Relation of Apolipoprotein(a) Size to Alzheimer’s Disease and Vascular Dementia

Emanuele, Enzo; Peros, Emmanouil; Tomaino, Carmine; Feudatari, Enrica; Bernardi, Livia; Binetti, Giuliano; Maletta, Raffaele; Micieli, Giuseppe; Bruni, Amalia C.; Geroldi, Diego

doi:10.1159/000079200

Cited by 21 publications

(8 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous study showed that serum ApoA concentration was highly correlated with the severity of AD [57]. A significant association of AD was found with Lp(a), which was shown to be related to dementia [58] and AD [59]. A significant association of AD with ALB was found in our study.…”

Section: Discussionsupporting

confidence: 77%

Elevation of Peripheral BDNF Promoter Methylation Links to the Risk of Alzheimer's Disease

Chang

Wang

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

Brain derived neurotrophic factor (BDNF) has been known to play an important role in various mental disorders or diseases such as Alzheimer's disease (AD). The aim of our study was to assess whether BDNF promoter methylation in peripheral blood was able to predict the risk of AD. A total of 44 AD patients and 62 age- and gender-matched controls were recruited in the current case-control study. Using the bisulphite pyrosequencing technology, we evaluated four CpG sites in the promoter of the BDNF. Our results showed that BDNF methylation was significantly higher in AD cases than in the controls (CpG1: p = 10.021; CpG2: p = 0.002; CpG3: p = 0.007; CpG4: p = 0.005; average methylation: p = 0.004). In addition, BDNF promoter methylation was shown to be significantly correlated with the levels of alkaline phosphatase (ALP), glucose, Lp(a), ApoE and ApoA in males (ALP: r = −0.308, p = 0.042; glucose: r = −0.383, p = 0.010; Lp(a): r = 0.333, p = 0.027; ApoE: r = −0.345, p = 0.032;), ApoA levels in females (r = 0.362, p = 0.033), and C Reactive Protein (CRP) levels in both genders (males: r = −0.373, p = 0.016; females: r = −0.399, p = 0.021). Our work suggested that peripheral BDNF promoter methylation might be a diagnostic marker of AD risk, although its underlying function remains to be elaborated in the future.

show abstract

Section: Discussionsupporting

confidence: 77%

Elevation of Peripheral BDNF Promoter Methylation Links to the Risk of Alzheimer's Disease

Chang

Wang

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…462 Lp(a) plasma concentration and fibrinolytic activity are reported to be dependent on the apo(a) isoform size. 462,463 A meta-analysis of 27 prospective studies with a mean follow-up period of 10 years found that patients with baseline Lp(a) levels in the top third of the concentration distribution have an Ϸ60% increased risk of coronary heart disease as compared with those with Lp(a) levels in the bottom third (RRϭ1.6; 95% CI 1.4 to 1.8; PϽ0.00001). 464 Considerable evidence suggests that high Lp(a) levels promote ischemic stroke, but findings have not been completely consistent (Table 4).…”

Section: Elevated Lipoprotein(a)mentioning

confidence: 99%

Primary Prevention of Ischemic Stroke

Goldstein¹,

Adams²,

Alberts

et al. 2006

Stroke

1,087

285

View full text Add to dashboard Cite

Background and Purpose-This guideline provides an overview of the evidence on various established and potential stroke risk factors and provides recommendations for the reduction of stroke risk. Methods-Writing group members were nominated by the committee chair on the basis of each writer's previous work in relevant topic areas and were approved by the American Heart Association Stroke Council's Scientific Statement Oversight Committee. The writers used systematic literature reviews (covering the time period since the last review published in 2001 up to January 2005), reference to previously published guidelines, personal files, and expert opinion to summarize existing evidence, indicate gaps in current knowledge, and when appropriate, formulate recommendations based on standard American Heart Association criteria. All members of the writing group had numerous opportunities to comment in writing on the recommendations and approved the final version of this document. The guideline underwent extensive peer review before consideration and approval by the AHA Science Advisory and Coordinating Committee. Results-Schemes for assessing a person's risk of a first stroke were evaluated. Risk factors or risk markers for a first stroke were classified according to their potential for modification (nonmodifiable, modifiable, or potentially modifiable) and strength of evidence (well documented or less well documented). Nonmodifiable risk factors include age, sex, low birth weight, race/ethnicity, and genetic factors. Well-documented and modifiable risk factors include hypertension, exposure to cigarette smoke, diabetes, atrial fibrillation and certain other cardiac conditions, dyslipidemia, carotid artery stenosis, sickle cell disease, postmenopausal hormone therapy, poor diet, physical inactivity, and obesity and body fat distribution. Less well-documented or potentially modifiable risk factors include the metabolic syndrome, alcohol abuse, drug abuse, oral contraceptive use, sleep-disordered breathing, migraine headache, hyperhomocysteinemia, elevated lipoprotein(a), elevated lipoprotein-associated phospholipase, hypercoagulability, inflammation, and infection. Data on the use of aspirin for primary stroke prevention are reviewed.

show abstract

“…Stroke subtypes significantly contributed to heterogeneity assessed by meta-regression; stroke due to large artery atherosclerosis and stroke due to undetermined etiology reported significantly higher ORs (QM ¼ 6.89; p ¼ 0.03; beta ¼ 0.008; se ¼ 0.003). Four studies [47,48,54,56] dichotomized Lp(a) levels at 30 mg/dl (clinical cut-off) or 14 mg/dl, respectively, three studies [27,49,58] compared highest vs. lowest tertile or quartile, respectively, and three studies [45,55,57] reported risk differences for continuous increase in Lp(a), see eTable 6 in the supplement. Four studies reported sex-specific ORs [27,47,48,56].…”

Section: Caseecontrol Studiesmentioning

confidence: 99%