Relation between serum IL-17 level and risk of osteoporotic fracture in premenopausal rheumatoid arthritis patients: Clinical, radiological and laboratory studies

Korayem, Hamdy Khamis; Rezk, Mohamed M; Hassan, Mohamed; El-Tawab, Sarah Sayed; Elsaid, Nesrin Ahmed

doi:10.1016/j.ejr.2015.06.006

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…However, no significant correlation could be detected between the serum level of IL-17 and HAQ-DI. In agreement with Korayem et al [28] and Yue et al (2010) [30], no correlation between serum level of IL-17 and HAQ was found. This finding may be due to the small sample size and also could be explained by the HAQ-DI is a subjective questionnaire differing from one patient to another regarding their dependency, socioeconomic class, or grade of disease activity.…”

Section: Discussionsupporting

confidence: 90%

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Is interleukin-17 implicated in early knee osteoarthritis pathogenesis as in rheumatoid arthritis?

Abdel-Naby

El-Tawab

Rizk

et al. 2022

Egypt Rheumatol Rehabil

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Background Interleukin-17 (IL-17) is a cytokine that promotes activation of multiple catabolic pathways resulting in cartilage and tissue damage. It has features making it increasingly attractive as a biological marker, especially in rheumatoid arthritis (RA) and osteoarthritis (OA). However, its expression is heterogeneous; not all patients’ exhibit high IL-17 levels, and its level along the disease course is still challenging to predict. Aim of the work The objectives of this study were to compare serum IL-17 levels in patients with early knee OA and in RA patients, to determine its correlation with disease activity in RA and to determine if it is correlated with functional scores in both RA and OA. Subjects and methods Twenty early knee OA patients (32.7 ± 3.7) years were included. Diagnosis of early OA was based on Luyten et al. 2012 early knee OA classification (early OA 2012). This study also included 25 RA patients aged 32.8 ± 5.1 years, and the diagnosis was according to 2010 ACR-EULAR classification criteria for RA. The current work also included a control group of 20 healthy volunteers aged 31.9 ± 3.2 years. The serum IL-17 level was assessed by using the ELISA technique. Results Serum IL-17 level was significantly high in early knee OA patients (5.2 pg/ml) and was significantly higher in RA patients (5.9 pg/ml) compared to the control group (4.9 pg/ml) (P < 0.001). Conclusions The increased serum IL-17 level in patients with early knee OA suggests its pathogenic role in the disease. Serum IL-17 positive correlation with the severity of knee OA-related pain proposes that it may be a potential marker to target for early treatment of knee OA-related pain.

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Section: Discussionsupporting

confidence: 90%

“…Also, the synovial fluid IL-17 level was found to be higher than its serum level, as mentioned by Rosu et al ( 2012) [14]. In agreement with other studies on Egyptian RA patients, IL-17 was significantly increased but did not correlate with clinical, laboratory, or radiographic scores [27,28].…”

Section: Discussionsupporting

confidence: 85%

Is interleukin-17 implicated in early knee osteoarthritis pathogenesis as in rheumatoid arthritis?

Abdel-Naby

El-Tawab

Rizk

et al. 2022

Egypt Rheumatol Rehabil

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“…T cells are the IL-17 source, while its receptor is expressed on fibroblasts, osteoblasts, chondrocytes, macrophages, dendritic, as well as on endothelial, and most parenchymal cells [14]. IL-17 is one of contributor of bone deterioration in long-established auto-immune inflammatory disorders associated with bone loss including psoriasis, rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus [6,9,15].…”

Section: Discussionmentioning

confidence: 99%

Serum interleukin-17 and estradiol levels in postmenopausal women in relation to osteoporosis

El-Mallah

Saab

Nassar

2021

Egypt Rheumatol Rehabil

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Background In post-menopausal women, estrogen deficiency leads to instability between bone formation and resorption which is regulated by osteoclastogenic cytokines leading to resorption. Interleukin-17 (IL-17) a proinflammatory cytokine has been found as an important regulator of osteoclast-genesis induced by estrogen deficiency in favor of bone loss in animal studies. The study aimed to evaluate levels of IL-17 and estrogen (E2) in relation to bone mineral density (BMD) and risk of fracture in postmenopausal women with and without osteoporosis. Results IL-17 levels were significantly higher and E2 levels were significantly lower in the osteoporotic group compared to the non-osteoporotic group (P value ≤ 0.01). There was a highly significant difference in DEXA score and FRAX index between two groups: with higher values of FRAX and lower values of DEXA score among osteoporotic group (P value ≤ 0.01). IL-17 was inversely correlated to estrogen level and highly significant negative correlation with DEXA as well as a highly significant positive one with FRAX index. IL-17 serum level was able to diagnose osteoporosis at a cutoff level of > 80 pg/mL with 100% sensitivity, 100% specificity, 100% positive predictive value (PPV), and 100% negative predictive value (NPV). Conclusions Serum IL-17 was significantly elevated in osteoporotic postmenopausal women when compared to healthy postmenopausal ones and was inversely correlated with estrogen level and DEXA.

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“…This result were incompatible with the results of [7] found the increment of IL-17A level associated highly with the age & period of menopause in postmenopausal women were they suffered from osteoporosis. There are relationship between IL-17A level in serum & osteoporosis [23]. Also incompatibility may belong to the method of IL-17A detection or to the type of kits, materials & instrument which used for the detection of IL-17A.…”

Section: Discussionmentioning

confidence: 99%

Detection of Estrogen and IL-17A Levels in Serum of Premenopausal and Postmenopausal Women in Kirkuk City Iraq

Pambuk¹

2017

SOJI

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Relation between serum IL-17 level and risk of osteoporotic fracture in premenopausal rheumatoid arthritis patients: Clinical, radiological and laboratory studies

Cited by 8 publications

References 29 publications

Is interleukin-17 implicated in early knee osteoarthritis pathogenesis as in rheumatoid arthritis?

Is interleukin-17 implicated in early knee osteoarthritis pathogenesis as in rheumatoid arthritis?

Serum interleukin-17 and estradiol levels in postmenopausal women in relation to osteoporosis

Detection of Estrogen and IL-17A Levels in Serum of Premenopausal and Postmenopausal Women in Kirkuk City Iraq

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