Relation of aging with oxidative protein damage parameters in the rat skeletal muscle

Çakatay, Ufuk; Telci, Ayşegül; Kayalı, Refik; Tekeli, Fatma; Akçay, Tülay; Sıvas, Ahmet

doi:10.1016/s0009-9120(02)00407-1

Cited by 80 publications

(49 citation statements)

References 29 publications

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“…Increased PC content has been introduced as a major cause of diabetic complications in humans with type 1 and type 2 diabetes (Brownlee, 2001). Additionally, similar results were reported in diabetic animals (Cakatay et al, 2003;Dursun et al, 2005). Furthermore, increased PC levels were found in diabetic rat lung (Eren et al, 2010).…”

Section: Discussionsupporting

confidence: 63%

“…Oxidative stress results in the LPO formation (referred as oxidative degradation of lipids), an increase in PC level and, consequently, tissue injury in humans with type 1 and type 2 diabetes (Brownlee, 2001). Similar results were reported in diabetic animals (Cakatay et al, 2003;Dursun et al, 2005;Xiong et al, 2012). Several studies reported the effect of chard in reducing hyperglycemia and its antioxidant property (Ozsoy-Sacan et al, 2004;Sacan & Yanardag, 2010;Yanardag et al, 2002).…”

Section: Discussionsupporting

confidence: 63%

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Chard (Beta vulgarisvar.cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

Öztay¹,

Saçan

Kayalar³

et al. 2015

Pharmaceutical Biology

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Context: Chard is used as an antidiabetic agent by the diabetic patients in Turkey. Objective: The effect of chard extract [Beta vulgaris L. var. cicla (Chenopodiaceae)] on the antioxidant system and the expression of surfactant-associated proteins (SP) in the lungs of hyperglycemic rats were examined. Materials and methods: Hyperglycemia was induced by a single dose of streptozotocin (60 mg/kg) provided intraperitoneally. Fourteen days after the rats were rendered hyperglycemic, the chard (2 g/kg/d), insulin (6 U/kg/d), and chard plus insulin (as mentioned above) were administered to rats for 45 d. On day 60, rats' lungs were removed. Oxidative stress parameters and SP expression were assayed. Results: The lungs of hyperglycemic rats were characterized by the induced lipid and protein oxidation, elevated myeloperoxidase and xanthine oxidase activities, decreased glutathione levels, and reduced tissue factor and antioxidant enzymes activities (catalase, superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase). Chard treatment alone and chard treatment combined with insulin were capable of achieving a regression of pulmonary oxidative stress, by inhibiting lipid and protein oxidation, and restoring the antioxidant system of hyperglycemic rats. SP-A expressions were significantly unchanged in all groups, whereas pro-SP-C and SP-D expressions were reduced in hyperglycemic rats. Pro-SP-C and SP-D levels were increased by chard and insulin administrations alone and combined in hyperglycemic rats. Discussion and conclusion: All treatments have a positive effect on the surfactant and antioxidant systems of the lungs of hyperglycemic rats. The best therapeutic effect was provided by treatment with chard extract alone in the compensation of hyperglycemic symptoms.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionsupporting

confidence: 63%

Chard (Beta vulgarisvar.cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

Öztay¹,

Saçan

Kayalar³

et al. 2015

Pharmaceutical Biology

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“…However as far as the authors knowledge there is no study concerning AOPPs in neurodegenerative diseases. Cakatay et al investigated the relation between aging and oxidative protein damage parameters and the AOPP levels in the skeletal muscle of the old rat group were significantly increased compared with those of the adult rats [6] . In this study AOPPs were measured and presented as a possible novel marker of oxidative stress in dementia.…”

Section: Resultsmentioning

confidence: 99%

“…In a study, AOPP levels of skeletal muscle in the old rat group were significantly increased compared with those of the adult rats [6] . Because of structural similarity of AOPPs to AGEs, they might exert similar biological activities, i.e.…”

Section: Am J Immunol 3 (2): 52-55 2007mentioning

confidence: 93%

“…Oxidative stress results from a distruption of the natural balance between pro-and -anti-oxidant system in favor of the former [5] . The free radical theory of aging states that the reactive oxygen species (ROS) cause oxidative damage over the lifetime of the subject [6] . Central nervous system that is containing postmitotic cells which are liable to accumulate oxidative damage over time, is particularly vulnerable to oxidative stress and uses a large amount of oxygen [7] .…”

Section: Introductionmentioning

confidence: 99%

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Advanced Oxidation Protein Products in Aged with Dementia

Demirbilek¹,

Kılıç²,

Kömürcü³

et al. 2007

American J. of Immunology

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Abstract:The role of increased oxidative stress in the development of oxidative protein damage in aging have been reported. There is an important role of oxidative stress on development of dementia. Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress. The aim of this study was to compare AOPP levels in healthy aged person and aged person with dementia. AOPP levels were in the control group 83.36 ± 35.51 µmol/L, and 178.78 ± 110.50 µmol/L in the group with dementia. This elevation in the group with dementia was statistically significant (p<0.05). AOPP might be a useful novel indicator of oxidative stress in dementia.

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Effect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat

Kayalı

Çakatay

Akçay

et al. 2005

Cell Biochem. Funct.

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176

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In the present study, we investigated whether DL-alpha-lipoic acid (LA) supplementation could have prooxidant or antioxidant effects on oxidative protein damage parameters such as protein carbonyl (PCO), nitrotyrosine (NT), advanced oxidation protein products (AOPP), and protein thiol (P-SH), as well as oxidative stress parameters such as total thiol (T-SH), non-protein thiol (Np-SH), and lipid hydroperoxide (LHP) in the brain and the skeletal muscle tissue of aged rats. PCO, and NT levels were increased, AOPP and P-SH levels were not changed in the brain tissue of aged rats given LA supplementation. On the other hand, TSH, Np-SH, and LHP levels were decreased in the brain tissue of aged rats given LA supplementation. The levels of the same parameters were not significantly different in the skeletal muscle tissue of aged rats given LA supplementation. The increased levels of protein oxidation markers such as PCO, and NT in the brain tissue of LA-supplemented aged rats compared with non-supplemented aged rats may suggest that oxidative protein damage is increased in LA-supplemented aged rats. We assume that an explanation for our findings regarding LA supplementation on protein oxidation markers in the brain tissue of aged rats may be due to the prooxidant effects of LA. Depending on post-mitotic tissue type and dosage of LA, the prooxidant effects of LA supplementation, should be considered in future studies.

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Relation of aging with oxidative protein damage parameters in the rat skeletal muscle

Cited by 80 publications

References 29 publications

Chard (Beta vulgarisvar.cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

Chard (Beta vulgarisvar.cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

Advanced Oxidation Protein Products in Aged with Dementia

Effect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat

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