Relation Between Sources of Particulate Air Pollution and Biological Effect Parameters in Samples from Four European Cities: An Exploratory Study

Steerenberg, P. A.; Amelsvoort, L.G.P.M. van; Løvik, Martinus; Hetland, Ragna Bogen; Alberg, Torunn; Hałatek, Tadeusz; Bloemen, H.J.Th.; Rydzyński, K; Swaen, Gerard M. H.; Schwarze, Per E.; Dybing, Erik; Cassee, Flemming R.

doi:10.1080/08958370500515913

Cited by 72 publications

(38 citation statements)

References 44 publications

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“…Cu, Cr and Co in PM 2.5-1 and Co in PM 10-2.5 had statistically significant positive correlations with the particulate sample-induced inflammatory responses. This is also in line with our previous studies in six European cities Happo et al, 2008) and in a study of Steerenberg et al (2006). Those components are associated with non-exhaust emissions from traffic, e.g.…”

Section: Elementssupporting

confidence: 84%

Chemical and microbial components of urban air PM cause seasonal variation of toxicological activity

Jalava

Happo

Huttunen

et al. 2015

Environmental Toxicology and Pharmacology

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Section: Elementssupporting

confidence: 84%

Chemical and microbial components of urban air PM cause seasonal variation of toxicological activity

Jalava

Happo

Huttunen

et al. 2015

Environmental Toxicology and Pharmacology

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“…In the latter study, increased hepatic inflammation was noted, but the exposure concentration was a thousand fold higher than in the current study. Seasonal and geographic variability in ambient PM concentrations and components alter its effect on pulmonary (Nadadur and Kodavanti, 2002;Prophete et al, 2006) and cardiovascular disease (Steerenberg et al, 2006). Further studies are needed to determine the route and extent to which inhaled particulate matter reaches the liver.…”

Section: Discussionmentioning

confidence: 99%

Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease

Tan

Fiel

Sun

et al. 2009

Journal of Immunotoxicology

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Due to increased obesity, non-alcoholic fatty liver disease (NAFLD) is now the most prevalent liver disease in the United States. NAFLD is considered a component of metabolic syndrome, a cluster of disorders that also includes diabetes mellitus, dyslipidemia, arteriosclerosis, and hypertension. Exposure to ambient air particulate matter with aerodynamic diameters < 2.5 µm (PM 2.5 ) is a risk factor for arteriosclerosis as well as lung disease, but its effect on NAFLD is unknown. PM 2.5 induces pulmonary dysfunction via toll-like receptor activation on alveolar macrophages. Toll-like receptor activation of Kupffer cells, resident hepatic macrophages, and subsequent pro-inflammatory cytokine production have been shown to play a key role in NAFLD progression. We hypothesized that PM 2.5 exposure is a significant risk factor for progression of NAFLD. Thus, following exposure of male C57BL/6 mice fed high fat chow to concentrated air particulate matter (CAPs) or filtered air for 6 wk, progression of NAFLD was evaluated by standardized histological assessment of hepatic inflammation and fibrosis. In mice fed high fat chow, the hepatic inflammatory grade (3.00 ± 0.00 vs. 1.50 ± 0.71, p < 0.001) and fibrosis stage (1.00 ± 0.00 vs. 0.60 ± 0.52, p = 0.023) were both significantly higher in mice exposed to CAPs versus filtered air, respectively. Increased numbers of Kupffer cells contained PM in CAPsexposed mice (2.00 ± 0.94 vs. 0.20 ± 0.42, respectively, p < 0.001). PM exposure increased IL-6 secretion up to seven fold in a dose-dependent manner by isolated wild-type but not TLR4 −/− Kupffer cells (p < 0.050). Conclusion: Ambient PM 2.5 exposure may be a significant risk factor for NAFLD progression.

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“…In other words, the evidence is mainly derived from PM samples of which PM composition has been determined and used for source apportionment. For example, Steerenberg et al (2006) identified, in a small data set, that industrial combustion and/or incinerators were associated with respiratory allergy. Specific data on the toxicity of industry emitted PM other than combustion-derived PM has not been published since 2005.…”

Section: Toxicological and Clinical Studiesmentioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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Relation Between Sources of Particulate Air Pollution and Biological Effect Parameters in Samples from Four European Cities: An Exploratory Study

Cited by 72 publications

References 44 publications

Chemical and microbial components of urban air PM cause seasonal variation of toxicological activity

Chemical and microbial components of urban air PM cause seasonal variation of toxicological activity

Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

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