and LT, and ST peak. Conclusions: SG and PG may show different IOP parameters when intensively measured at baseline and follow-up. Mean IOP change between ST and LT periods and ST peak were the parameters associated with progression.

show abstract

Section: Discussionsupporting

confidence: 78%

Short- and Long-Term Phasing of Intraocular Pressure in Stable and Progressive Glaucoma

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Nakakura et al 87 also investigated the relation between office and 24-hour IOP characteristics in 71 treated eyes of 42 POAG patients. Office IOP was derived from three outpatient measurements (9 AM to 6 PM) during a six-month period with the same treatment.…”

Section: Circadian Iop Variations In Treated Eyesmentioning

confidence: 99%

24-hour Intraocular Pressure and Ocular Perfusion Pressure in Glaucoma

Quaranta

Katsanos

Russo

et al. 2013

Survey of Ophthalmology

140

147

View full text Add to dashboard Cite

Abstract. This review analyzes the currently available literature on circadian rhythms of intraocular pressure (IOP), blood pressure, and calculated ocular perfusion pressure (OPP) in patients with openangle glaucoma. Although adequately powered, prospective trials are not available. The existing evidence suggests that high 24-hour IOP and OPP fluctuations can have detrimental effects in eyes with glaucoma. The currently emerging continuous IOP monitoring technologies may soon offer important contributions to the study of IOP rhythms. Once telemetric technologies become validated and widely available for clinical use, they may provide an important tool towards a better understanding of longand short-term IOP fluctuations during a patient's daily routine. Important issues that need to be investigated further include the identification of appropriate surrogate measures of IOP and OPP fluctuation for patients unable to undergo 24-hour measurements, the determination of formulae that best describe the relationship between systemic blood pressure and IOP with OPP, and the exact clinical relevance of IOP and OPP fluctuation in individual patients. Despite the unanswered questions, a significant body of literature suggests that OPP assessment may be clinically relevant in a significant number of glaucoma patients. (Surv Ophthalmol 58:26--41, 2013. Ó 2013 Elsevier Inc. All rights reserved.) Key words. glaucoma circadian rhythm intraocular pressure blood pressure ocular perfusion pressure I. Physiological ConsiderationsThe principal physiological entities that affect intraocular pressure (IOP) and its characteristics are the aqueous humor (AH) dynamics in healthy and glaucomatous eyes.The production of AH involves two consecutive processes. First, a portion of the plasma that reaches the vascular plexus of the ciliary processes is filtered through the fenestrated capillaries into the interstitial space between the vessels and the ciliary epithelia. Next, a portion of the filtrate is actively secreted by the ciliary epithelial cells into the posterior chamber.In humans, these processes are affected by age, circadian rhythm, topical and systemic medications, and the presence of glaucoma. 63,64,70,109,121 The rate of AH formation decreases with age: by 15--35% between age 20 and 80 years. 15,30 The rate of AH production in humans is significantly lower at night, 99,119 attributed to decreased endogenous circulating catecholamine levels, which may partly explain the decreased nocturnal efficacy of topical 26

show abstract

“…We suspect that this disparity may be due to measurement of daytime IOP only and that maximum and minimum IOP may have changed outside of daytime hours in the earlier study. 7,8 is that the earlier investigators included both eyes in their study, which may have led to a TNR double-counting error. Additionally, 96% of their patients were Caucasians.…”

Section: Discussionmentioning

confidence: 99%

Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma

Nomura¹,

Nakakura²,

Moriwaki³

et al. 2010

OPTH

View full text Add to dashboard Cite

Purpose: The effect of travoprost 0.004% on 24-hour intraocular pressure (IOP) was examined in patients with normal tension glaucoma (NTG). Subjects and methods: This study included 17 patients with newly diagnosed unilateral NTG. IOP was measured at three-hour intervals over 24 hours by Goldman applanation tonometer in patients taking topical travoprost 0.004% and was compared retrospectively with 24-hour IOP data in untreated eyes. Results: IOP values were significantly reduced at individual time points after treatment (P , 0.01). Mean 24-hour IOP, maximum 24-hour IOP, minimum 24-hour IOP, and 24-hour IOP fluctuations at baseline (mean ± SD) were 12.9 ± 2.2 mmHg, 15.4 ± 2.7 mmHg, 10.5 ± 2.2 mmHg, and 4.9 ± 1.2 mmHg, respectively, and were significantly reduced to 10.3 ± 2.0 mmHg, 12.4 ± 2.5 mmHg, 8.5 ± 1.9 mmHg (all P , 0.001), and 3.9 ± 1.5 mmHg (P , 0.05), respectively, after treatment. The rate of IOP reduction greater than 20% was 58.8% (10 eyes) for maximum 24-hour IOP and 53.0% (nine eyes) for mean 24-hour IOP. Conclusion: Travoprost reduced IOP throughout the 24-hour study period, with over half of the eyes examined showing IOP reduction exceeding 20%.

show abstract

Relation Between Office Intraocular Pressure and 24-hour Intraocular Pressure in Patients With Primary Open-angle Glaucoma Treated With a Combination of Topical Antiglaucoma Eye Drops

Abstract: In POAG patients treated with 3 kinds of antiglaucoma eye drops, office IOP was similar to mean 24-hour IOP. However, it was difficult to estimate 24-hour IOP fluctuation and maximum 24-hour IOP on the basis of office IOP.

Cited by 53 publications

References 23 publications

Short- and Long-Term Phasing of Intraocular Pressure in Stable and Progressive Glaucoma

Short- and Long-Term Phasing of Intraocular Pressure in Stable and Progressive Glaucoma

24-hour Intraocular Pressure and Ocular Perfusion Pressure in Glaucoma

Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma

Contact Info

Product

Resources

About