Relation of C-Reactive Protein to Abdominal Adiposity

Brooks, Gabriel; Blaha, Michael J.; Blumenthal, Roger S.

doi:10.1016/j.amjcard.2010.02.017

Cited by 224 publications

(196 citation statements)

References 37 publications

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“…Some studies suggested associations between measures of overall 2,3 and abdominal 28,29 obesity and a series of inflammatory and metabolic markers. However, to the best of our knowledge, there is currently no agreement about which anthropometric measures predict best adverse levels of inflammatory markers, and how they differ by sex.…”

Section: Discussionmentioning

confidence: 99%

Ability of Measures of Adiposity in Identifying Adverse Levels of Inflammatory and Metabolic Markers in Adolescents

et al. 2016

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Background: Overweight and obesity have been associated with a pro-inflammatory state. We aimed to assess the ability of different measures of overall and abdominal adiposity for identifying adverse levels of inflammatory and metabolic markers in adolescents. Methods: This is a cross-sectional analysis with 529 Portuguese adolescents (267 girls), mean age 14.3 ± 1.7 years. Weight, height, sitting height, waist circumference (WC), and body fat percentage (BF%) were measured; and BMI, waist-to-height ratio (WHtR), and waist-to-sitting-height ratio (WsHtR) were calculated. We measured C-reactive protein (CRP), fibrinogen, erythrocyte sedimentation rate (ESR), complements C3 and C4, leptin, and adiponectin levels. Receiver operating characteristic (ROC) curves were used to estimate the ability of the adiposity measures to discriminate between low/high values of biomarkers. Results: The highest areas under the ROC curves were presented by BF% for fibrinogen and complement C3 in both sexes and for ESR, complement C4, and adiponectin only in girls; by BMI for CRP in girls and for leptin in both sexes; by WHtR for leptin in both sexes and for CRP, fibrinogen, and adiponectin only in girls; by waist circumference for CRP, fibrinogen, and complement C3 only in boys and for complement C4 in girls; and by WsHtR for complement C3 in girls; p < 0.05 for all. Conclusions: The measures that more often presented discriminatory power were, for overall adiposity, BF% in both sexes, and for abdominal adiposity, WHtR in girls and WC in boys. However, small differences in discriminatory capabilities don't allow us to clearly defend the adoption of a single measure above all others.

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Section: Discussionmentioning

confidence: 99%

Ability of Measures of Adiposity in Identifying Adverse Levels of Inflammatory and Metabolic Markers in Adolescents

et al. 2016

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“…It has been shown that increased neutrophil count is related to areas of ischemic injury (6)(7)(8). Furthermore, there are studies showing that there is a chronic low grade inflammation in DM (9), hypertension (10), metabolic syndrome (11), and obesity (12).…”

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confidence: 99%

Neutrophil-to-Lymphocyte Ratio as a Marker in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy

Polat¹,

Yavaş²,

İnan³

et al. 2015

Balkan Med J

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Background: Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in patients over the age of 50 and is the second most common cause of permanent optic nerverelated visual loss in adults after glaucoma. Although the precise cause of NAION remains elusive, the etiology of NAION is believed to be multifactorial. Aims: To evaluate the utility of neutrophil-to-lymphocyte ratio (NLR) as a simple and readily available prognostic factor for clinical disease activity in patients with NAION. Study Design: Case-control study. Methods: Forty-five patients with the diagnosis of NAION and 50 age-and sex-matched controls with/ without any systemic or ocular diseases except cataract were retrospectively enrolled in the study. Demographic characteristics and laboratory findings including complete blood count of all patients and control subjects were obtained from the electronic medical record.The neutrophil and lymphocyte counts were recorded and the NLR was calculated. Results: White blood cell, neutrophil, NLR and platelet values of the NAION patients were significantly higher than those of the controls (p<0.001, p<0.001, p=0.004, p=0.037, respectively). Initial NLR values were negatively correlated with initial and the third month best corrected visual acuity levels in the study group. The optimum NLR cut-off point for NAION was 1.94. Conclusion: NLR could be considered as a new inflammatory marker for assessment of the severity of inflammation in NAION patients with its quick, cheap, easily measurable property with routine complete blood count analysis.

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“…Obesity occurs when BMI is over 30 kg/m2 (39). A positive association was detected between the CRP levels and lipid amounts within the whole body (40,41). In case of obesity the secretion of high amounts of IL-6 from the adipose tissue elevates CRP levels as well as the risk of CVDs (42,43).…”

Section: Factors Increasing Crp Levelsmentioning

confidence: 99%

An Association Between C-reactive Protein and Cardiovascular Diseases

Doḡru¹,

Hamamcıoğlu²,

Yeşiltaş³

2017

MJWBS

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C reaktif protein akut faz proteini olup, enflamasyon olayları sırasında karaciğerden salınımı uyarılır. Enfeksiyonların teşhisinde ve hastalığın seyrinin takibinde uzun zamandır kullanılmaktadır. Kardiyovasküler sistem ve enflamasyon arasındaki ilişkinin gösterilmesi enflamatuvar belirteçlerin önemini artırmıştır. CRP düzeyinin bakteriyel, viral enfeksiyonlar ve romatizmal hastalıkların yanısıra ateroskleroz gibi kardiyovasküler olaylarda da artığı görülmüştür. CRP düzeylerinin saptanmasıyla hastalığın takibi sağlanabilir ve sağlıklı bireyler için kardiyovasküler hastalık riski önceden saptanabilir. Yapılan pek çok çalışmada, aterosklerozlu, myokard enfarktüslü, aritmili, diabetes mellituslu ve hipertansiyonlu hastalarda CRP düzeylerinde anlamlı artış bulunmuştur. Kardiyovasküler hastalıklarla CRP arasındaki ilişkinin altında yatan mekanizmaların anlaşılması için daha fazla çalışmaya ihtiyaç vardır.

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Relation of C-Reactive Protein to Abdominal Adiposity

Cited by 224 publications

References 37 publications

Ability of Measures of Adiposity in Identifying Adverse Levels of Inflammatory and Metabolic Markers in Adolescents

Ability of Measures of Adiposity in Identifying Adverse Levels of Inflammatory and Metabolic Markers in Adolescents

Neutrophil-to-Lymphocyte Ratio as a Marker in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy

An Association Between C-reactive Protein and Cardiovascular Diseases

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