Relation of atherosclerosis risk factors with the number of involved coronary arteries in angiography

Golmohammadi, Ali; Sadeghi, Mohammadreza; Bakhshayeshi, Mina; Namdar, Hossein; Separham, Ahmad

doi:10.17546/msd.23422

Cited by 4 publications

(7 citation statements)

References 22 publications

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“…Indeed, our research confirmed other observations which considered BMI as an independent predictor in coronary endothelial dysfunction in patients with coronary artery disease [ 30 , 31 ]. However, this finding is contrary to number of previous studies which have suggested that BMI was not an independent factor of coronary artery disease or severity on multivariate stepwise linear regression analysis anymore [ 32 , 33 ]. This inconsistency might be due to the fact that our cohort is biased towards sever cardiovascular cases as well as elderly patients.…”

Section: Discussioncontrasting

confidence: 99%

“…Our outcome showed no significant correlation between diabetes mellitus and number of involved vessels (according to the classification in one, two and three vessel), but there was a probable considerable difference if it was evaluated based on one vessel and more than one vessel [ 33 ]. Other studies have been established that diabetics are more prone to multivessel coronary disease [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

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Application of the Truncated Zero-Inflated Double Poisson for Determining of the Effecting Factors on the Number of Coronary Artery Stenosis

Orooji

Sahranavard

Shakeri

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. Risk factors of coronary heart disease have been discussed in the literature; however, conventional statistical models are not appropriate when the outcome of interest is number of vessels with obstructive coronary artery disease. In this paper, a novel statistical model is discussed to investigate the risk factors of number of vessels with obstructive coronary artery disease. Methods. This cross-sectional study was conducted on 633 elderly cardiovascular patients at Ghaem Hospital, Mashhad, Iran from September 2011 to May 2013. Clinical outcome is number of vessels with obstructive coronary artery disease (=0, 1, 2, 3), and predictor variables are baseline demographics and clinical features. A right-truncated zero-inflated double Poisson regression model is performed which can accommodate both underdispersion and excess zeros in the outcome. The goodness-of-fit of the proposed model is compared with conventional regression models. Results. Out of 633 cardiovascular patients, 327 were male (51.7%). Mean age was ~ 65 ± 7 years (for individuals with zero, one ,and two coronary artery stenosis) and ~ 66 ± 7 years (for individuals with three coronary artery stenosis). BMI ( 0.04 ± 0.01 , p = 0.011 ) and female gender ( 0.19 ± 0.09 , p = 0.032 ) were significant associated with the count part of the model, and only BMI ( − 0.47 ± 0.2 , p = 0.011 ) was significantly predictive of logit part of the model. The goodness-of-fit measurements indicate that the proposed model outperforms the conventional regression models. Conclusion. The proposal regression model shows a better fit compared to the standard regression analysis in modeling number of vessels with obstructive coronary artery disease. Hence, using truncated zero-inflated double Poisson regression model—as an alternative model—is advised to study the risk factors of number of involved vessels of coronary artery stenosis.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Application of the Truncated Zero-Inflated Double Poisson for Determining of the Effecting Factors on the Number of Coronary Artery Stenosis

Orooji

Sahranavard

Shakeri

et al. 2022

Computational and Mathematical Methods in Medicine

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“…The results showed that the likelihood of coronary vessel involvement was significantly higher in patients aged older than 45 years. Golmohammadi et al (2016) proposed that age was positively associated with the number of involved vessels detected by angiography (10). Cantarelli et al (2015) proposed that patients older than 40 years had doubled odds of developing coronary vessel involvement when compared to patients younger than 40 years of age, which complied with our results (13).…”

Section: Discussionsupporting

confidence: 89%

“…Since CAD is the first leading cause of death in Iran (10) and the extent of coronary vessel involvement has a significant role in treatment planning and prognosis of many important diseases (11), this study was carried out to investigate the risk factors associated with the extent of coronary vessel involvement across the spectrum of CAD in patients referring to the Cardiac Ward of Valiasr Hospital of Birjand.…”

Section: Objectivesmentioning

confidence: 99%

Risk Factors Associated With the Extent of Coronary Vessel Involvement Across the Spectrum of Coronary Artery Disease

et al. 2021

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Background: Cardiovascular Disease (CVD) is one of the most important causes of mortality and morbidity in developed and developing countries. Objectives: This study aimed to evaluate the risk factors associated with the extent of coronary vessel involvement across the spectrum of Coronary Artery Disease (CAD) in patients referring to the Cardiac Ward of Vali-Asr Hospital of Birjand, Iran. Methods: A cross-sectional study was conducted on 3,394 patients undergoing coronary angiography at the Cardiac Ward of Vali-Asr Hospital of Birjand, Iran, in 2011-2015. Subjects were assigned to four groups in terms of the extent of coronary vessel involvement: Normal CAD, non-significant CAD, CAD, and non-obstructive CAD. Adjusted odds ratios and 95% confident intervals were calculated by including all variables with P values < 0.05 into the multivariate model to control for confounding factors. Data were analyzed using SPSS version 22. Results: Among male and female patients, those aged 45-65 years needed angiography more than other groups. Multiple logistic regression analysis showed that diabetes, male gender, FBS, and history of hypertension significantly increased the likelihood of coronary vessel involvement (P ≤ 0.05). Conclusions: The findings of the present study imply that age, male gender, FBS, and history of hypertension are the independent risk factors for the extent of coronary vessel involvement in CAD and non-significant CAD groups. To reduce the rates and consequences of CAD, it is paramount to control cardiovascular risk factors, screen susceptible populations at risk, and improve coronary interventional services.

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“…In all articles, 6037 samples were included, with a minimum and maximum of 80 autopsy samples and 2390 patients, respectively ( Table 1 ). 19 , 20 , 22 , 23 , 29 – 35 …”

Section: Resultsmentioning

confidence: 99%

Effect of cigarette smoking on coronary arteries and pattern and severity of coronary artery disease: a review

et al. 2021

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Objective Smoking is a risk factor for coronary artery disease (CAD) and a known factor influencing the severity and pattern of CAD. We summarized evidence regarding the effect of smoking on the number of occluded coronary arteries and the severity and pattern of CAD. Methods We extracted data from observational studies reporting the pattern and severity of CAD in smokers. The quality of studies was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology checklist, and results are reported in the Garrard table. The review process followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Results We screened 11 studies including 6037 samples. Six studies reported no relationship between smoking and the number of damaged arteries. One study reported that smoking was related to occlusion in the left anterior descending artery, but there was no relationship between smoking and the location of occlusion in the arteries. Smoking was related to CAD severity in five studies. Conclusions Smoking was found to be related to CAD severity and location of the damaged artery in the heart. However, there was no significant association of smoking with the number of damaged arteries and location of arterial occlusion.

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Relation of atherosclerosis risk factors with the number of involved coronary arteries in angiography

Cited by 4 publications

References 22 publications

Application of the Truncated Zero-Inflated Double Poisson for Determining of the Effecting Factors on the Number of Coronary Artery Stenosis

Application of the Truncated Zero-Inflated Double Poisson for Determining of the Effecting Factors on the Number of Coronary Artery Stenosis

Risk Factors Associated With the Extent of Coronary Vessel Involvement Across the Spectrum of Coronary Artery Disease

Effect of cigarette smoking on coronary arteries and pattern and severity of coronary artery disease: a review

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